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CNS prophylaxis of childhood leukemia: What are the long-term neurological, neuropsychological, and behavioral effects?

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Abstract

Current medical treatments for childhood acute lymphoblastic leukemia (ALL) have improved the outlook to where more than 50% can be expected to survive five years or more. The use of CNS prophylaxis has contributed in a significant way to these improved survival statistics by reducing the likelihood of CNS relapses. The literature relating to the potential adverse psychological consequences of CNS prophylaxis, which include cranial radiation therapy (CRT), is reviewed and analyzed. The majority of published papers of children in first remission report that CNS prophylaxis, which include both CRT and intrathecal methotrexate, results in a variety of learning problems in many children who were younger than age 5 when treated. The available literature on the social, emotional, and educational sequelae of childhood ALL is also reviewed.

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Authors and Affiliations

  1. University of Iowa, Iowa City, Iowa

    James A. Stehbens

  2. University of California, Los Angeles, California

    Thomas A. Kaleita

  3. Children's Hospital Medical Center, Cincinnati, Ohio

    Robert B. Noll

  4. Vanderbilt University, Nashville, Tennessee

    William E. MacLean Jr.

  5. Primary Childrens Hospital, Salt Lake City, Utah

    Richard T. O'Brien

  6. Mott Childrens Hospital, Ann Arbor, Michigan

    Mary J. Waskerwitz

  7. University of Southern California School of Medicine, Los Angeles, California

    G. Denman Hammond

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Contributing Childrens Cancer Study Group investigators, institutions, and grant numbers are given in the Appendix. Address reprint requests to the Childrens Cancer Study Group, 440 East Huntington Drive, Suite 300, P.O. Box 60012, Arcadia, California 91066-6012.

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Stehbens, J.A., Kaleita, T.A., Noll, R.B. et al. CNS prophylaxis of childhood leukemia: What are the long-term neurological, neuropsychological, and behavioral effects?. Neuropsychol Rev 2, 147–177 (1991). https://doi.org/10.1007/BF01109052

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