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Psychobiological evidence for the distinction between episodic and semantic memory

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Abstract

The evidence for discrete neurobiological mechanisms that underlie episodic and semantic memory is reviewed. Published data from three separate lines of research are considered: studies of human amnesic patients, psychopharmacological studies of normal human subjects, and studies of working and reference memory in rodents, a distinction that is arguably analogous to the episodic/semantic dichotomy. It is concluded that the available evidence does not indicate that episodic and semantic memory are mediated by discrete neural subsystems. An alternative model of human memory is discussed, based on the concept of parallel distributed processing.

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References

  • Baddeley, A. D. (1984). Neuropsychological evidence and the semantic/episodic distinction.The Behavioral and Brain Sciences 7: 238–239.

    Google Scholar 

  • Beatty, W. W., and Bierley, R. A. (1985). Scopolamine degrades spatial working memory but spares spatial reference memory: Dissimilarity of anticholinergic effect and restriction of distal visual cues.Pharmacology, Biochemistry and Behavior 23: 1–6.

    Google Scholar 

  • Beatty, W. W., Bierley, R. A., and Rush, J. R. (1985). Spatial memory in rats: Electroconvulsive shock selectively disrupts working memory but spares reference memory.Behavioral and Neural Biology 44: 403–414.

    PubMed  Google Scholar 

  • Beninger, R., Jhamandas, K., Boegman, R. J., and El-Defrawy, S. R. (1986). Effects of scopolamine and unilateral lesions of the basal forebrain on T-maze spatial discrimination and alternation in rats.Pharmacology, Biochemistry and Behavior 24: 1353–1360.

    Google Scholar 

  • Bergson, H. (1911).Matter and Memory (Paul, N. M., and Palmer, W. S., trans.), Macmillan, New York.

    Google Scholar 

  • Brown, J., Brown, M. W., and Bowes, J. B. (1983). Effects of lorazepam on rate of forgetting, on retrieval from semantic memory and on manual dexterity.Neuropsychologia 21: 501–512.

    PubMed  Google Scholar 

  • Bures, J. (1979). Spatial working memory: Significance of intramaze and extramaze cues.The Behavioral and Brain Sciences 2: 325.

    Google Scholar 

  • Butters, N., and Albert, M. S. (1982). Processes underlying failures to recall remote events. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 257–274.

    Google Scholar 

  • Butters, N., and Cermak, L. S. (1986). A case study of the forgetting of autobiographical knowledge: Implications for the study of retrograde amnesia. In Rubin, D. (ed.),Autobiographical Memory, Cambridge University Press, Cambridge, pp. 253–272.

    Google Scholar 

  • Butters, N., Granholm, E., Salmon, D. P., Grant, I., and Wolfe, J. (1987). Episodic and semantic memory: A comparison of amnesic and demented patients.Journal of Clinical and Experimental Neuropsychology 9: 479–497.

    PubMed  Google Scholar 

  • Caine, E. D., Weingartner, H., Ludlow, C. L., Cudahy, E. A., and Wehry, S. (1981). Qualitative analysis of scopolamine-induced amnesia.Psychopharmacology 74: 74–80.

    PubMed  Google Scholar 

  • Cermak, L. S. (1984). The episodic/semantic distinction in amnesia. In Squire, L. R., and Butters, N. (eds.),Neuropsychology of Memory, The Guilford Press, New York, pp. 55–62.

    Google Scholar 

  • Cermak, L. S., and O'Connor, M. (1983). The anterograde and retrograde retrieval ability of a patient with amnesia due to encephalitis.Neuropsychologia 21: 213–234.

    PubMed  Google Scholar 

  • Chrobak, J. J., Hanin, I., Schmechel, D. E., and Walsh, T. J. (1988). AF64A-induced working memory impairment: Behavioral, neurochemical and histological correlates.Brain Research 463: 107–117.

    PubMed  Google Scholar 

  • Cohen, N. J., and Squire, L. R. (1981). Retrograde amnesia and remote memory impairment.Neuropsychologia 19: 337–356.

    PubMed  Google Scholar 

  • Damasio, A. R., Eslinger, P. J., Damasio, H., Van Hoesen, G. W., and Cornell, S. (1985). Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage.Archives of Neurology 42: 252–259.

    PubMed  Google Scholar 

  • Davis, H. P., Tribuna, J., Pulsinelli, W. A., and Volpe, B. T. (1986). Reference and working memory of rats following hippocampal damage induced by transient forebrain ischemia.Physiology and Behavior 37: 387–392.

    PubMed  Google Scholar 

  • Davis, K. L., Mohs, R. C., and Tinklenberg, J. R. (1979). Enhancement of memory by physostigmine.New England Journal of Medicine 301: 946.

    Google Scholar 

  • Divac, I. (1979). A neuropsychological theory of hippocampal function: Procrustean treatment of inconvenient data.The Behavioral and Brain Sciences 2: 326–327.

    Google Scholar 

  • Douglas, R. J. (1979). Working memory, interference, and inhibition.The Behavioral and Brain Sciences 2: 327–328.

    Google Scholar 

  • Emerich, D. F., and Walsh, T. J. (1989). Selective working memory impairments following intradentate injection of colchicine: Attenuation of the behavioral but not the neuropathological effects by gangliosides GM1 and AGF2.Physiology and Behavior 45: 93–101.

    PubMed  Google Scholar 

  • Gabrieli, J. D. E., Cohen, N. J., and Corkin S. (1988). The impaired learning of semantic knowledge following bilateral medial temporal-lobe resection.Brain and Cognition 7: 157–177.

    PubMed  Google Scholar 

  • Ghoneim, M. M., Hinrichs, J. V., and Mewaldt, S. P. (1984). Dose-response analysis of the behavioral effects of diazepam: I. Learning and memory.Psychopharmacology 82: 291–295.

    PubMed  Google Scholar 

  • Gold, P. E., and Zornetzer, S. F. (1983). The mnemon and its juices: Neuromodulation of memory processes.Behavioral and Neural Biology 38: 151–189.

    PubMed  Google Scholar 

  • Halgren, E. (1979). The human amnesic syndrome and homologies in cross-species hippocampal function.The Behavioral and Brain Sciences 2: 330–331.

    Google Scholar 

  • Honig, W. K. (1979). Spatial aspects of working memory.The Behavioral and Brain Sciences 2: 332–333.

    Google Scholar 

  • Humphreys, M. S., Bain, J. D., and Pike, R. (1989). Different ways to cue a coherent memory system: A theory for episodic, semantic, and procedural tasks.Psychological Review 96: 208–233.

    Google Scholar 

  • Huppert, F. A., and Piercy, M. (1982). In search of the functional locus of amnesic syndromes. In Cermak, L. S. (ed),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 123–137.

    Google Scholar 

  • Isaacson, R. L., and Bohus, B. (1979). Multiple memories?The Behavioral and Brain Sciences 2: 334.

    Google Scholar 

  • James. W. (1890).The Principles of Psychology, Henry Holt, New York.

    Google Scholar 

  • Jarrard, L. E. (1979). On the role of the hippocampus in memory: Information processing versus memory system.The Behavioral and Brain Sciences 2: 334–335.

    Google Scholar 

  • Jarrard, L. E. (1983). Selective hippocampal lesions and behavior: Effects of kainic acid lesions on performance of place and cue tasks.Behavioral Neuroscience 97: 873–889.

    PubMed  Google Scholar 

  • Jarrard, L. E., Kant, G. J., Meyerhoff, J. L., and Levy, A. (1984a). Behavioral and neurochemical effects of intraventricular AF64A administration in rats.Pharmacology, Biochemistry and Behavior 21: 273–280.

    Google Scholar 

  • Jarrard, L. E., Okaichi, H., Steward, O., and Goldschmidt, R. B. (1984b). On the role of hippocampal connections in the performance of place and cue tasks: Comparisons with damage to hippocampus.Behavioral Neuroscience 6: 946–954.

    Google Scholar 

  • Jucker, M., Oettinger, R., and Battig, K. (1988). Age-related changes in working and reference memory performance and locomotor activity in the Wistar rat.Behavioral and Neural Biology 50: 24–36.

    PubMed  Google Scholar 

  • Kaye, W. H., Sitaram, N., Weingartner, H., Ebert, M. H., Smallberg, S., and Gillin, J. C. (1982). Modest facilitation of memory in dementia with combined lecithin and anticholinesterase treatment.Biological Psychiatry 17: 275–280.

    PubMed  Google Scholar 

  • Kimble, D. P. (1979). Some working notes on working memory.The Behavioral and Brain Sciences 2: 335–336.

    Google Scholar 

  • Kinsbourne, M., and Wood, F. (1975). Short-term memory processes and the amnesic syndrome. In Deutsch, D., and Deutsch, J. A. (eds.),Short-Term Memory, New York: Academic Press.

    Google Scholar 

  • Kinsbourne, M. and Wood, F. (1982). Theoretical considerations regarding the episodic-semantic memory distinction. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 195–217.

    Google Scholar 

  • Kihlstrom, J. F. (1984). A fact is a fact is a fact.The Behavioral and Brain Sciences 7: 243–244.

    Google Scholar 

  • Klatzky, R. L. (1984). Armchair theorists have more fun.The Behavioral and Brain Sciences 7: 244.

    Google Scholar 

  • Knowlton, B. J., Wenk, G. L., Olton, D. S., and Coyle, J. T. (1985). Basal forebrain lesions produce a dissociation of trial-dependent and trial-independent memory performance.Brain Research 345: 315–321.

    PubMed  Google Scholar 

  • Kopelman, M. D. (1989). Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients.Neuropsychologia 27: 437–460.

    PubMed  Google Scholar 

  • Kopelman, M. D., Wilson, B. A., and Baddeley, A. D. (1989). The autobiographical memory interview: A new assessment of autobiographical and personal semantic memory in amnesic patients.Journal of Clinical and Experimental Neuropsychology 11: 724–744.

    PubMed  Google Scholar 

  • Kuhn, T. S. (1970).The Structure of Scientific Revolutions, University of Chicago Press, Chicago.

    Google Scholar 

  • Levy, A., Kluge, P. B., and Elsmore, T. F. (1983). Radial arm maze performance of mice: Acquisition and atropine effects.Behavioral and Neural Biology 39: 229–240.

    PubMed  Google Scholar 

  • Lister, R. G. (1985). The amnesic action of benzodiazepines in man.Neuroscience and Biobehavioral Reviews 9: 87–94.

    PubMed  Google Scholar 

  • Lister, R. G., and File, S. E. (1984). The nature of lorazepam-induced amnesia.Psychopharmacology 83: 183–187.

    PubMed  Google Scholar 

  • Luria, A. R. (1966).Higher Cortical Functions in Man, Tavistock, London.

    Google Scholar 

  • Mahut, H. (1979). Nonunitary function of the hippocampus in the monkey.The Behavioral and Brain Sciences 2: 337–338.

    Google Scholar 

  • McClelland, J. L., Rumelhart, D. E., and the PDP Research Group (1986).Parallel Distributed Processing: Explorations in the Microstructure of Cognition, Vol. 2: Psychological and Biological Models, The MIT Press, Cambridge, MA.

    Google Scholar 

  • McIntyre, J. S., and Craik, F. I. M. (1987). Age differences in memory for item and source information.Canadian Journal of Psychology 41: 175–192.

    PubMed  Google Scholar 

  • McKoon, G., Ratcliff, R., and Dell, G. S. (1986). A critical evaluation of the semantic-episodic distinction.Journal of Experimental. Psychology: Learning, Memory and Cognition 12: 295–306.

    Google Scholar 

  • Murray, C. L., and Fibiger, H. C. (1986). The effect of pramiracetam (CI-879) on the acquisition of a radial arm maze task.Psychopharmacology 89: 378–381.

    PubMed  Google Scholar 

  • Nadel, L. (1979). Working memory won't work.The Behavioral and Brain Sciences 2: 338–339.

    Google Scholar 

  • Nebes, R. D., Martin, D. C., and Horn, L. C. (1984). Sparing of semantic memory in Alzheimer's disease.Journal of Abnormal Psychology 93: 321–330.

    PubMed  Google Scholar 

  • Newman, R. P., Weingartner, H., Smallberg, S., and Calne, D. B. (1984). Effortful and automatic memory processes: Effects of dopamine.Neurology 34: 805–807.

    PubMed  Google Scholar 

  • Nissen, M. J., Knopman, D. S., and Schacter, D. L. (1987). Neurochemical dissociation of memory systems.Neurology 37: 789–794.

    PubMed  Google Scholar 

  • Nonneman, A. J. (1979). Hippocampus, maps, and memory: Toward a rapprochement.The Behavioral and Brain Sciences 2: 339.

    Google Scholar 

  • Okaichi, H., and Jarrard, L. E. (1982). Scopolamine impairs performance of a place and cue task in rats.Behavioral and Neural Biology 35: 319–325.

    PubMed  Google Scholar 

  • O'Keefe, J. (1979). Hippocampal function: Does the working memory hypothesis work? Should we retire the cognitive map theory?The Behavioral and Brain Sciences 2: 339–343.

    Google Scholar 

  • Olton, D. S. (1984). Comparative analysis of episodic memory.The Behavioral and Brain Sciences 7: 250–251.

    Google Scholar 

  • Olton, D. S., and Papas, B. C. (1979). Spatial memory and hippocampal function.Neuropsychologia 17: 669–682.

    PubMed  Google Scholar 

  • Olton, D. S., Becker, J. T., and Handelmann, G. E. (1979). Hippocampus, space, and memory.The Behavioral and Brain Sciences 2: 313–365.

    Google Scholar 

  • Ostergaard, A. L. (1987). Episodic, semantic and procedural memory in a case of amnesia at an early age.Neuropsychologia 25: 341–357.

    PubMed  Google Scholar 

  • Parkin, A. J. (1982). Residual learning capability in organic amnesia.Cortex 18: 417–440.

    PubMed  Google Scholar 

  • Rauch, S. L., and Raskin, L. A. (1984). Cholinergic mediation of spatial memory in the pre-weanling rat: Application of the radial arm maze paradigm.Behavioral Neuroscience 98: 35–43.

    PubMed  Google Scholar 

  • Reiff, R., and Scheerer, M. (1959).Memory and Hypnotic Age Regression, International Universities Press, New York.

    Google Scholar 

  • Roediger, H. L., III (1984). Does current evidence from dissociation experiments favor the episodic/semantic distinction?The Behavioral and Brain Sciences 7: 252–254.

    Google Scholar 

  • Rumelhart, D. E., McClelland, J. L., and the PDP Research Group (1986).Parallel Distributed Processing: Explorations in the Microstructure of Cognition, Vol. 1: Foundations, The MIT Press, Cambridge, MA.

    Google Scholar 

  • Schacter, D. L. (1983). Amnesia observed: Remembering and forgetting in a natural environment.Journal of Abnormal Psychology 92: 236–242.

    PubMed  Google Scholar 

  • Schacter, D. L., and Tulving, E. (1982). Memory, amnesia, and the episodic/semantic distinction. In Isaacson, R. L., and Spear, N. E. (eds.),The Expression of Knowledge: Neurobehavioral Transformations of Information into Action, Plenum Press, New York, pp. 33–65.

    Google Scholar 

  • Schacter, D. L., Harbluk, J. L., and McLachlan, D. R. (1984). Retrieval without recollection: An experimental analysis of source amnesia.Journal of Verbal Learning and Verbal Behavior 23: 593–611.

    Google Scholar 

  • Shimamura, A. P., and Squire L. R. (1987). A neuropsychological study of fact memory and source amnesia.Journal of Experimental Psychology: Learning, Memory, and Cognition 13: 464–473.

    Google Scholar 

  • Squire, L. R. (1982). The neuropsychology of human memory.Annual Review of Neuroscience 5: 241–273.

    PubMed  Google Scholar 

  • Squire, L. R. (1987).Memory and Brain, Oxford University Press, New York.

    Google Scholar 

  • Squire, L. R., and Cohen, N. J. (1979). Hippocampal lesions: Reconciling the findings in rodents and man.The Behavioral and Brain Sciences 2: 345–346.

    Google Scholar 

  • Squire, L. R., and Cohen, N.J. (1982). Remote memory, retrograde amnesia, and the neuropsychology of memory. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 275–303.

    Google Scholar 

  • Sweeney, J. E., Hohmann, C. F., Moran, T. H., and Coyle, J. T. (1988). A long-acting cholinesterase inhibitor reverses spatial memory deficits in mice.Pharmacology, Biochemistry and Behavior 31: 141–147.

    Google Scholar 

  • Tulving, E. (1972). Episodic and semantic memory. In Tulving, E., and Donaldson, W. (eds.),Organization of memory, Academic Press, New York, pp. 381–403.

    Google Scholar 

  • Tulving, E. (1984). Precis ofElements of Episodic Memory.The Behavioral and Brain Sciences 7: 223–268.

    Google Scholar 

  • Tulving, E. (1985). How many memory systems are there?American Psychologist 40: 385–398.

    Google Scholar 

  • Tulving, E. (1987). Multiple memory systems and consciousness.Human Neurobiology 6: 67–80.

    PubMed  Google Scholar 

  • Tulving, E., Schacter, D. L., McLachlan, D., and Moscovitch, M. (1988). Priming of semantic autobiographical knowledge: A case study of retrograde amnesia.Brain and Cognition 8: 3–20.

    PubMed  Google Scholar 

  • Warrington, E. K. (1975). The selective impairment of semantic memory.Quarterly Journal of Experimental Psychology 27: 635–657.

    PubMed  Google Scholar 

  • Weingartner, H., Grafman, J., Bouttelle, W., Kaye, W., and Martin, P. R. (1983). Forms of memory failure.Science 221: 380–382.

    PubMed  Google Scholar 

  • Wilkins, A., and Moscovitch, M. (1978). Selective impairment of semantic memory after temporal lobectomy.Neuropsychologia 16: 73–79.

    PubMed  Google Scholar 

  • Wilson, B., and Baddeley, A. (1988). Semantic, episodic, and autobiographical memory in a postmeningitic amnesic patient.Brain and Cognition 8: 31–46.

    PubMed  Google Scholar 

  • Wirsching, B. A., Beninger, R. J., Jhamandas, K., Boegman, R. J., and El-Defrawy, S. R. (1984). Differential effects of scopolamine on working and reference memory of rats in the radial maze.Pharmacology, Biochemistry and Behavior 20: 659–662.

    Google Scholar 

  • Wolkowitz, O. M., Tinklenberg, J. R., and Weingartner, H. (1985a). A psychopharmacological perspective of cognitive functions: I. Theoretical overview and methodological considerations.Neuropsychobiology 14: 88–96.

    PubMed  Google Scholar 

  • Wolkowitz, O. M., Tinklenberg, J. R., and Weingartner, H. (1985b). A psychopharmacological perspective of cognitive functions: II. Specific pharmacologic agents.Neuropsychobiology 14: 133–156.

    PubMed  Google Scholar 

  • Wolkowitz, O. M., Weingartner, H., Thompson, K. Pickar, D., Paul, S. M., and Hommer, D. (1987). Diazepam-induced amnesia: A neuropharmacological model of an “organic amnestic syndrome.”American Journal of Psychiatry 144: 25–29.

    PubMed  Google Scholar 

  • Wood, F. B., Brown, I. S., and Felton, R. H. (1989). Long-term follow-up of a childhood amnesic syndrome.Brain and Cognition 10: 76–86.

    PubMed  Google Scholar 

  • Wood, F., Ebert, V., and Kinsbourne, M. (1982). The episodic-semantic memory distinction in memory and amnesia: Clinical and experimental observations. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 167–193.

    Google Scholar 

  • Zola-Morgan, S., Cohen, N. J., and Squire, L. R. (1983). Recall of remote episodic memory in amnesia.Neuropsychologia 21: 487–500.

    PubMed  Google Scholar 

  • Zornetzer, S. F., and Abraham, W. C. (1979). The working memory/reference memory theory of hippocampal function: Darts and laurels.The Behavioral and Brain Sciences 2: 351–352.

    Google Scholar 

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  1. Department of Psychology, Emory University, 30322, Atlanta, Georgia

    Michael David Horner

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An earlier version of this paper was submitted as part of the author's qualifying examination at Emory University.

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Horner, M.D. Psychobiological evidence for the distinction between episodic and semantic memory. Neuropsychol Rev 1, 281–321 (1990). https://doi.org/10.1007/BF01109027

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