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The effect of different hyperglucagonemic states on monooxygenase activities and isozymic pattern of cytochrome P-450 in mouse

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Bioscience Reports

Abstract

The continuous infusion of a low dose of glucagon (35 μg/kg/d, for 5 d) constitutes, in view of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities , a reliable experimental model of hyperglucagonemia. By conjunction of monooxygenase assays and immunoquantitation of specific isozymes of cytochrome P-450, the actual inducing ability of glucagon has been shown and it might explain some of the modifications of the drug metabolizing system in diabetic mice. The isozymic pattern of cytochrome P-430 of liver microsomes from diabetic mice appears very different from that produced by classical inducers.

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Authors and Affiliations

  1. INSERM U 75, CHU Necker Enfants Malades, 156 Rue de Vaugirard, 75015, Paris Cedex 15, France

    E. Rouer, P. Beaune, C. Augereau & J. P. Leroux

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  1. E. Rouer
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  2. P. Beaune
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  3. C. Augereau
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  4. J. P. Leroux
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Rouer, E., Beaune, P., Augereau, C. et al. The effect of different hyperglucagonemic states on monooxygenase activities and isozymic pattern of cytochrome P-450 in mouse. Biosci Rep 5, 335–341 (1985). https://doi.org/10.1007/BF01116906

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  • DOI: https://doi.org/10.1007/BF01116906

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