Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney

Abstract

Infiltrating cells were analysed in renal biopsy tissue obtained from a 15-year-old girl with acute interstitial nephritis and uveitis using monoclonal antibodies specific for mononuclear cell surface markers. The interstitial infiltrates consisted mainly of T cells and monocytes/macrophages. A considerable proportion of the infiltrating cells were identified by a monoclonal antibody against the interleukin-2 receptor, indicating that a majority of those immune cells are activated. This observation documents the participation of cell-mediated immune injury in interstitial nephritis associated with uveitis.

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References

  1. 1.

    Neilson EG, Clayman MD, Kelly CJ (1989) Immunopathogenesis of tubulointerstitial disease. In: Massry SG, Glassock RJ (eds) Textbook of nephrology, vol 1. Williams and Wilkins, Baltimore, pp 578–584

    Google Scholar 

  2. 2.

    Colvin RB, Fang LST (1989) Interstitial nephritis. In: Tisher CC, Brenner BM (eds) Renal pathology with clinical and functional correlations, vol 1. Lippincott, Philadelphia, pp 728–776

    Google Scholar 

  3. 3.

    Dobrin RS, Vernier RL, Fish AJ (1975) Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. Am J Med 59: 325–333

    PubMed  Google Scholar 

  4. 4.

    Yoshioka K, Morimoto Y, Iseki T, Maki S (1986) Characterization of tubular basement membrane antigens in human kidney. J Immunol 136: 1654–1660

    PubMed  Google Scholar 

  5. 5.

    Falk RJ, Dalmasso AP, Kim Y, Tsai C, Scheinman JL, Gewurz H, Michael AF (1983) Neoantigen of the polymerized ninth component of complement: characterization of a monoclonal antibody and immunohistochemical localization in renal disease. J Clin Invest 72: 560–573

    PubMed  Google Scholar 

  6. 6.

    Yoshioka K, Takemura T, Matsubara K, Miyamoto H, Akano N, Maki S (1987) Immunohistochemical studies of reflux nephropathy. The role of extracellular matrix, membrane attack complex, and immune cells in glomerular sclerosis. Am J Pathol 129: 223–231

    PubMed  Google Scholar 

  7. 7.

    Yoshoka K, Takemura T, Aya N, Akano N, Miyamoto H, Maki S (1989) Monocyte infiltration and cross-linked fibrin deposition in IgA nephritis and Henoch-Schoenlein purpura nephritis. Clin Nephrol 32: 107–112

    PubMed  Google Scholar 

  8. 8.

    Platt JL, Lebien TW, Michael AF (1982) Interstitial mononuclear cell populations in renal graft rejection: identification by monoclonal antibodies in tissue sections. J Exp Med 155: 17–30

    PubMed  Google Scholar 

  9. 9.

    Platt JL, Sibley RK, Michael AF (1985) Interstitial nephritis associated with cytomegalovirus infection. Kidney Int 28: 550–552

    PubMed  Google Scholar 

  10. 10.

    Nagata K, Platt JL, Michael AF (1984) Interstitial and glomerular immune cell populations in idiopathic nephrotic syndrome. Kidney Int 25: 88–93

    PubMed  Google Scholar 

  11. 11.

    Smith KA (1988) Interleukin-2: inception, impact, and implications. Science 240: 1169–1176

    PubMed  Google Scholar 

  12. 12.

    Hinglais N, Kazatchkine MD, Charron DJ, Appay M-D, Mandet C, Paing M, Bariety J (1984) Immunohistochemical study of Ia antigen in the normal and diseased human kidney. Kidney Int 25: 544–550

    PubMed  Google Scholar 

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Correspondence to Kazuo Yoshioka.

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Yoshioka, K., Takemura, T., Kanasaki, M. et al. Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney. Pediatr Nephrol 5, 232–234 (1991). https://doi.org/10.1007/BF01095961

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Key words

  • Acute interstitial nephritis
  • Uveitis