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Altered expression of a new antigen of the dermal-epidermal junction (NU-T2 DEJ Ag) in junctional epidermolysis bullosa

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Abstract

NU-T2 antigen (Ag) is a new and recently described antigen of the dermal-epidermal junction, recognized by an anti-CD1b monoclonal antibody denominated NU-T2. We studied NU-T2 Ag expression in junctional epidermolysis bullosa (13 patients) and in other forms of hereditary epidermolysis bullosa (23 patients), comparing the results with nicein expression. In junctional epidermolysis bullosa gravis type no differences were found between the expression of NU-T2 and nicein, both being negative in bullous as well as in non-bullous skin. Interestingly, in mitis type junctional epidermolysis bullosa, NU-T2 Ag was found to be absent or reduced in five of six patients both in lesional and in uncleaved skin. When compared with nicein expression, clearcut differences were found, further suggesting that these two antigens are different. These data confirm that NU-T2 Ag is a novel epitope of the dermal-epidermal junction, probably relevant in dermal-epidermal cohesion, and it could be responsible, together with nicein, 19-DEJ-1 and other adhesion molecules, for the different subtypes of junctional epidermolysis bullosa. Finally, NU-T2 monoclonal antibody is a new relevant tool for the diagnosis, classification, and prenatal diagnosis of junctional epidermolysis bullosa.

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Author notes

  1. Gianluca Tadini

    Present address: I Clinica Dermatologica, Via Pace 9, I-20 122, Milano, Italy

Authors and Affiliations

  1. Center for Inherited Cutaneous Diseases, Institute of Dermatological Sciences, IRCCS Ospedale Maggiore, University of Milan, Milan, Italy

    Gianluca Tadini, Riccardo Cavalli, Stefano Cambiaghi & Emilio Berti

  2. INSERM U346-Dermatopathology Laboratory, Department of Dermatology, Hôpital Herriot, Lyon, France

    Jean Kanitakis & Daniel Schmitt

Authors
  1. Gianluca Tadini
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  2. Jean Kanitakis
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  3. Riccardo Cavalli
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  4. Daniel Schmitt
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  5. Stefano Cambiaghi
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  6. Emilio Berti
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Tadini, G., Kanitakis, J., Cavalli, R. et al. Altered expression of a new antigen of the dermal-epidermal junction (NU-T2 DEJ Ag) in junctional epidermolysis bullosa. Arch Dermatol Res 287, 699–704 (1995). https://doi.org/10.1007/BF01105792

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  • DOI: https://doi.org/10.1007/BF01105792

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