Abstract
Recurrence of haemolytic-uraemic syndrome (HUS) after renal transplantation may occur in both cyclosporin A (CyA) and non-CyA-treated patients, and in patients receiving anti-lymphocyte globulin. We report a case of recurrent HUS in an 8-year-old boy who received Orthoclone (OKT3) combined with prednisolone and azathioprine therapy on receipt of his first cadaveric renal allograft. Despite avoidance of CyA therapy irreversible HUS occurred.
This is a preview of subscription content, log in via an institution to check access.
References
Drummond KIN (1985) Hemolytic uremic syndrome then and now. N Engl J Med 312: 116–118
Campos A, Sibley R, Kim Y, Miller K, Michael AF (1981) The hemolytic uremic syndrome. Kidney Int 14: 23–30
Brown CB, Robson JS, Thomson D, Clarkson AR, Cameron JS, Ogg CS (1973) Haemolytic uraemic syndrome in women taking oral contraceptives. Lancet I: 1479–1481
Davidson P, McCredie D, Fair P, Walker RG, Powell HR (1988) Uraemic syndrome after transplantation. Med J Aust 149: 222–223
Van den Berg-Wolf MG, Kootte AMM, Weening JJ, Paul LC (1988) Recurrent haemolytic uraemic syndrome in a renal transplant recipient and review of the Leiden experience. Transplantation 45: 248–251
Van Buren D, Van Buren CT, Flechner SM, Maddox AM, Verani R, Kahan BD (1985) De novo hemolytic uremic syndrome in renal transplant recipients immunosuppressed with cyclosporine. Surgery 98: 54–62
Hebert D, Sibley RK, Mauer SM (1986) Recurrence of haemolytic uraemic syndrome in renal transplant recipients. Kidney Int 30: S51-S58
Grino JM, Caralps A, Carreras L, Nogues R, Castelao AM, Romero R, Carreras M, Alshina J (1988) Apparent recurrence of haemolytic uraemic syndrome in azathioprine-treated allograft recipients. Nephron 49: 301–304
Springate J, Fildes R, Anthone S, Anthone R, Brentjens J, O'Shea M, Feld L (1988) Recurrent haemolytic syndrome after renal transplantation. Transplant 20: 559–561
Eijgenraam FJ, Donckerwolcke RA, Monnen LAH, Proesmans W, Wolff ED, Van Damme B (1990) Renal transplantation in 20 children with hemolytic-uremic syndrome. Clin Nephrol 33: 87–93
Pillay VKG, Kurtzman NA, Manaligod JR, Jonasson O (1973) Selective thrombocytopenia due to localized microangiopathy of renal allografts. Lancet II: 988–991
Magalhaes RL, Braun WE, Straffon RA, Hoffman GC, Shainoff JR, Osborne G, Deodhar SD (1975) Microangiopathic hemolytic anemia in renal allotransplantation: report of a successfully treated case and review of the literature. Am J Med 58: 862–868
Chavers BM, Wells TG, Burke BA, Mauer SM (1990) De novo hemolytic uremic syndrome following renal transplantation. Pediatr Nephrol 4: 62–64
Bunchman TE, Nevins TE, Mauer SM, Chavers BM (1989) Viral complications of OKT3 monoclonal antibody therapy in children undergoing renal transplantation. Transplant Proc 21: 1761–1762
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goodman, D.J., Walker, R.G., Birchall, I.E. et al. Recurrent haemolytic uraemic syndrome in a transplant recipient on Orthoclone (OKT 3). Pediatr Nephrol 5, 240–241 (1991). https://doi.org/10.1007/BF01095964
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01095964