Skip to main content
Log in

Prior dialysis does not affect the outcome of pediatric renal transplantation

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

The effect of pretransplantation dialysis treatment was examined retrospectively in 70 children less than 6 years old receiving a primary renal transplant at the University of Minnesota. Patient and graft survivals were compared at 1, 2 and 3 years and there were no significant differences between patients who received only hemodialysis (group 1), only peritoneal dialysis (group 2), or no prior dialysis (group 3). All patients received deliberate blood transfusions before transplantation and children at risk for recurrent diseases were excluded from the analyses. No grafts were lost due to perioperative thrombosis. Also, treatment with cyclosporine A did not significantly influence the outcomes. In this series, the choice to proceed directly to renal transplantation without an interposed interval of dialysis imposes no penalty in terms of patient or graft survival. Likewise, when dialysis was required, the dialysis mode selected exerted no clear effect on the outcome of transplantation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Guillou PJ, Will EJ, Davison AM, Giles GR (1984) CAPD—a risk factor in renal transplantation? Br J Surg 71: 878–880

    PubMed  Google Scholar 

  2. Sekkarie MA, Port FK, Wolfe RA, Guire K, Humphrys R, Van Amburg G, Ferguson CW (1990) Recovery from end-stage renal disease. Am J Kidney Dis 15: 61–65

    PubMed  Google Scholar 

  3. Migliori RJ, Simmons RL, Payne WD, Ascher NL, Sutherland DER, Najarian JS, Fryd D (1987) Renal transplantation done safely without prior chronic dialysis therapy. Transplantation 43: 51–55

    PubMed  Google Scholar 

  4. Fehrman I, Fehrman J, Lundgren G, Moller E, Groth CG (1980) Cadaveric graft survival: the bearing of the number of blood transfusions and dialysis treatment. Scand J Urol Nephrol [Suppl] 54: 49–51

    Google Scholar 

  5. Harmon WE, Stablein D, Alexander SR, Tejani A (1991) Graft thrombosis as a cause of graft failure in pediatric renal transplant recipients. Transplantation (in press)

  6. Broyer M, Gagnadoux M-F, Guest G, Beurton D, Niaudet P, Habib R, Busson M (1987) Kidney transplantation in children: results of 383 grafts performed at Enfants Malades Hospital from 1973–1984. Adv Nephrol 16: 307–334

    Google Scholar 

  7. Tagge EP P, Campbell DA, Dafoe DC, Merion RM, Sedman AB, Kelsch RC, Mollen E, Rocher LL, Turcotte JG (1987) Pediatric renal transplantation with an emphasis on the prognosis of patients with chronic renal insufficiency since infancy. Surgery 102: 692–698

    PubMed  Google Scholar 

  8. Potter D, Feduska N, Melzer J, Garvoy M, Hopper S, Duca R, Salvatierra O (1986) Twenty years of renal transplantation in children. Pediatrics 77: 465–470

    PubMed  Google Scholar 

  9. Chavers BM, Matas AJ, Nevins TE, Mauer SM, Sutherland DER, Payne W, Dunn D, Gillingham K, Najarian JS (1990) Results of pediatric kidney transplantation at the University of Minnesota. In: Terasaki PI (ed) Clinical transplants-1990. UCLA Tissue Typing Laboratory, Los Angeles

    Google Scholar 

  10. Najarian JS, Frey DJ, Matas AJ, Gillingham KJ, So SKS, Cook M, Chavers B, Mauer SM, Nevins TE (1990) Renal transplantation in infants. Ann Surg 212: 353–365

    PubMed  Google Scholar 

  11. Gehan EA (1965) A generalized Wilcoxon test for comparing arbitratily singly censored samples. Biometrika 52: 203–223

    PubMed  Google Scholar 

  12. Ettenger RB, Blifeld C, Prince H, Gradus DB, Cho S, Sekiya N, Salusky IB, Fine R (1987) The pediatric nephrologist's dilemma: growth after renal transplantation and its interaction with age as a possible immunologic variable. J Pediatr 111: 1022–1025

    PubMed  Google Scholar 

  13. Cardella CJ (1980) Renal transplantation in patients on peritoneal dialysis. Perit Dial Bull 1: 12–14

    Google Scholar 

  14. Glass NR, Miller DT, Sollinger HW, Zimmerman SW, Simpson D, Beklzer FO (1985) Renal transplantation in patients on peritoneal dialysis. Perit Dial Bull 5: 157–160

    Google Scholar 

  15. Leichter HE, Salusky IB, Ettenger RB, Jordan SC, Hall TL, Marik J, Fine RN (1986) Experience with renal transplantation in children undergoing peritoneal dialysis (CAPD/CCPD). Am J Kidney Dis 8: 181–185

    PubMed  Google Scholar 

  16. Hymes LC, Warshaw BL (1986) Renal transplantation in children undergoing peritoneal dialysis. Perit Dial Bull 6: 74–76

    Google Scholar 

  17. Malagon M, Hogg RJ (1987) Renal transplantation after prolonged dwell peritoneal dialysis in children. Kidney Int 31: 891–985

    Google Scholar 

  18. Nevins TE (1987) Transplantation in infants less than 1 year of age. Pediatr Nephrol 1: 154–156

    PubMed  Google Scholar 

  19. Stefanidis CJ, Balfe JW, Arbus GS, Hardy BE, Churchill BM, Rance CP (1983) Renal transplantation in children treated with continuous ambulatory peritoneal dialysis. Perit Dial Bull 3: 5–8

    Google Scholar 

  20. Rodby RA, Korbet SM, Lewis EJ (1987) Persistence of clinical and serologic activity in patients with systemic lupus erythematosus undergoing peritoneal dialysis. Am J Med 83: 613–618

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nevins, T.E., Danielson, G. Prior dialysis does not affect the outcome of pediatric renal transplantation. Pediatr Nephrol 5, 211–214 (1991). https://doi.org/10.1007/BF01095954

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01095954

Key words

Navigation