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Information processing, neuropsychological function, and the inherited predisposition to alcoholism

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Abstract

Sons of male alcoholics are at particularly heightened risk for the development of alcoholism. This heightened risk frequently appears in association with increased incidence of conduct disorder or hyperactivity, with deficits in abstract thinking and poor school performance, with abnormalities in cued psychophysiological response, and with increased sensitivity to the putatively stress-response-dampening effects of alcohol intoxication. This risk and its associated features are discussed within the context of a neuropsychological theory, predicated on the notions (1) that deficits in cognitive functions theoretically dependent upon the intact functioning of the prefrontal cortex could underlie manifestation of the idiosyncracies commonly attributed to sons of male alcoholics, and (2) that acute alcohol intoxication could relieve the subjective discomfort associated with the consequences of such deficits.

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References

  • Ackerly, S. S., and Benton, A. L. (1948). Report of a case of bilateral frontal lobe defect.Research on Public Assistance and Research on Nervous and Mental Disorders 27: 479–504.

    Google Scholar 

  • Adrian, M. (1984).Statistics on Alcohol and Drug Use in Canada and Other Countries (Vols. 1 & 2), Addiction Research Centre, Toronto.

    Google Scholar 

  • Alterman, A. I., Bridges, R., and Tarter, R. E. (1986a). Drinking behavior of high risk college men: Contradictory preliminary findings.Alcohol: Clinical and Experimental Research 10: 305–310.

    Google Scholar 

  • Alterman, A. I., Bridges, R., and Tarter, R. E. (1986b). The influence of both drinking and familial risk status on cognitive functioning of social drinkers.Alcoholism: Clinical and Experimental Research 10: 448–451.

    Google Scholar 

  • Alterman, A. I., Gerstley, L. J., Goldstein, G., and Tarter, R. E. (1987). Comparisons of the cognitive functioning of familial and nonfamilial alcoholics.Journal of Studies on Alcohol 48: 425–429.

    PubMed  Google Scholar 

  • Alterman, A. I., Searles, J. S., and Hall, J. G. (1989). Failure to find differences in drinking behavior as a function of familial risk for alcoholism: A replication.Journal of Abnormal Psychology 98: 50–53.

    PubMed  Google Scholar 

  • Aronson, H., and Gilbert, A. (1963). Preadolescent sons of male alcoholics: An experimental study of personality patterning.Archives of General Psychiatry 8: 47–53.

    PubMed  Google Scholar 

  • Begleiter, H., Porjesz, B., Rawlings, R., and Eckardt, M. (1987). Auditory recovery function and P3 in boys at high risk for alcoholism.Alcohol 4: 315–321.

    PubMed  Google Scholar 

  • Begleiter, H., Porjesz, B., and Tenner, M. (1980). Neuroradiological and neurophysiological evidence of brain deficits in chronic alcoholics.Acta Psychiatrica Scandinavia 62 (Suppl. 286): 3–13.

    Google Scholar 

  • Begleiter, H., Porjesz, B., and Bihari, B. (1987). Auditory brainstem potentials in sons of alcoholic fathers.Alcoholism: Clinical and Experimental Research 11: 477–480.

    Google Scholar 

  • Begleiter, H., Porjesz, B., Bihari, B., and Kissin, B. (1984). Event-related brain potentials in boys at risk for alcoholism.Science 225: 1493–1496.

    PubMed  Google Scholar 

  • Begleiter, H., Porjesz, B., Chou, C. L., and Aunon, J. I. (1983). P3 and stimulus incentive value.Psychophysiology 20: 95–101.

    PubMed  Google Scholar 

  • Bohman, M. (1978). Some genetic aspects of alcoholism and criminality: A population of adoptees.Archives of General Psychiatry 35: 269–276.

    PubMed  Google Scholar 

  • Brown, R. A., and Cutter, H. S. G. (1977). Alcohol, customary drinking behavior and pain.Journal of Abnormal Psychology 86: 179–188.

    PubMed  Google Scholar 

  • Buchsbaum, M. S., and Ludwig, A. M. (1978). Effects of sensory input and alcohol administration on visual evoked potentials in normal subjects and alcoholics. In Begleiter, H. (ed.),Biological Effects of Alcohol: Proceedings of the International Symposium on Biological Research in Alcoholism, Zurich, Switzerland, Plenum Press, New York, pp. 561–571.

    Google Scholar 

  • Cadoret, R. J., and Gath, A. (1978). Inheritance of alcoholism in adoptees.British Journal of Psychiatry 132: 252–258.

    Google Scholar 

  • Cadoret, R. J., Cain, C. A., and Grove, W. M. (1980). Development of alcoholism in adoptees raised apart from alcoholic biological relatives.Archives of General Psychiatry 37: 561–563.

    PubMed  Google Scholar 

  • Cantwell, D. P. (1972). Psychiatric illness in the families of hyperactive children.Archives of General Psychiatry 27: 414–417.

    PubMed  Google Scholar 

  • Cloninger, C. R. (1987). Neurogenetic adaptive mechanisms in alcoholism.Science 23: 410–415.

    Google Scholar 

  • Coopersmith, S., and Woodrow, K. (1967). Basal conductance levels of alcoholics and alcoholics.Quarterly Journal of Studies on Alcohol 28: 27–32.

    PubMed  Google Scholar 

  • Cotton, N. S. (1979). The familial incidence of alcoholism: a review.Journal of Studies on Alcohol 40: 89–116.

    PubMed  Google Scholar 

  • Damasio, A. R. (1986). The frontal lobes. In Heilman, K., and Valenstein, E. (eds.),Clinical Neuropsychology, Oxford University Press, Oxford.

    Google Scholar 

  • Donchin, E. (1981) Surprise! ... Surprise?Psychophysiology 18: 493–513.

    PubMed  Google Scholar 

  • Donchin, E., Ritter, W., and McCallum, W. C. (1978). Cognitive psychophysiology: The endogenous components of the ERP. In Callaway, F., Tueting, P., and Koslow, S. H. (eds.),Event-Related Brain Potentials in Man, Academic Press, New York.

    Google Scholar 

  • Drejer, K., Theilgaard, A., Teasdale, T. W., Schulsinger, F., and Goodwin, W. (1985). A prospective study of young men at high risk for alcoholism: Neuropsychological assessment.Alcoholism: Clinical and Experimental Research 9: 498–502.

    Google Scholar 

  • Duncan-Johnson, C. C., and Donchin, E. (1977). Quantifying surprise: the variation of event-related potentials with subjective probability.Psychophysiology 456–467.

  • Elmasian, R., Neville, H., Woods, D., Schuckit, M., and Bloom, F. (1982). Event-related brain potentials are different in individuals at high and low risk for developing alcoholism.Proceedings of the National Academy of Science 79: 7900–7903.

    Google Scholar 

  • Emrick, C. D., and Hansen, J. (1983). Assertions regarding effectiveness of treatment for alcoholism.American Psychologist 38: 1078–1088.

    PubMed  Google Scholar 

  • Eslinger, P. J., and Damasio, A. R. (1985). Severe disturbances of higher cognition after bilateral frontal lobes ablation: patient E.V.R.Neurology 35: 1731–1741.

    PubMed  Google Scholar 

  • Finn, P. R., and Pihl, R. O. (1987). Men at high risk for alcoholism: the effects of alcohol on cardiovascular response to unavoidable shock.Journal of Abnormal Psychology 96: 230–236.

    PubMed  Google Scholar 

  • Finn, P. R., and Pihl, R. O. (1988). Risk for alcoholism: A comparison between two different groups of sons of alcoholics on cardiovascular reactivity and sensitivity to alcohol.Alcoholism: Clinical and Experimental Research 12: 742–747.

    Google Scholar 

  • Finn, P. R., Zeitouni, N. C., and Pihl, R. O. (1990). Effects of alcohol on psychophysiological hyperreactivity to nonaversive and aversive stimuli in men at high risk for alcoholism.Journal of Abnormal Psychology 99: 79–85.

    PubMed  Google Scholar 

  • Fowles, D. C. (1983). Motivational effects of heart rate and electrodermal activity: Implications for research on personality and psychopathology.Journal of Research on Personality 17: 48–71.

    Google Scholar 

  • Freund, G., and Ballinger, W. E., Jr. (1989). Loss of muscarinc and benzodiazepine neuroreceptors from hippocampus of alcohol abusers.Alcoholism: Clinical and Experimental Research 13: 189.

    Google Scholar 

  • Gabrielli, W. F., Jr., and Mednick, S. A. (1983). Intellectual performance in children of alcoholics.Journal of Nervous and Mental Disorders 171: 44–447. Gabrielli, W. F., Jr., Mednick, S. A., Volavka, J., Pollock, V. E., Schulsinger, F., and Itil, T. M. (1982). Electroencephalograms in children of alcoholic fathers.Psychophysiology 19: 404–407.

    Google Scholar 

  • Garfield, Z. H., and McBrearty, J. F. (1970). Arousal level and stimulus response in alcoholics after drinking.Quarterly Journal of Studies on Alcohol 31: 832–838.

    PubMed  Google Scholar 

  • Goldman, P. S., and Nauta, W. J. H. (1977). Columnar distribution of cortico-cortical fibers in the frontal association, limbic and motor cortex of the developing rhesus monkey.Brain Research 122: 393–413.

    PubMed  Google Scholar 

  • Goodwin, D. W., Schulsinger, F., Hermansen, L., Guze, S. B., and Winokur, G. (1973). Alcohol problems in adoptees raised apart from alcoholic biological parents.Archives of General Psychiatry 28: 238–243.

    PubMed  Google Scholar 

  • Goodwin, D. W., Schulsinger, F., Moller, N., Hermansen, L., Winokur, G., and Guze, S. B. (1974). Drinking problems in adopted and non-adopted sons of alcoholics.Archives of General Psychiatry 131: 164–169.

    Google Scholar 

  • Gorenstein, E. E. (1987). Cognitive-perceptual deficit in an alcoholism spectrum disorder.Journal of Studies on Alcohol 48: 310–318.

    PubMed  Google Scholar 

  • Granit, R. (1977).The Purposive Brain, Massachusetts University Press, Cambridge.

    Google Scholar 

  • Gray, J. A. (1982).The Neuropsychology of Anxiety: An Enquiry into the Function of the Septal-Hippocampal System, Oxford University Press, Oxford.

    Google Scholar 

  • Gray, J. A. (19887).The Psychology of Fear and Stress, Cambridge University Press, Cambridge.

  • Halgren, E., Squires, N. K., Wilson, C. L., Rohrbaugh, J. W., Babb, T. L., and Crandell, P. H. (1980). Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events.Science 210: 803–805.

    PubMed  Google Scholar 

  • Harden, P., and Pihl, R. O. Cognitive and behavioral characteristics of adolescent sons of alcoholics. Manuscript submitted for publication.

  • Heath, A. C., and Martin, N. G. (1988). Teenage alcohol use in the Australian Twin Register: Genetic and social determinants of starting to drink.Alcoholism: Clinical and Experimental Research 12: 735–741.

    Google Scholar 

  • Heath, R. G. (1986). The neural substrate for emotion. In Plutchik, R., and Kellerman, H. (eds.),Emotion: Theory, Research and Experience (Vol. 3: Biological Foundations of Emotion), Academic Press, New York, pp.3–36.

    Google Scholar 

  • Hegedus, A. M., Alterman, A. I., and Tarter, R. E. (1984). Learning achievement in sons of alcoholics.Alcoholism: Clinical and Experimental Research 8: 330–333.

    Google Scholar 

  • Hennecke, J. (1984). Stimulus augmenting and field dependence in children of alcoholic fathers.Journal of Studies on Alcohol 45: 486–492.

    PubMed  Google Scholar 

  • Hesselbrock, V. M., Stabenau, J. R., and Hesselbrock, M. N. (1985). Minimal brain dysfunction and neuropsychological test performance in offspring of alcoholics.Recent Developments in Alcoholism 3: 65–82.

    PubMed  Google Scholar 

  • Hinshaw, P. S. (1987). On the distinction between attentional deficits/hyperactivity and conduct problems/aggression in child psychopathology.Psychological Bulletin 101: 443–463.

    PubMed  Google Scholar 

  • Hill, S. Y., Steinhauer, S. R., Park, J., and Zubin, J. (1990). Event-related potential characteristics in children of alcoholics from high density families.Alcoholism: Clinical and Experimental Research 14: 6–16.

    Google Scholar 

  • Hill, S. Y., Steinhauer, S. R., Zubin, J., and Baughman, T. (1988). Event-related potentials as markers for alcoholism risk in high density families.Alcoholism: Clinical Experimental Research 12: 545–554.

    Google Scholar 

  • Hinshaw, S. P. (1987). On the distinction between attentional deficits hyperactivity and conduct problems/aggression in child psychopathology.Psychological Bulletin 101: 443–463.

    PubMed  Google Scholar 

  • Hrubec, Z., and Omenn, G. S. (1981). Evidence of genetic predisposition to alcoholic cirrhosis and psychosis: Twin concordances from alcohol availability, alcohol consumption and demographic data.Journal of Studies on Alcohol 43: 1199–1213.

    Google Scholar 

  • Kaij, L. (1960).Alcoholism in Twins Almquist and Wiksell, Stockholm.

    Google Scholar 

  • Kaamerow, D. B., Pincus, H. A., and MacDonald, D. J. (1986). Alcohol abuse, other drug abuse, and mental disorders in medical practice.Journal of the American Medical Association 225.

  • Kaprio, I., Koskenvuo, M., Langinvainio, H., Romanov, K., Suana, S., and Rose, R. J. (1987). Genetic influences on use and abuse of alcohol: A study of 5638 adult Finnish twin brothers.Alcoholism: Clinical and Experimental Research 349–356.

  • Kiloh, L. G., and Osselton, J. W. (1961).Clinical Electroencephalography, Butterworths, London.

    Google Scholar 

  • Knop, J., Teasdale, T. W., Schulsinger, F., and Goodwin, D. W. (1985). A prospective study of young men at high risk for alcoholism: school behavior and achievement.Journal of Studies on Alcohol. 46: 273–278.

    PubMed  Google Scholar 

  • Lester, D. (1988). Genetic theory: An assessment of the heritability of alcoholism. In Chaudron, C. D., and Wilkinson, D. A. (eds.),Theories on Alcoholism, Addiction Research Foundation, Toronto, pp. 73–102.

    Google Scholar 

  • Levenson, R. W., Oyama, O. N., and Meek, P. S. (1987). Greater reinforcement from alcohol for those at risk: Parental risk, personality risk and sex.Journal of Abnormal Psychology 96: 242–253.

    PubMed  Google Scholar 

  • Lovinger, D. M., White, G., and Weight, F. F. (1989). Ethanol inhibits NMDA-activated ion current in hippocampal neurons.Science 243: 1721–1724.

    PubMed  Google Scholar 

  • Ludwig, A. M., Cain, R. B., and Wikler, A. (1977). Stimulus intensity modulation and alcohol consumption.Journal of Studies on Alcohol 38: 2049–2056.

    PubMed  Google Scholar 

  • Luria, A. R.The Working Brain, Penguin Books, New York.

  • Luria, A. R. (1980).Higher Cortical Functions in Man, Moscow University Press, Moscow.

    Google Scholar 

  • Maclean, P. D. (1986). Ictal symptoms relating to the nature of affects and their cerebral substrate. In Plutchik, R., and Kellerman, H. (eds.),Emotion: Theory, Research and Experience (Vol. 3: Biological Foundations of Emotion), Academic Press, New York, pp. 61–90.

    Google Scholar 

  • Mendelson, J. H., and Mello, N. K. (1979). Biologic concomitants of alcoholism.New England Journal of Medicine 301: 912–921.

    PubMed  Google Scholar 

  • Miller, W. R., and Hester, R. (1986). Inpatient alcoholism treatment: Who benefits?American Psychologist 41: 794–805.

    PubMed  Google Scholar 

  • Milner, B. (1964). Some effects of frontal lobectomy in man. In Warren, J. M., and Akert, K. (eds.),The Frontal Granular Cortex and Behaviour, McGraw-Hill, New York, pp. 313–324.

    Google Scholar 

  • Morrison, J. R., and Stewart, M. A. (1971). A family study of the hyperactive child syndrome.Biological Psychiatry 3: 189–195.

    PubMed  Google Scholar 

  • Morrison, J. R., and Stewart, M. A. (1973). The psychiatric status of the legal families of adopted hyperactive children.Archives of General Psychiatry 28: 888–891.

    PubMed  Google Scholar 

  • Murray, R. M., Clifford, C. A., and Gurling, H. (1983). Twin and adoption studies: How good is the evidence for a genetic role? In Galanter, M. (ed.),Recent Developments in Alcoholism (Vol. 1), Plenum Press, New York, pp. 25–48.

    Google Scholar 

  • Nauta, W. J. H. (1971). The problem of the frontal lobe: a reinterpretation.Psychiatry Research 8: 167–187.

    Google Scholar 

  • Neville, H. J., and Schmidt, A. L. (1985). Event-related brain potentials in subjects at high risk for alcoholism. In Chang, N., and Chao, H. (eds.),Early Identification of Alcohol Abuse (research monograph 17), National Institute of Alcohol Abuse and Alcoholism, Rockville, MD, pp. 228–239.

    Google Scholar 

  • Noll, R., and Zuker, R. (1983).Developmental findings from an alcoholic vulnerability study: The preschool years. Paper presented at the annual meeting of the American Psychological Association, Anaheim, CA.

  • Nylander, I. (1960). Children of alcoholic fathers.Acta Pediatrica Scandinavia 49 (suppl 121).

  • Nylander, I., and Rydelius, P. A. (1982). A comparison between children of alcoholic fathers from excellent versus poor social conditions.Acta Pediatrica Scandinavia 71: 809–813.

    Google Scholar 

  • O'Connor, S., Hesselbrock, V., and Tasman, A. (1986). Correlates of increased risk for alcoholism in young men.Progress in Neuropsychopharmacology and Biological Psychiatry 10: 211–218.

    Google Scholar 

  • Okada, Y. C., Kaufman, L., and Williamson, S. J. (1983). The hippocampal formation as a source of the slow endogenous potentials.Electroencephalography and Clinical Neuropsychology 55: 417–426.

    Google Scholar 

  • Panksepp, J. (1986). The anatomy of emotions. In Plutchik, R., and Kellerman, H. (eds.),Emotion: Theory, Research and Experience (Vol. 3: Biological Foundations of Emotion), Academic Press, New York, pp. 91–124.

    Google Scholar 

  • Parsons, O. A., Sinha, R., and Williams, H. L. (1990). Relationships between neuropsychological test performance and event-related potentials in alcoholic and nonalcoholic samples.Alcoholism: Clinical and Experimental Research 14: 746–755.

    Google Scholar 

  • Peterson, J. B., Finn, P., and Pihl, R. O. (in press), Cognitive dysfunction and the inherited predisposition to alcoholism.Journal of Studies on Alcohol.

  • Peterson, J. B., Pihl, R. O., Seguin, J., and Finn, P.Alcohol-induced heart rate change, family history, and prediction of weekly alcohol consumption by nonalcoholic males. Manuscript submitted for publication.

  • Peterson, J. B., Rothfleisch, J., Zelazo, P. D., and Pihl, R. O. (1990). Acute alcohol intoxication and cognitive functioning.Journal of Studies on Alcohol 51: 114–122.

    PubMed  Google Scholar 

  • Petrides, M., and Milner, B. (1982). Deficits on subject-ordered tasks after frontal- and temporal-lobe lesions in man.Neuropsychologia 20: 249–262.

    PubMed  Google Scholar 

  • Petrie, A. (1978).Individuality in Pain and Suffering (2nd ed), University of Chicago Press, Chicago.

    Google Scholar 

  • Pickens, R. W., Svikis, D. S., McGue, M., Lykken, D. T., Heston, L. L., and Clayton, P. J. (1991). Heterogeneity in the inheritance of alcoholism: A study of male and female twins.Archives of General Psychiatry 48: 19–28.

    PubMed  Google Scholar 

  • Pihl, R. O., and Spiers, P. (1978). Individual characteristics in the etiology of drug abuse.Progress in Experimental Personality Research 8: 93–195.

    PubMed  Google Scholar 

  • Pihl, R. O., Peterson, J. B., and Finn, P. R. (1987).Autonomic Reactivity and neuropsychological deficits in men at high risk for alcoholism. Paper presented at the Fourth Annual Conference on the Treatment of Addictive Behaviours, Bergen, Norway.

  • Pihl, R. O., Peterson, J. B., and Finn, P. R. (1990). The inherited predisposition to alcoholism: Characteristics of sons of male alcoholics.Journal of Abnormal Psychology 99: 291–301.

    PubMed  Google Scholar 

  • Polich, J. M., Armor, D. J., and Braiker, H. B. (1980). Patterns of alcoholism over four years.Journal of Studies on Alcohol 41: 397–416.

    PubMed  Google Scholar 

  • Polich, J., Burns, T., and Bloom, F. E. (1988). P300 and the risk for alcoholism: Family history, task difficulty, and gender.Alcoholism: Clinical and Experimental Research 12: 248–254.

    Google Scholar 

  • Polich, J., and Bloom, F. E. (1988). Event-related brain potentials in individuals at high and low risk for developing alcoholism: Failure to replicate.Alcoholism: Clinical and Experimental Research 12: 368–373.

    Google Scholar 

  • Polich, J., and Bloom, F. E. (1987). P300 from normals and children of alcoholics.Alcohol 4: 301–305.

    PubMed  Google Scholar 

  • Polich, J., Haier, R., Buchsbaum, M., and Bloom, F. E. (1988). Assessment of young men at risk for alcoholism with P300 from a visual discrimination task.Journal of Studies on Alcohol 49: 186–190.

    PubMed  Google Scholar 

  • Pollock, V. E., Gabrielli, W. F., Mednick, S. A., and Goodwin, D. W. (in press). EEG identification of subgroups of men at risk for alcoholism?Psychiatry Research.

  • Pollock, V. E., Volavka, J., Goodwin, W., Gabrielli, W. F., Mednick, S. A. Knop, J., and Schulsinger, F. (in press). Pattern reversal visual evoked potentials after alcohol administration among men at risk for alcoholism.Biological Psychiatry

  • Pollock, V. E., Volavka, J., Goodwin, D. W., Mednick, S. A., Gabrielli, W. F., Knop, J., and Schulsinger, F. (1983). The EEG after alcohol administration in men at risk for alcoholism.Archives of General Psychiatry 40: 857–861.

    PubMed  Google Scholar 

  • Porjesz, B., and Begleiter, H. (1985). Human brain electrophysiology and alcoholism. In Tarter, R. E., and Thiel, D. H. (eds.),Alcohol and the Brain, Plenum, New York, pp. 139–182.

    Google Scholar 

  • Porjesz, B., and Begleiter, H. (1981). Human evoked brain potentials and alcohol.Alcoholism: Clinical and Experimental Research 5: 304–317.

    Google Scholar 

  • Porjesz, B., Begleiter, H., and Samuelly, I. (1980). Cognitive deficits in chronic alcoholics and elderly subjects assessed by evoked brain potentials.Acta Psychiatrica Scandinavia (Suppl. 286): 15–29.

    Google Scholar 

  • Reed, R., Grant, I., and Adams, K. M. (1987). Family history of alcoholism does not predict neuropsychological performance in alcoholics.Alcoholism: Clinical and Experimental Research 11: 340–344.

    Google Scholar 

  • Reiman, E. M., Fusselman, M. J., Fox, P. T., and Raichle, M. E. (1989). Neuroanatomical correlates of anticipatory anxiety.Science 243: 1071–1074.

    PubMed  Google Scholar 

  • Rydelius, P. A. (1978). Methanol intoxication: A differential diagnosis also of current interest in child psychiatric care.Acta Paedopsychiatrica (Basel) 43: 261–265.

    PubMed  Google Scholar 

  • Rydelius, P. A. (1981). Children of alcoholic fathers: Their social adjustment and their health status over 20 years.Acta Pediatrica Scandinavia (Suppl. 286).

  • Rydelius, P. A. (1983a). Alcohol abusing teenage boys: Testing a hypothesis on the relationship between alcohol abuse and social background factors, criminality and personality in teenage boys.Acta Psychiatrica Scandinavia 68: 368–380.

    Google Scholar 

  • Rydelius, P. A. (1983b). Alcohol abusing teenage boys: Testing a hypothesis on alcohol abuse and personality factors, using a personality inventory.Acta Psychiatrica Scandinavia 68: 381–385.

    Google Scholar 

  • Saunders, G. R., and Schuckit, M. A. (1981). MMPI scores in young men with alcoholic relatives and controls.Journal of Nervous and Mental Disorders 169: 456–458.

    Google Scholar 

  • Schaeffer, K. W., Parsons, O. A., and Errico, A. L. (1988). Abstracting deficits and childhood conduct disorder as a function of familial alcoholism.Alcoholism: Clinical Experimental Research 12: 617–618.

    Google Scholar 

  • Schaeffer, K. W., Parsons, O. A., and Yohman, J. R. (1984). Neuropsychological differences between male familial and nonfamilial alcoholics and nonalcoholics.Alcoholism: Clinical and Experimental Research 8: 347–351.

    Google Scholar 

  • Schmidt, A. L., and Neville, H. J. (1984). Event-related brain potentials (ERPs) in sons of alcoholic fathers (abstract).Alcoholism: Clinical and Experimental Research 8: 117.

    Google Scholar 

  • Schuckit, M. A., Butters, N., Lyn, L., and Irwin, M. (1987). Neuropsychologic deficits and the risk for alcoholism.Neuropsychopharmacology 1: 50–53.

    Google Scholar 

  • Schulsinger, F., Knop, J., Goodwin, D. W., Teasdale, T. W., and Mikkelson, U. (1986). A prospective study of young men at high risk for alcoholism: Social and psychological characteristics.Archives of General Psychiatry 93: 755–760.

    Google Scholar 

  • Sher, K. J., and Levenson, R. W. (1982). Risk for alcoholism and individual differences in the stress-response dampening effect of alcohol.Journal of Abnormal Psychology 91: 350–367.

    PubMed  Google Scholar 

  • Sokolov, E. N. (1969). The modeling properties of the nervous system. In Maltzman, I., and Coles, K. (eds.),Handbook of Contemporary Soviet Psychology, Basic Books, New York, pp. 670–704.

    Google Scholar 

  • Steinhauer, S. R., Hill, S. Y., and Zubin, J. (1987). Event-related potentials in alcoholics and their first-degree relatives.Alcohol 4: 307–314.

    PubMed  Google Scholar 

  • Stewart, M. A., de Blois, C. S., and Singer, S. S. (1978). Alcoholism and hyper-activity revisited. A preliminary report.Current Alcohol Research 1–3: 349–357.

    Google Scholar 

  • Tarter, R. E., Alterman, A. I., and Edwards, K. L. (1985). Vulnerability to alcoholism in men: A behavior-genetic perspective.Journal of Studies on Alcohol 46: 329–356.

    PubMed  Google Scholar 

  • Tarter, R. E., Alterman, A. I., and Edwards, K. L. (1988). Neurobehavioural theory of alcoholism etiology. In Chaudron, C. D. and Wilkinson, C. D. (eds.),Theories on Alcoholism, Addiction Research Foundation, Toronto, pp. 73–102.

    Google Scholar 

  • Tarter, R. E., Jacob, T., and Bremer, D. A. (1989). Cognitive status of sons of alcoholic men.Alcoholism: Clinical and Experimental Research 13: 232–235.

    Google Scholar 

  • Tarter, R. E., Hegedus, A. M., Goldstein, G., Shelly, C., and Alterman, A. I. (1984). Adolescent sons of alcoholics: Neuropsychological and personality characteristics.Alcoholism: Clinical and Experimental Research 8: 216–222.

    Google Scholar 

  • Teylor, T. J., and Discenna, P. (1986). The hippocampal memory indexing theory.Behavioral Neuroscience 100: 147–154.

    PubMed  Google Scholar 

  • Teylor, T. J., and Discenna, P. (1985). The role of hippocampus in memory: A hypothesis.Neuroscience and Biobehavioral Review 9: 377–389.

    Google Scholar 

  • Tueting, P., Sutton, S., and Zubin, J. (1971). Quantitative evoked potential correlates of the probability of events.Psychophysiology 7: 385–394.

    Google Scholar 

  • Vinogradova, O. (1961).The Orientation Reaction and Its Neuropsychological Mechanisms, Academic Pedagogical Sciences, Moscow.

    Google Scholar 

  • Vinogradova, O. (1975). Functional organization of the limbic system in the process of registration of information: facts and hypotheses. In Isaacson, R., and Pribram, K. (eds.), TheHippocampus, Neurophysiology, and Behaviour (Vol. 2), Plenum Press, New York, pp. 3–69.

    Google Scholar 

  • Watanabe, T., and Niki, H. (1985). Hippocampal unit activity delayed response in the monkey.Brain Research 325: 241–245.

    PubMed  Google Scholar 

  • Whipple, S., and Noble, E. P. (1986). The effects of familial alcoholism on visual event-related potentials.Psychophysiology 23: 470.

    Google Scholar 

  • Whipple, S. C., Parker, E. S., and Noble, E. P. (1988). An atypical neurocognitive profile in alcoholic fathers and their sons.Journal of Studies on Alcohol 49: 240–244.

    PubMed  Google Scholar 

  • Wilson, J. R., and Nagoshi, C. T. (1988). Adult children of alcoholics: Cognitive and psychomotor characteristicsBritish Journal of Addiction 83: 809–820.

    PubMed  Google Scholar 

  • Wise, R. A., and Bozarth, M. A. (1987). A psychomotor stimulant theory of addictionPsychological Review 94: 469–492.

    PubMed  Google Scholar 

  • Workman-Daniels, K. L., and Hesselbrock, V. M. (1987). Childhood problem behaviour and neuropsychological functioning in persons at risk for alcoholism.Journal of Studies on Alcohol 48: 187–193.

    PubMed  Google Scholar 

  • Zucker, R. A., and Lisansky-Gomberg, E. S. (1986). Etiology of alcoholism reconsidered: The case for a biopsychosocial process.American Psychologist 41: 783–793.

    PubMed  Google Scholar 

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Peterson, J.B., Pihl, R.O. Information processing, neuropsychological function, and the inherited predisposition to alcoholism. Neuropsychol Rev 1, 343–369 (1990). https://doi.org/10.1007/BF01109029

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