Skip to main content
Log in

In vitro andin vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain

  • Short Papers
  • Published:
Bioscience Reports

Abstract

The effects of some organophosphate pesticides, e.g. lebaycid, metacid and metasystox on the monoamine oxidase (MAO) activity in rat brain mitochondria have been studied. These pesticides cause significant inhibition of MAO activityin vitro but have negligible effects on its activityin vivo.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Roger, J. C., Chambers, H. and Casida, J. E. (1964).Science 144:539–540.

    PubMed  Google Scholar 

  2. Eto, M. (1974). Organophosphorous pesticides in organic and biological chemistry, p. 123. CRC Press, Cleveland.

    Google Scholar 

  3. Gupta, M., Bagchi, G. K., Dutta Gupta, S., Sasmal, D., Chatterjee, T. and Dey, S. N. (1984).Toxicology 30:171–175.

    PubMed  Google Scholar 

  4. Main, A. R. and Iverson, F. (1966).Biochem. J. 100:525–531.

    PubMed  Google Scholar 

  5. Evaluation of some Pesticide Residues in Food; Monocrotophos. WHO Pesticide Residue Series (1975), p. 313.

  6. Matsumara, F. (1976).Toxicology of Insecticides. Plenum Press, New York and London, pp. 35, 47, 84.

    Google Scholar 

  7. Brown, A. W. A. (1978).Ecology of Pesticides. Wiley A. Interscience Publication, Wiley, J. and Sons, New York, p. 5.

    Google Scholar 

  8. Gupta, M. and Bagchi, G. K. (1982).Ind. J. Hosp. Pharm. July–August, 136–141.

  9. Ali, S. F., Chandra, O. and Hasan, M. (1980).Psychopharmacology 68:37–42.

    PubMed  Google Scholar 

  10. Purshottam, T. and Srivastava, R. K. (1984).Archives of Environmental Health 39:425–449.

    PubMed  Google Scholar 

  11. Brody, T. M. and Bain, J. A. (1952).J. Biol. Chem. 195:685–695.

    Google Scholar 

  12. Lowry, O. H., Rosebrough, N. J., Farr, L. and Randall, R. J. (1951).J. Biol. Chem. 193:265–275.

    PubMed  Google Scholar 

  13. Green, A. L. and Haughton, T. M. (1961).Biochem. J. 78:172–175.

    PubMed  Google Scholar 

  14. Guha, S. R. (1966).Biochem. Pharmacol. 15:161–168.

    PubMed  Google Scholar 

  15. Borsini, F., Bendotii, C., Velkov, V., Rech, R. and Samamin, R. (1981).J. Phar. Pharmacol. 33(1):33–35.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nag, M., Nandi, N. In vitro andin vivo effect of organophosphate pesticides on monoamine oxidase activity in rat brain. Biosci Rep 7, 801–803 (1987). https://doi.org/10.1007/BF01116753

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01116753

Key Words

Navigation