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An experiment in enzyme evolution studies withPseudomonas aeruginosa amidase

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Abstract

The regulation of amidase synthesis inP. aeruginosa is under positive control. This review describes the experimental evolution of amidase and its regulator protein for the hydrolysis of novel substrates and experiments to elucidate the mechanism of the control system.

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References

  1. Mortlock, R. P. (1984)Microorganisms as Model Systems for Studying Evolution. Plenum, New York.

    Google Scholar 

  2. Jacob, F. and Monod J. (1961).J. Mol. Biol. 3:318.

    Google Scholar 

  3. Holloway, B. W. (1955).J. Gen. Microbiol. 13:572.

    Google Scholar 

  4. Den Dooren de Jong., L. E. (1925).Bijdrage tot de kennis van het mineralsatiesproces, Dissertation, Rotterdam.

  5. Clarke, P. H. and Meadow, P. W. (1959).J. Gen. Microbiol. 20:144.

    Google Scholar 

  6. Kelly, M. and Clarke, P. H. (1962).J. Gen. Microbiol. 27:305.

    Google Scholar 

  7. Clarke, P. H. (1972).J. Gen. Microbiol. 71:241.

    Google Scholar 

  8. Brammar, W. J. and Clarke, P. H. (1964).J. Gen. Microbiol. 37:307.

    Google Scholar 

  9. Brammar, W. J., Clarke, P. H. and Skinner, A. J. (1967).J. Gen. Microbiol. 47:87.

    Google Scholar 

  10. Skinner, A. J. and Clarke, P. H. (1968).J. Gen. Microbiol. 50:183.

    Google Scholar 

  11. Clarke, P. H. and Tata, R. (1973).J. Gen. Microbiol. 75:231.

    Google Scholar 

  12. Brown, P. R. and Tata, R. (1987).J. Gen. Microbiol. 133:1527.

    Google Scholar 

  13. Day, M., Potts., J. R. and Clarke, P. H. (1975).Genet. Res. Camb. 25:71.

    Google Scholar 

  14. Holloway, B. W. (1986). In:The Bacteria Vol. 10, (Sokatch, J. R.. ed.) Academic Press, New York, pp. 217–249.

    Google Scholar 

  15. O'Hoy, K. and Krishnapillai, V. (1987).Genetics,115;611.

    Google Scholar 

  16. Sambanthamurthi, R. (1983).Genetic studies with Pseudomonas aeruginosa, Ph.D. Thesis, University of London.

  17. Brown, J. E., Brown, P. R. and Clarke, P. H. (1969).J. Gen. Microbiol. 57:273.

    Google Scholar 

  18. Brown, J. E., and Clarke, P. H. (1970).J. Gen. Microbiol. 64:329.

    Google Scholar 

  19. Clarke, P. H. and Lilly, M. D. (1969). In:Microbial Growth 19th symposium of Society for General Microbiology, Cambridge University Press. pp. 113–159.

  20. Hall, B. G. and Clarke, N. D. (1977).Genetics 85:193 (1977).

    Google Scholar 

  21. Smyth, P. F. and Clarke, P. H. (1975a).J. Gen. Microbiol. 90:81.

    Google Scholar 

  22. Beckwith, J. and Rossow, P. (1974).Ann. Rev. Genet. 8:1.

    Google Scholar 

  23. Sadler, J. and Novick, A. (1965).J. Mol. Biol. 12:305.

    Google Scholar 

  24. Farin, F. and Clarke, P. H. (1978). J. Bacteriol.135:379.

    Google Scholar 

  25. Smyth, P. F. and Clarke, P. H. (1975b).J. Gen. Microbiol. 90:91.

    Google Scholar 

  26. Hall, B. G. and Hart, D. L. (1974).Genetics 76:391.

    Google Scholar 

  27. Betz, J. L., Brown, J. E., Clarke, P. H. and Day, M. (1974).Genet. Res. Camb. 23:335.

    Google Scholar 

  28. Betz, J. L. and Clarke, P. H. (1972).J. Gen. Microbiol. 73:161.

    Google Scholar 

  29. Turberville, C. and Clarke, P. H. (1981).FEMS Microbiology Lett. 10:87.

    Google Scholar 

  30. Paterson, A. and Clarke, P. H. (1979).J. Gen. Microbiol. 114:75.

    Google Scholar 

  31. Brown, P. R. and Clarke, P. H. (1972).J. Gen. Microbiol. 70:287.

    Google Scholar 

  32. Brown, P. R., Gregoriou, M. and Tata, R., (1978).Mol. Gen. Genet. 165:213.

    Google Scholar 

  33. Ambler, R. P., Auffret, A. D. and Clarke, P. H. (1987).FEBS Lett. 215:285.

    Google Scholar 

  34. Brown, P. R., Smyth, M. J., Clarke, P. H. and Rosemeyer, M. A. (1973).Eur. J. Biochem. 34:177.

    Google Scholar 

  35. Holloway, M. R. and Ticho, T. (1979).FEBS Lett. 106:185.

    Google Scholar 

  36. Hollaway, M. R., Clarke, P. H. and Ticho, T. (1980).Biochem. J. 191:811.

    Google Scholar 

  37. Drew, R. E., Clarke, P. H. and Brammar, W. J. (1980).Mol. Gen. Genet.,177:311.

    Google Scholar 

  38. Clarke, P. H., Drew, R. E., Turberville, C., Brammar, W. J., Ambler, R. P. and Auffret, A. D. (1981).Biosci. Rep. 1:299.

    Google Scholar 

  39. Brammar, W. J., Charles, I. G., Matfield, M., Cheng-Pin, L., Drew, R. E. and Clarke, P. H. (1987).FEBS Lett. 215:291.

    Google Scholar 

  40. Drew, R. E. (1984).J. Gen. Microbiol. 130:3101.

    Google Scholar 

  41. Cousens, D. J., Clarke, P. H. and Drew, R. E. (1987).J. Gen. Microbiol. 133:2041.

    Google Scholar 

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Author notes

  1. Patricia H. Clarke

    Present address: , Glebe House, School Hill, GL7 2LS, Cirencester, Gloucestershire

Authors and Affiliations

  1. Department of Biochemistry, University College London, Gower Street, WC1E 6BT, London, UK

    Patricia H. Clarke & Robert Drew

Authors
  1. Patricia H. Clarke
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  2. Robert Drew
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Clarke, P.H., Drew, R. An experiment in enzyme evolution studies withPseudomonas aeruginosa amidase. Biosci Rep 8, 103–120 (1988). https://doi.org/10.1007/BF01116455

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  • DOI: https://doi.org/10.1007/BF01116455

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