Abstract
Ways in which other transport systems may compensate for one that is genetically defective are considered. Comparisons of the transport systems of organelles (here the lysosome) with the transport system at the plasma membrane has significant implications for chemotherapy.
Similar content being viewed by others
References
Gahl, W. A., Tietze, F., Bashan, N., Steinherz, R. and Schulman, J. D. (1982).J. Biol. Chem. 257:9570–9575.
Pisoni, R. L., Thoene, J. G. and Christensen H. N. (1985)J. Biol. Chem. 260:4791–4798.
Christensen, H. N. (1984).Biochim. Biophys. Acta 779:255–269.
Reeves, J. P. (1979).J. Biol. Chem. 254:8914–8921.
Gahl, W. A., Reed, G. F., Thoene, J. G., Schulman, J. d., Rizzo, W. B., Jonas, A. J., Denman, D. W., Schlesselman, J. J., Corden, B. J. and Schneider J. A. (1987).N. Engl. J. Med. 316:971–977.
Christensen, H. N. and Antonioli., J. A. (1969).J. Biol. Chem. 244:1497–1504.
Christensen, H. N., Handlogten, M. E. and Thomas, E. L. (1969).Proc. Nat. Acad. Sci. U.S. 63:948–955.
Pisoni, R. L., Thoene, J. G., Lemons, R. M. and Christensen, H. N. (1978a).J. Biol. Chem. 262:15011–15018.
Lemons, R., Pisoni, R. L., Christensen, H. N., and Thoene, J. G. (1986).Biochim. Biophys. Acta,884:429–434.
Christensen, H. N. (1989).Methods in Enzymol., in press.
Pisoni, R. L., Flickinger, K. S., Thoene, J. G. and Christensen, H. N. (1987b).J. Biol. Chem. 262:6010–6017.
Collarini, E. J., Pisoni, R. L., and Christensen, H. N. (1988).FASEB J. (in press).
Makowske, M. and Christensen, H. N. (1982).J. Biol. Chem. 257:5663–5670.
Christensen, H. N. and Makowske, M. (1983).Life Sci. 33:2255–2267.
Stewart, B. H., Collarini, E. J., Pisoni, R. L., and Christensen, H. N. (1988).FASEB J. (in press).
Bernar, J., Tietze, F., Kohn, L., Bernardini, I., Harper, G. S., Grollman, E. F., and Gahl, W. A. (1986).J. Biol. Chem. 261:17107–17112.
Asatoor, A. M., Cheng, B., Edwards, K. D. G., Lant, A. F., Mattews, D. M., Milne, M. D., Navab, F. and Richards, A. J. (1970).Gut. 11:380–387.
Adibi, S. A., Fekl, W., Furst, P. and Oemke, M. (1987). InBeitrage zur Infusions Therapie und Klinische Ehnahrüng., Vol. 17, S. Karger, Basel.
Sepúlveda, F. V. and Pearson, J. D. (1985).J. Cell. Physiol. 123:144–150.
White, M. F., Gazzola, G. C. and Christensen, H. N. (1982).J. Biol. Chem. 257: 4443–4449.
Jaegger, P., Portmann, L., Saunders, A., Rosenberg, L. E. and Thier, S. O. (1987).N. Engl. J. Med. 314:1120–1123.
Gaul, G. E., Wada, Y., Schneiderman, K., Rassin, D. K., Tallan, H. H. and Sturman, J. A. (1971).Pediatr. Res. 5:265–273.
Van Winkle, L. J., Campione, A. L. and Gorman, J. M. (1988).J. Biol. Chem. 263 (in press). Cited with permission of the authors.
Gandolfi, S. A., Petronini, R. G. and Borghetti, A. F. (1985).Trans. Biochem. Soc. 13: 701–702.
Handlogten, M. E., Garcia-Cañero, R., Lancaster, K. T. and Christensen, H. N. (1981).J. Biol. Chem. 256:7905–7909.
Dudeck, K. L., Dudenhausen, E. E., Chiles, T. C., Fafournoux, P. and Kilberg, M. S. (1987).J. Biol. Chem. 262:12565–12569.
Harper, G. S., Kohn, L. D.,Bernardini, I., Bernar, J., Tietze, F. and Gahl, W. A. (1988).J. Biol. chem. 263 (in press).
Lieve, L. and Davis, B. D. (1965).J. Biol. Chem. 240:4362–4369
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Christensen, H.N. Amino acid transport systems of lysosomes: Possible substitute utility of a surviving transport system for one congenitally defective or absent. Biosci Rep 8, 121–129 (1988). https://doi.org/10.1007/BF01116456
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01116456