Abstract
A kinetic method is proposed for the multicomponent inhibition of enzyme reactions; this method can be used for the study of the mutual orientation of individual, complementary regions of the active enzyme center.
Similar content being viewed by others
References
E. Fischer, Ber.,27, 2985, 1894.
D. E. Koshland, Federat. Proc.,23, p. 1, 719, 1964.
B. H. Havsteen and G. P. Hess, J. Am. Chem. Soc.,85, 791, 1963.
B. Havsteen, B. Labouesse, and G. P. Hess, J. Am. Chem. Soc.,85, 796, 1963.
P. B. Siegler, H. C. W. Skinner, C. L. Coulter, J. Kallos, H. Braxton, and D. R. Davies, Proc. Natl. Acad. Sci. U. S.,51, 1146, 1964.
A. Y. Moon, J. Mercouroff, and G. P. Hess, J. Biol. Chem.,240, 714, 1965.
A. G. Ogston, Nature,162, 963, 1963.
G. E. Hein and C. Niemann, J. Am. Chem. Soc.,84, 4495, 1962.
B. Zerner and M. L. Bender, J. Am. Chem. Soc.,86, 3669, 1964.
J. R. Knowles, Biochem. J.,95, 180, 1965.
K. J. Laidler, The Chemical Kinetics of Enzyme Action, Clarendon Press, Oxford, 1958.
M. L. Bender, J. Am. Chem. Soc.,84, 2582, 1962.
M. L. Bender and F. J. Kezdy, J. Am. Chem. Soc.,86, 3704, 1964.
I. V. Berezin, G. Ya. Komomiitseva, A. V. Levashov, and K. Martinek, Mol. biologiya,1, 67, 1967.
I. V. Berezin, Kh. Vill, and K. Martinek, DAN SSSR,175, 236, 1967.
I. V. Berezin, Kh. Vill, K. Martinek, and A. K. Yatsimirskii, Mol. biologiya,1, no. 5, 1967.
I. V. Berezin, Kh. Vill, K. Martinek, A. K. Yatsimirskii, and M. S. Khlydova, Mol. biologiya, 1, no. 1, 1967.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Berezin, I.V., Martinek, K. Possibility of studying the topography of an active enzyme center by multicomponent reversible inhibition. Theor Exp Chem 3, 262–264 (1967). https://doi.org/10.1007/BF01112378
Issue Date:
DOI: https://doi.org/10.1007/BF01112378