Abstract
The effect of peptide histidine valine-42 (PHV-42) on gastric acid secretion was studied in man. PHV-42 was infused into 5 healthy volunteers at a dose of 10 pmol/kg/min. This dose caused a significant stimulation of basal gastric acid and potassium output. there were no significant changes in circulating gastrin throughout the infusion. In 2 subjects with a background of submaximal pentagastrin stimulation, PHV-42 infusion at the same dose did not alter acid secretion in either subject. The previous observation that PHV-42 is found particularly in the stomach and the new finding that it stimulates basal gastric secretion suggest the possibility that PHV-42 could have a role in local control of acid secretion.
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Nikou, G.C., Yiangou, Y., Chrysanthou, B.J. et al. Peptide histidine valine-42 stimulates gastric acid secretion in man. Biosci Rep 9, 369–374 (1989). https://doi.org/10.1007/BF01114690
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DOI: https://doi.org/10.1007/BF01114690