Bioscience Reports

, Volume 9, Issue 6, pp 737–745 | Cite as

Export of proteins across membranes: The helix reversion hypothesis

  • U. P. Shinde
  • T. N. Guru Row
  • Y. R. Mawal
Short Papers


A model is presented which explains the biological role of the leader peptide in protein export. Along the lines of this model, the conformational changes of a protein with environment serves as a general mechanism for translocation. The leader peptide in the cytoplasm takes a hairpin like conformation which reverts to an extended helix upon integration into the membrane. The essential features of this model are in accord with recent results of protein export.

Key Words

protein export conformational changes leader peptides hairpin helix 


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Copyright information

© Plenum Publishing Corporation 1989

Authors and Affiliations

  • U. P. Shinde
    • 1
  • T. N. Guru Row
    • 2
  • Y. R. Mawal
    • 3
  1. 1.Division of Chemical EngineeringNational Chemical LaboratoryPuneIndia
  2. 2.Division of Physical ChemistryIndian Institute of ScienceBangalore
  3. 3.Division of Biochemical Sciences, Division of Chemical EngineeringNational Chemical LaboratoryPuneIndia

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