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Effects of alloxan-induced diabetes on somatostatin binding to cytosolic components of rabbit gastric fundic mucosa

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Bioscience Reports

Abstract

Diabetes was induced by administration of alloxan (150 mg/Kg) to 24 h-fasted rabbits. Somatostatinlike immunoreactivity (SLI) and cytosolic binding sites for somatostatin in gastric fundic mucosa were studied using radiolabelled Tyr11-somatostatin. Three months after the onset of the disease, the specific binding of somatostatin to these sites was seen to be significantly lower, due to a reduction in the number (but not the affinity) of specific somatostatin binding sites of high-affinity and a disappearance of the specific, somatostatin binding sites of low-affinity. These changes were associated with an increase in the SLI concentration in both gastric fundic mucosa and plasma.

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Authors and Affiliations

  1. Departmento de Bioquimica y Biologia Molecular Facultad de Medicina, Universidad de Alcala de Henares, Madrid, Spain

    L. G. Guijarro, M. P. Lopez-Ruiz, J. C. Prieto & E. Arilla

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  1. L. G. Guijarro
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  2. M. P. Lopez-Ruiz
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  3. J. C. Prieto
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  4. E. Arilla
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Guijarro, L.G., Lopez-Ruiz, M.P., Prieto, J.C. et al. Effects of alloxan-induced diabetes on somatostatin binding to cytosolic components of rabbit gastric fundic mucosa. Biosci Rep 8, 233–240 (1988). https://doi.org/10.1007/BF01115040

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  • DOI: https://doi.org/10.1007/BF01115040

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