Abstract
Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.
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Kemp, L.M., Brickell, P.M., La Thangue, N.B. et al. Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus. Biosci Rep 6, 945–951 (1986). https://doi.org/10.1007/BF01114970
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DOI: https://doi.org/10.1007/BF01114970