Skip to main content
SpringerLink
Log in

DNA sequencing and gene structure

Noel lecture, 8 December 1980

  • Published:
Bioscience Reports

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Gilbert W & Müller-Hill B (1966) Isolation of thelac repressor. Proc. Natl. Acad. Sci. U.S.A.56, 1891–1898.

    Google Scholar 

  2. Gilbert W & Müller-Hill B (1967), Thelac operator is DNA. Proc. Natl. Acad. Sci. U.S.A.58, 2415–2421.

    PubMed  Google Scholar 

  3. Gilbert W & Maxam A (1973) The nucleotide sequence of thelac operator. Proc. Natl. Acad. Sci. U.S.A.70, 3581–3584.

    PubMed  Google Scholar 

  4. Gilbert W, Maizels N & Maxam A (1975) Sequences of controlling regions of theE. coli lactose operator. Genetics79, 227.

    Google Scholar 

  5. Dickson RC, Abelson J, Barnes WM & Reznikoff WS (1975) Genetic regulation: the lac control region. Science187, 27–35.

    PubMed  Google Scholar 

  6. Gilbert W, Maxam A & Mirzabekov A (1976) Contacts between thelac repressor and DNA revealed by methylation. InControl of Ribosome Synthesis, pp 139–148, Alfred Benzon Symposium 9, Munksgaard.

  7. Maxam AM & Gilbert W (1977) A new method for sequencing DNA. Proc. Natl. Acad. Sci. U.S.A.74, 560–564.

    PubMed  Google Scholar 

  8. Tonegawa S, Maxam AM, Tizard R, Bernard O & Gilbert W (1978) Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain. Proc. Natl. Acad. Sci. U.S.A.75, 1485–1489.

    PubMed  Google Scholar 

  9. Maxam AM & Gilbert W (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods in Enzymology65, 499–560.

    PubMed  Google Scholar 

  10. Sanger F & Coulson AR (1978) The use of thin acrylamide gels for DNA sequencing. FEBS Lett.87, 107–110.

    PubMed  Google Scholar 

  11. Farabaugh PJ (1978) Sequence of thelacI gene. Nature274, 765–769.

    PubMed  Google Scholar 

  12. Beyreuther K, Adler K, Fanning E, Murray C, Klemm A & Geisler N (1975) Amino-acid sequence oflac repressor fromEscherichia coli. Eur. J. Biochem.59, 491–509.

    PubMed  Google Scholar 

  13. Coulondre C, Miller JH, Farabaugh PJ & Gilbert W (1978) Molecular basis of base substitution hotspots inEscherichia coli. Nature274, 775–780.

    PubMed  Google Scholar 

  14. Lindahl T, Ljungquist S, Siegert W, Nyberg B & Sperens B (1977) DNAN-glycosidases. J. Biol. Chem.252, 3286–3294.

    PubMed  Google Scholar 

  15. Sutcliffe JG (1978) Nucleotide sequence of the ampicillin resistance gene ofEscherichia coli plasmid pBR322. Proc. Natl. Acad. Sci. U.S.A.75, 3737–3741.

    Google Scholar 

  16. Ambler RP & Scott GK (1978) Partial amino acid sequence of penicillinase coded byEscherichia coli plasmid R6K. Proc. Natl. Acad. Sci. U.S.A.75, 3732–3736.

    PubMed  Google Scholar 

  17. Sutcliffe JG (1978) Complete nucleotide sequence of theEscherichia coli plasmid pBR322. cold Spring Harbor Symposia on Quantitative Biology43, 77–90.

    Google Scholar 

  18. For a review, see: Yanofsky C (1981) Attenuation in the control of expression of bacterial operons. Nature289, 751–758.

    PubMed  Google Scholar 

  19. Tilghman SM, Tiemeier DC, Seidman JG, Peterlin BM, Sullivan M, Maizel JV & Leder P (1978) Intervening sequence of DNA identified in the structural portion of a mouse β-globin gene. Proc. Natl. Acad. Sci. U.S.A.75, 725–729.

    PubMed  Google Scholar 

  20. Konkel DA, Tilghman SM & Leder P (1978) The sequence of the chromosomal mouse β-globin major gene: homologies in capping, splicing and poly(A) sites. Cell15, 1125–1132.

    PubMed  Google Scholar 

  21. Brack S & Tonegawa S (1977) Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart. Proc. Natl. Acad. Sci. U.S.A.74, 5652–5656.

    PubMed  Google Scholar 

  22. Breathnach R, Mandel JL & Chambon P (1977) Ovalbumin gene is split in chicken DNA. Nature270, 314–319.

    PubMed  Google Scholar 

  23. Berget SM, Moore C & Sharp PA (1977) Spliced segments at the 5′ terminus of adenovirus 2 late mRNA. Proc. Natl. Acad. Sci. U.S.A.74, 3171–3175.

    PubMed  Google Scholar 

  24. Chow LT, Gelinas RE, Broker TR & Roberts RJ (1977) An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA. Cell12, 1–8.

    PubMed  Google Scholar 

  25. Gilbert W (1978) Why genes in pieces? Nature271, 501.

    PubMed  Google Scholar 

  26. Bernard O, Hozumi N & Tonegawa S (1978) Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell15, 1133–1144.

    PubMed  Google Scholar 

  27. Sakano H, Rogers JH, Hüppi K, Brack C, Traunecker A, Maki R, Wall R & Tonegawa S (1979) Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments. Nature277, 627–633.

    PubMed  Google Scholar 

  28. Honjo T, Obata M, Yamawaki-Kataoka Y, Kataoka T, Kawakami T, Takahashi N & Mano Y (1979) Cloning and complete nucleotide sequence of mouse immunoglobin γ1 chain gene. Cell18, 559–568.

    PubMed  Google Scholar 

  29. Stein JP, Catterall JF, Kristo P, Means AR & O'Malley BW (1980) Ovomucoid intervening sequences specify functional domains and generate protein polymorphism. Cell21, 681–687.

    PubMed  Google Scholar 

  30. Yamado Y, Avvedimento VE, Mudryj M, Ohkubo H, Vogeli G, Irani M, Pastan I & de Crombrugghe B (1980) The collagen gene: evidence for its evolutionary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell22, 887–892.

    PubMed  Google Scholar 

  31. Doolittle WF (1978) Genes in pieces: were they ever together? Nature272, 581.

    Google Scholar 

  32. Lomedico P, Rosenthal N, Efstratiadis A, Gilbert W, Kolodner R & Tizard R (1979) The structure and evolution of the two nonlllalic rat preproinsulin genes. Cell18, 545–558.

    PubMed  Google Scholar 

  33. Early P, Rogers J, Davis M, Calame K, Bond M, Wall R & Hood L (1980) Two mRNAs can be produced from a single immunoglobin μ gene by alternative RNA processing pathways. Cell20, 313–319.

    PubMed  Google Scholar 

  34. Perler F, Efstratiadis A, Lomedico P, Gilbert W, Kolodner R & Dodgson J (1980) The evolution of genes: the chicken preproinsulin gene. Cell20, 555–566.

    PubMed  Google Scholar 

  35. Jung A, Sippel AE, Grez M & Schütz G (1980) Exons encode functional and structural units of chicken lysozyme. Proc. natl. Acad. Sci. U.S.A.77, 5759–5763.

    PubMed  Google Scholar 

  36. Craik CS, Buchman SR & Beychok S (1980) Characterization of globin domains: heme binding to the central exon product. Proc. Natl. Acad. Sci. U.S.A.77, 1384–1388.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Harvard University, The Biological Laboratories, 02138, Cambridge, Massachusetts, USA

    Walter Gilbert

Authors
  1. Walter Gilbert
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gilbert, W. DNA sequencing and gene structure. Biosci Rep 1, 353–375 (1981). https://doi.org/10.1007/BF01116186

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01116186

Keywords

Search

Navigation