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The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids

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Abstract

In 12 h fasted rats, rates of muscle protein synthesis were stimulated by refeeding for 1 h and by intragastric or intravenous infusion of an amino acid plus glucose mixture for 1 hr, but not by intravenous infusion of amino acids alone for 1 h. Intravenous injection of anti-insulin serum suppressed the response to feeding and to intragastric infusion, but not to intravenous infusion. It is concluded that the response of muscle protein synthesis to food intake is mediated by both insulin and amino acids acting in concert.

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Authors and Affiliations

  1. Clinical Nutrition and Metabolism Unit, Hospital for Tropical Diseases, 4 St. Pancreas Way, NW1 2PE, London

    V. R. Preedy & P. J. Garlick

  2. Cardiothoracic Institute, 2 Beaumont Street, W1N 2DX, London

    V. R. Preedy

  3. Rowett Research Institute, Bucksburn, AB2 9SB, Aberdeen

    P. J. Garlick

Authors
  1. V. R. Preedy
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  2. P. J. Garlick
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Preedy, V.R., Garlick, P.J. The response of muscle protein synthesis to nutrient intake in postabsorptive rats: The role of insulin and amino acids. Biosci Rep 6, 177–183 (1986). https://doi.org/10.1007/BF01115004

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  • DOI: https://doi.org/10.1007/BF01115004

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