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Loop diuretics may fail to inhibit (Na+, K+, Cl−) ‘cotransport’ in human red cells

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Bioscience Reports

Abstract

The inhibition of passive K+ influx into human red blood ceils (RBC) by loop diuretics was found to be dependent on the external Na+ concentration, In the absence of external Na+, there was minimal inhibition but the influx remained dependent on CI- ions. Thus, raising the external Na+ concentration increased the affinity of the putative (Na+, K+, Cl− cotransport system in human RBC for loop diuretics.

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References

  1. Wiley JS & Cooper RA (1974) J. Clin. Invest.53, 745–755.

    Google Scholar 

  2. Chipperfield AR (1980) Nature286, 281–282.

    Google Scholar 

  3. Dunham PB, Stewart GW & Ellory JC (1980) Proc. Natl. Acad. Sci. U.S.A.77, 1711–1715.

    Google Scholar 

  4. Chipperfield AR (1981) J. Physiol., Lond.312, 435–444.

    Google Scholar 

  5. Kregenow FM (1981) A. Rev. Physiol.43, 493–505.

    Google Scholar 

  6. Ellory JC, Dunham PB, Logue PJ & Stewart GW (1982) Phil. Trans. R. Soc. Series B. Lond.299, 483–495.

    Google Scholar 

  7. Pallfrey HC & Rao MC (1983) J. Exp. Biol.106, 43–54.

    Google Scholar 

  8. Saier MM Jr & Boyden DA (1984) Mol. Cell. Biochem.59, 11–32.

    Google Scholar 

  9. Warnock DG, Greger R, Dunham PB, Benjamin MA, Frizzell RA, Field M, Spring KR, Ives HE, Aronson PS & Seifter J (1984) Fed. Proc.43, 2473–2487.

    Google Scholar 

  10. Reuss L, Lewis SA, Wills NK, Helman SI, Cox TC, Boron WF, Siebens AW, Guggino WB, Giebisch G & Schultz SG (1984) Fed. Proc.43, 2488–2502.

    Google Scholar 

  11. Wiater LA & Dunham PB (1983) Am. J. Physiol.245, C348-C356.

    Google Scholar 

  12. Ellory JC & Stewart GW (1982) Brit. J. Pharmacol.75, 183–188.

    Google Scholar 

  13. Pallfrey HC, Feit PW & Greengard P (1980) Am. J. Physiol.238, C139-C148.

    Google Scholar 

  14. Haas M & McManus TJ (1982) Biophys. J.37, 214a.

    Google Scholar 

  15. Chipperfield AR (1984) J. Physiol., Lond.353, 133P.

  16. Aiton JF, Chipperfield AR, Lamb JF, Simmons NL & Ogden P (1981) Biochim. Biophys. Acta646, 389–398.

    Google Scholar 

  17. Geck P, Heinz E & Pfeiffer B (1981) Scand. Audiol. Supp.14, 25–37.

    Google Scholar 

  18. Haas M, Schmidt WF III & McManus TJ (1982) J. Gen. Physiol.80, 125–247.

    Google Scholar 

  19. McRoberts JA, Erlinger S, Rindler MJ & Saier MM Jr (1982) J. Biol. Chem.257, 125–147.

    Google Scholar 

  20. Musch M, Orellana S, Kimberg LS, Field M, Halm DR, Krasny EJ & Frizzell RA (1982) Nature300, 351–353.

    Google Scholar 

  21. Russell JM (1983) J. Gen. Physiol.81, 909–925.

    Google Scholar 

  22. Ellory JC & Hall AC (1984) J. Physiol., Lond.357, 63P.

  23. Fry DJ (1984) J. Physiol., Lond.346, 91.

    Google Scholar 

  24. Hall AC, Ellory JC & Klein RA (1982) J. Membrane Biol.68, 47–56.

    Google Scholar 

  25. Bin Talib HK, Chipperfield AR & Semple PF (1984) J. Hypertension2, 405–409.

    Google Scholar 

  26. Blackstock EJ, Ellory JC & Stewart GW (1985) J. Physiol., Lond.358, 90P.

    Google Scholar 

  27. Blackstock EJ & Stewart GW (1985) J. Physiol., Lond. 18P, (in the press)

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Authors and Affiliations

  1. Department of Physiology, The University, DD1 4HN, Dundee, UK

    A. R. Chipperfield

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  1. A. R. Chipperfield
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Chipperfield, A.R. Loop diuretics may fail to inhibit (Na+, K+, Cl−) ‘cotransport’ in human red cells. Biosci Rep 5, 299–302 (1985). https://doi.org/10.1007/BF01116900

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  • DOI: https://doi.org/10.1007/BF01116900

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