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C\(\bar l\)r and C\(\bar l\)s subcomponents of human complement: Two serine proteinases lacking the ‘histidine-loop’ disulphide bridge

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Bioscience Reports

Abstract

The N-terminal amino acid sequence of human C\(\bar l\)s b chain has been extended to 52 residues. The histidine residue involved in the charge-relay system is located at position 38, whereas the ‘histidine-loop’ disulphide bridge is missing. So far, human complement subcomponents C\(\bar l\)r and C\(\bar l\)s are the only known mammalian serine proteinases lacking this disulphide bridge.

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Author notes

  1. Gerard J. Arlaud

    Present address: D. R. F./Biologie Moleculaire et Cellulaire, C.E.N.G. 85X, 38041, Grenoble-cedex, France

Authors and Affiliations

  1. Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK

    Gerard J. Arlaud & Jean Gagnon

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  1. Gerard J. Arlaud
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  2. Jean Gagnon
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Arlaud, G.J., Gagnon, J. C\(\bar l\)r and C\(\bar l\)s subcomponents of human complement: Two serine proteinases lacking the ‘histidine-loop’ disulphide bridge. Biosci Rep 1, 779–784 (1981). https://doi.org/10.1007/BF01114800

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  • DOI: https://doi.org/10.1007/BF01114800

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