Skip to main content
SpringerLink
Log in

Lipolytic and adenyl-cyclase-stimulating activity ofN α-trinitrophenyl glucagon: Comparison with other glucagon derivatives modifed at the amino terminus

  • Published:
Bioscience Reports

Abstract

The trinitrophenyl (TNP) derivative of glucagon has less [ipolytic activity and potency than the carbamyl derivative. TheN α,ε-acetyl derivative has slightly less activity than the TNP derivative. In contrast to liver, where the TNP derivative fails to stimulate adenyi cyciase, all the derivatives stimulate this enzyme in the adipocyte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cote TE & Epand RM (1979) Biochim. Biophys. Acta582, 295–306.

    PubMed  Google Scholar 

  2. Epand RM, Epand RF & Gray V (1973) Arch. Biochem. Biophys.154, 132–136.

    PubMed  Google Scholar 

  3. Cushman SW (1970) J. Cell Biol.46, 326–241.

    PubMed  Google Scholar 

  4. Ho R-J (1970) Anal. Biochem.36, 105–113.

    PubMed  Google Scholar 

  5. McKell DW & Jarett J (1970) J. Cell. Biol.46, 417–432.

    Google Scholar 

  6. Ho H-J & Sutherland EW (1975) Proc. Natl. Acad. Sci. U.S.A.72, 1773–1777.

    PubMed  Google Scholar 

  7. Gilman AG (1970) Proc. Natl. Acad. Sci. U.S.A.67, 305–312.

    PubMed  Google Scholar 

  8. Lowry OH, Rosebrough NJ, Farr AL & Randall RJ (1951) J. Biol. Chem.193, 265–275.

    PubMed  Google Scholar 

  9. Lin MC, Wright DE, Hruby VJ & Rodbell M (1975) Biochemistry14, 1559–1563.

    PubMed  Google Scholar 

  10. Khan BA, Bregman MD, Nugent CA, Hruby VJ & Brendel K (1980) Biochem. Biophys. Res. Commun.93, 729–736.

    PubMed  Google Scholar 

  11. Bregman MD & Hruby VJ (1979) FEBS Lett.101, 191–194.

    PubMed  Google Scholar 

  12. Faloona GR, Marco J & Unger RH (1970) Fed. Proc.29, 735.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Rockefeller University, 10021, New York, NY, USA

    Emile Jean-Baptiste & Martin A. Rizack

  2. Department of Biochemistry, McMaster University, L8N 3Z5, Hamilton, Ontario, Canada

    Richard M. Epand

Authors
  1. Emile Jean-Baptiste
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin A. Rizack
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard M. Epand
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jean-Baptiste, E., Rizack, M.A. & Epand, R.M. Lipolytic and adenyl-cyclase-stimulating activity ofN α-trinitrophenyl glucagon: Comparison with other glucagon derivatives modifed at the amino terminus. Biosci Rep 2, 163–167 (1982). https://doi.org/10.1007/BF01116379

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01116379

Keywords

Search

Navigation