References
Doll, R. and Peto, R. (1981). The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today.J. Natl. Cancer Inst. 66:1193–1308.
Varmus, H. (1981). The molecular genetics of cellular oncogenes.Ann. Rev. Genetics 18:553–612.
Marshall, C. J. (1985). Human oncogenes. In:RNA Tumor Viruses. Molecular Biology of Tumor Viruses, 2nd edn. (R. A. Weiss, N. M. Teich, H. E. Varmus and J. Cofin, Eds.), Cold Spring Harbor Lab., New York. Vol. 22, pp. 486–558.
Doerfler, W. (1983). DNA methylation and gene activity.Ann. Rev. Biochem. 52:93–124.
Nyce, J., Weinhouse, S. and Magee, P. N. (1983). 5-Methylcytosine depletion during tumour development: An extension of the miscoding concept.Br. J. Cancer 48:463–475.
Boveri, T. (1929).On the Problem of the Origin of Malignant Tumors. Baltimore: Williams and Wilkins (translated by M. O. Boveri).
Foulds, L. (1954). The experimental study of tumor progression. A review.Cancer Res. 14:327–339.
Huebner, R. M. and Todaro, G. J. (1969). Oncogenes of RNA tumor viruses as determinants of cancer.Proc. Natl. Acad. Sci. USA 64:1087–1094.
Temin, H. M. (1971). The protovirus hypothesis: speculations on the significance of RNA-directed DNA synthesis for normal development and for carcinogenesis.J. Natl. Cancer Inst. 46:3–7.
Comings, D. E. (1973). A general theory of carcinogenesis.Proc. Natl. Acad. Sci. USA 70:2324–2328.
Cairns, J. (1981). The origins of human cancers.Nature 289:353–357.
Weinstein, I. B., Gattoni-Celli, S., Kirschmeier, P., Lambert, M., Hsiao, W., Backer, J. and Jeffrey, A. (1984). Multistage carcinogenesis involves multiple genes and multiple mechanisms. In:Cancer Cells (A. J. Levine, G. F. Vande Woude, W. C. Topp and J. D. Watson, Eds.), Cold Spring Harbor Laboratory, New York, USA. Vol. 1, pp. 229–237.
Spandidos, D. A. and Wilkie, N. M. (1984). Expression of exogenous DNA in mammalian cells. In:In Vitro Transcription and Translation—A Practical Approach (B. D. Hames and S. J. Higgins, Eds.), IRL Press, Oxford, UK, pp. 1–48.
Wyke, J. A. and Weiss, R. A. (1984). The contribution of tumor viruses to human and experimental oncology.Cancer Surveys 3:1–24.
Knudson, A. G. (1985). Hereditary cancer oncogenes, and antioncogenes.Cancer Res. 45:1437–1443.
Spandidos, D. A. (1985). Mechanism of carcinogenesis: the role oncogenes, transcriptional enhancers and growth factors.Anticancer Res. 5:485–498.
Spandidos, D. A. and Siminovitch, L. (1985). Transfer of anchorage independence by isolated metaphase chromosomes in hamster cells.Cell 12:675–682.
Spandidos, D. A. and Siminovitch, L. (1978). Transfer of the marker for the morphologically transformed phenotype by isolated metaphase chromosomes in hamster cells.Nature,271:259–261.
Shih, C., Shilo, B.-Z., Goldfarb, M. P., Dannenberg, A. and Weinberg, R. A. (1971). Passage of phenotypes of chemically transformed cells via transfection of DNA and chromatin.Proc. Natl. Acad. Sci. USA 76:5714–5718.
Sandos, E. Sukumar, S., Martin-Zanca, D., Zarbl, H. and Barbacid, M. (1985). Transformingras genes. In:Viruses and Cancer (P. W. J. Rigby and N. M. Wilkie, Eds.), Cambridge University Press, pp. 291–313.
Ponder, B. A. J. (1980). Genetics and cancer.Biochem. Biophys. Acta 605:369–410.
Lehman, A. R. (1982). Xeroderma pigmentosum, Cockayne syndrome and ataxia-telangiectasia: Disorders relating DNA repair to carcinogenesis.Cancer Surveys 1:93–118.
Meuth, M., L'Heureux-Huard, N. and Trudel, M. (1979). Characterization of a mutator gene in Chinese hamster ovary cells.Proc. Natl. Acad. Sci. USA 76:6505–6509.
Thorgeirsson, S. S. and Nebert, D. W. (1977). The Ah locus and the metabolism of chemical carcinogens and other foreign compounds.Adv. Cancer Res. 25:149–193.
Sodroski, J., Rosen, C., Goh, W. C. and Haseltine, W. (1985). A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.Science 228:1430–1434.
Miller, R. W. (1970). Neoplasia and Down's syndrome.Ann. N. Y. Acad. Sci. 171:637–644.
Benedict, W. F., Murphree, A. L., Banerjee, A., Spina, C. A., Sparkes, M. C. and Sparkes, R. S. (1983). Patient with 13 chromosome deletion: Evidence that the retinoblastoma gene is a recessive cancer gene.Science 219:973–975.
Cavenee, W. K., Doyja, T. P., Phillips, R. A., Benedict, W. F., Godbout, R., Gallie, B. L., Murphee, A. L., Strong, L. C. and White, R. L. (1983). Expression of recessive alleles by chromosomal mechanisms in retinoblastoma.Nature 305:779–784.
Murphee, A. L. and Benedict, W. F. (1984). Retinoblastoma: Clues to human oncogenes.Science 223:1028–1033.
Koufos, A., Hansen, M. F., Lampkin, B. C., Workman M. L., Copeland, N. G., Jenkins, N. A. and Cavanee, W. K. (1984). Loss of alleles at loci on human chromosome 11 during genesis of Wilm's tumour.Nature 309:170–172.
Cowell, J. K. (1984). Tracking the cancer genes in paediatric predisposition syndromes: opportunity for prenatal diagnosis.Cancer Surveys 3:573–601.
Kovelovich, L. (1982). Adenomatosis of the colon and rectum: relevance to inheritance and susceptibility mechanisms in human cancer.Cancer Surveys 1:71–91.
Wang, J. L. and Hsu, Y.-M. (1986). Negative regulators of cell growth.Trends in Biochem. Sci. 11: 24–26.
Land, H., Parada, L. F. and Weinburg, R. A. (1983). Tumorigenic conversion of primary embryo fibroblasts requires at least two co-operating oncogenes.Nature 304:596–602.
Scherer, E. (1984). Neoplastic progression in experimental hepatocarcinogenesis.Biochem. Biophys. Acta 738:219–236.
Spandidos, D. A. and Siminovitch, L. (1978). The relationship between transformation and somatic mutation in human and Chinese hamster cells.Cell 13:651–662.
Farber, E. (1984). Cellular biochemistry of the stepwise development of cancer with chemicals.Cancer Res. 44:5463–5474.
Armitage, P. and Doll, R. (1957). A two stage theory of carcinogenesis in relation to the age distribution of human cancer.Br. J. Cancer 11:161–169.
Ames, B. N. (1979). Identifying environmental chemicals causing mutations and cancer.Science 204:587–593.
Bouck, N. and I Mayorca, G. (1976). Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens.Nature 264:722–727.
Yunis, J. J. (1983). The chromosomal basis of human neoplasia.Science 221:227–236.
Knudson, A. G. (1971). Mutation and cancer: statistical study of retinoblastoma.Proc. Natl. Acad. Sci. USA 68:820–823.
Setlow, R. B. (1985). Repair deficient human disorders and cancer.Nature 271:713–717.
McKusick, V. A. (1975).Mendelian Inheritance in Man.4th edn. Baltimore: Johns Hopkins University Press.
Mulvihill, J. J. (1977). Genetic repertory of human neoplasia. In:Genetics of Human Cancer. (J. J. Mulvihill, R. V. Miller and J. J. F. Fraumoni Eds.), Raven Press, New York, pp. 241–306.
Anderson, D. E. (1978). An inherited form of large bowel cancer. Muir's syndrome.Cancer 45:1103–1107.
Graham, F. L. and Van der Eb, A. J. (1983). A new technique for the assay of infectivity of human adenovirus 5 DNA.Virology 52:456–461.
Sukumar, S., Notario, V., Martin-Zanca, D. and Barbacid, M. (1983). Induction of mamary carcinomas in rats by nitroso-methyl-urea involves the malignant activation of the Ha-ras-1 locus by single point mutations.Nature 306:658–661.
Balmain, A., Ramsden, M., Bowden, G. T. and Smith, J. (1984). Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas.Nature 307:658–660.
Guerrero, I., Corzada, P., Mayer, A. and Pellicer, A. (1984). Molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.Proc. Natl. Acad. Sci. USA 81:202–205.
Spandidos, D. A. and Kerr, I. B. (1984). Elevated expression of the humanras oncogene family in premalignant and malignant tumours of the colorectum.Br. J. Cancer 49:681–688.
Slamon, D. J., Dekernion, J. B., Verma, I. M. and Cline, M. J. (1984). Expression of cellular oncogenes in human malignancies.Science 224:256–262.
Spandidos, D. A., Lamothe, A. and Field, J. N. (1985). Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumours.Anticancer Res. 5:221–224.
Yokota, J., Tsunetsugu-Yokota, Y., Battifora, H., Le Fevre, C. and Cline, M. J. (1986). Alterations ofmyc, myb, andras Ha proto-oncogenes in cancers are frequent and show clinical correlation.Science 231:261–265.
Heppner, G. H. (1984). Tumor heterogeneity.Cancer Res. 44:2259–2262.
Westerveld, A., Hueijmakers, J. H. J., Van Duin, M., De Wit, J., Odijk, J., Pastink, A., Wood, R. D. and Bootsma, D. (1984). Molecular cloning of a human DNA repair gene.Nature 310:425–429.
Spandidos, D. A. and Wilkie, N. M. (1984). Malignant transformation of early passage rodent cells by a single mutated human oncogene.Nature 310:469–475.
Williams, A. R. W., Piris, J., Spandidos, D. A. and Wyllie, A. H. (1985). Immunohistochemical detection of theras oncogene p21 product in an experimental tumour and in human colorectal neoplasms.Br. J. Cancer 52:687–693.
Pragnell, I. B., Spandidos, D. A. and Wilkie, N. M. (1985). Consequences of altered oncogene expression in rodent cells.Proc. Roy. Soc. London UK B226:107–119.
Chang, E. H., Furth, M. E., Scolnick, E. M. and Lowy, D. R. (1982). Tumorigenic transformation of mammalian cells induced by a normal gene homologous to the oncogene of Harvey murine sarcoma virus.Nature 297:479–483.
Vousden, K. M. and Marshall, C. J. (1984). Three different activatedras genes in mouse tumours: Evidence for oncogene activation during progression of a mouse lymphoma.EMBO J. 3: 913–917.
Albino, A. P., Lestange, R., Oliff, A. I., Furth, M. E. and Old, L. J. (1983). Transformingras genes from human melanona: A manifestation of tumor heterogeneity?Nature 308:69–72.
Thorgeirsson, U. P., Turpeenniemi-Hujanen T., Williams, J. E., Westin, E. H., Heilman, C. A., Talmadge, J. E. and Liotta, L. A. (1985). NIH/3T3 cells transfected with human tumor DNA containing activatedras oncogenes express the metastatic phenotype in nude mice.Mol. Cell. Biol. 5:259–262.
Mougnieau, E., Lemieux, L., Rassoulzadegan, M. and Couzin, F. (1984). Biological activities of v-myc and rearranged c-myc oncogenes in rat fibroblast cells in culture.Proc. Natl. Acad. Sci. USA 81:5758–5762.
Keath, E. J., Caimi, P. G. and Cole, M. D. (1984). Fibroblast cell lines expressing activated c-myc oncogenes are tumorigenic in nude mice and syngeneric animals.Cell 39:339–348.
Little, C. D., Lau, M. M., Carney, D. N., Gazdar, A. F. and Minna, J. D. (1983). Amplification and expression of the c-myc oncogene in human lung cancer lines.Nature 306:194–196.
Besmer, P. (1984). Acute transforming feline retroviruses.Curr. Topics Microb. Imm. 107:1–28.
Neil, J. C., Hughes, D., McFarlane, R., Wilkie, N. M., Onions, D. E., Lees, G. and Jarrett, O. (1984). Transduction and rearrangement of the myc gene by feline leukemia virus in naturally occurring T-cell leukemias.Nature 308:814–820.
Neel, B. G., Hayward, W. S., Robinson, H. L., Fang, J. and Astrin, S. (1981). ALV induced tumours have common proviral integration sites and synthesise discrete new mRNA; oncogenes by promoter insertion.Cell 23:323–334.
Klein, G. (1981). The role of gene dosage and genetic transpositions in carcinogenesis.Nature 294:313–318.
Kirsch, I. R., Morton, C. C., Nakahara, K. and Leder, P. (1982). Human immunoglobulin heavy chain genes map to a region of translocations in malignant B lymphocytes.Science 216:301–303.
Battey, J., Moulding, G., Taub, R., Murphy, W., Stewart, T., Patter, G., Lenoir, G. and Leder, P. (1983). The human c-myc oncogene. Structural consequences of translocation into the Ig-H locus in Burkitt lymphoma.Cell 34:779–787.
Groffen, J., Stephenson, J. R., Heisterkamp, N., De Klein, A., Bartram, C. R. and Grosveld, G. (1984). Philadelphia chromosomal breakpoints are clustered within a limited region, ber, on chromosome 22.Cell 36:93–99.
Hayday, A., Gillies, S. D., Saito, H., Wood, C., Wiman, K., Hayward, W. S. and Tonegawa, S. (1984). Activation of a translocated human c-myc gene by an enhancer in the immunoglobulin heavy-chain locus.Nature 307:334–340.
Bernard, O., Cory, S., Gerondakis, S., Webb, E. and Adams, J. (1983). Sequence of the murine and human cellular myc oncogenes and two modes of myc transcription resulting from a chromosome translocation in B lymphoid tumours.EMBO J. 2:2375–2383.
Erikson, J., Ar-Rushdi, A., Orwinga, J. L., Nowell, P. C. and Croce, C. M. (1983). Transcriptional activation of the translocated c-myc oncogene in Burkitt lymphoma.Proc. Natl. Acad. Sci. USA 80:820–824.
Davis, M., Malcolm, S. and Rabbitts, T. H. (1984). Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells.Nature 308:286–288.
Rabbitts, P. H., Forster, A., Stinson, M. A. and Rabbitts, T. H. (1985). Translocation of exon 1 from the c-myc gene results in prolonged c-myc mRNA stability.EMBO J. 4:3727–3733.
Eick, D., Piechazyk, M., Henglein, B., Blanchard, J. M., Traub, B., Kofler, E., Wiest, S., Lenoir, G. M. and Bornkamm, G. W. (1985). Aberrant c-myc RNAs of Burkitt's lymphoma cells have longer half-live.EMBO J. 4:3717–3725.
Shtivelman, E., Lifshitz, B., Gale, R. P. and Ganaani, E. (1985). A fused transript of the abl and bcr genes in chronic myelogenous leukemia.Nature 315:550–554.
Reddy, E. P., Reynolds, R. K., Santos, E. and Barbacid, M. (1982). A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.Nature 300:149–152.
Tabin, C. J., Bradley, S., Bargman, C., Weinberg, R., Papageorge, A., Scolnick, E., Dhar, R., Lowr, D. and Chang, E. (1982). Mechanism of activation of human oncogene.Nature 300:143–149.
Taparowsky, E., Suard, Y., Fasano, O., Simizu, K., Goldfard, M. and Wigler, M. (1982). Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.Nature 300:762–765.
Yuasa, Y., Srivastava, S. K., Dunn, C. Y., Rhim, J. S., Reddy, E. P. and Aaronson, S. A. (1983). Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.Nature 303:775–779.
Bos, J. L., Toksoz, D., Marshall, C. J., Verlaan-De Vries, M., Veeneman, G. H., Van Der Eb, A. J., Van Boom, J. H., Janssen, J. W. G. and Steenvoorden, A. C. M. (1985). Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia.Nature 315:726–730.
Seeburg, P. H., Colby, W. W., Hayflick, J. S., Capon, D. J., Goeddel, D. V. and Levinson, A. D. (1984). Biological properties of human c-Ha-rasl genes mutated at codon 12.Nature 312:71–75.
Fasano, O., Aldrich, T., Tamanoi, F., Taparowdky, E., Furth, M. and Wigler, M. (1984). Analysis of the transforming potential of the human H-ras gene by random mutagenesis.Proc. Natl. Acad. Sci. USA 81:4008–4012.
Alitalo, K. (1985). Amplification of cellular oncogenes in cancer cells.Trends in Biochemical Sciences 10:194–197.
Aoseoki, J. G., Rosen, C. A. and Haseltine, W. A. (1984). Trans-acting transcriptional activation of the long terminal repeat of human T lymphotripic viruses in infected cells.Science 225:381–385.
Gaynor, R. B., Hillman, D. and Berk, A. J. (1984). Adenovirus early region 1A protein activates transcription of a nonviral gene introduced into mammalian cells by infection or transfection.Proc. Natl. Acad. Sci. USA 81:1193–1197.
Borrelli, E., Hen, R. and Chambon, P. (1984). Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription.Nature 312:608–615.
Mechler, B. M., McGinnis, W. and Gehring, W. J. (1985). Molecular cloning of lethal (2) giant larvae, a recessive oncogene of Drosophila melanogaster.EMBO J. 4:1551–1557.
Weinstein, I. B. (1981). Current concepts and controversies in chemical carcinogenesis.J. Supp. St. Cell Biochem. 17:99–120.
Slaga, T. J. (1983). Cellular and molecular mechanisms of tumour promotion.Cancer Surveys 2:595–612.
Varshavsky, A. (1981). Phorbol ester dramatically increases incidence of methorexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion.Cell 25:561–571.
Parry, J. M., Parry, E. M. and Barrett, J. C. (1981). Tumor promoters induce mitotic aneuploidy in yeast.Nature 294:263–265.
Colburn, N. H., Former, B. F., Nelson, K. A. and Yaspa, S. H. (1979). Tumor promoter induces anchorage independent irreversibly.Nature 281:589–591.
Fischer, P. B. and Weinstein, I. B. (1979). Chemical viral interactions and multistep aspects of cell transformation. In:Molecular and Cellular Aspects of Carcinogen Screening Tests (R. Montesano, H. Bartsch and L. Tomates, Eds.), IARC Scientific Publications, pp. 113–131.
Kinsella, A. R. and Radman, M. (1978). Tumor promoter induces sister chromatid exchanges: relevance to mechanisms of carcinogenesis.Proc. Natl. Acad. Sci. USA 75:6149–6153.
Hsiao, W.-L. W., Cattoni-Celli, S. and Weinstein, I. B. (1984). Effects of 5-azacytidine on the progressive nature of cell transformation.Science 226:552–555.
Sachs, L. (1978). Control of normal cell differentiation and the phenotypic reversion of malignancy in myeloid leukemia.Nature 274:535–539.
Mintz, B. and Illmensee, K. (1975). Normal genetically mosaic mice produced from malignant teratocarcinoma cells.Proc. Natl. Acad. Sci. USA 77:3585–3589.
Kennedy, A. R., Cairns, J. and Little, J. B. (1984). Timing of the steps in transformation of C3H 10T1/2 cells by X-irradiation.Nature 307:85–86.
Boehm, T. L. J. and Drahousky, D. (1983). Alteration of enzymatic methylation of DNA cytosines by chemical carcinogens: a mechanism involved in the initiation of carcinogenesis.J. Nat. Cancer Inst. 71:429–433.
Wilson, V. L. and Jones, P. A. (1983). Inhibition of DNA methylation by chemical carcinogenesisin vitro.Cell 32:239–246.
Hoffman, R. M. (1984). Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis.Biochem. Biophys. Acta 738:49–87.
Feinberg, A. P. and Vogelstein, M. (1983). Hypomethylation of ras oncogenes in primary human cancer.Biochem. Biophys. Res. Comm. 111:47–54.
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Spandidos, D.A. A unified theory for the development of cancer. Biosci Rep 6, 691–708 (1986). https://doi.org/10.1007/BF01116536
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DOI: https://doi.org/10.1007/BF01116536