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Somatostatin concentration and binding in the rat hypothalamus and striatum during severe insulin-induced hypoglycemia

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Abstract

Hypoglycemia was induced by administration of insulin (40 I.U./kg) to 24 h fasted rats. Somatostatinlike immunoreactivity (SLI) and125I-Tyr11-somatostatin binding were measured in the striatum and hypothalamus at the onset of hypoglycemic coma (5–10 min). No significant changes in SLI concentration were detected in either site although the total number of specific somatostatin receptors in the striatum membranes, but not in the hypothalamus, decreased in insulin-injected rats when compared with the control group.

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Authors and Affiliations

  1. Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, 28871 Alcalá de Henares, Madrid, Spain

    M. N. Rodriguez-Sanchez & E. Arilla

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  1. M. N. Rodriguez-Sanchez
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  2. E. Arilla
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Rodriguez-Sanchez, M.N., Arilla, E. Somatostatin concentration and binding in the rat hypothalamus and striatum during severe insulin-induced hypoglycemia. Biosci Rep 9, 199–206 (1989). https://doi.org/10.1007/BF01115996

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  • DOI: https://doi.org/10.1007/BF01115996

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