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Fibronectin-immunoglobulin complexes in the early course of IgA and Henoch-Schönlein nephritis

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Abstract

We have previously reported the presence of circulating IgA-fibronectin complexes in adult patients with primary IgA nephropathy. In the present study five children were serially investigated during the early course of IgA nephropathy and Henoch-Schönlein glomerulonephritis. Using affinity chromatography procedures and enzyme-linked immuno-sorbent assay, IgA, IgG and IgM in complex with fibronectin were repeatedly demonstrated during the follow-up period in both groups of patients. Most patients had, at the same time, IgA, IgG, as well as IgM deposits in the glomerular mesangium. The simultaneous presence of IgA and IgG in complexes purified from serum was furthermore demonstrated. The results are thus in contrast to the findings in adults with IgA nephropathy, in whom the immunoglobulin-fibronectin complexes only contained IgA. Whether this reflects different subgroups of patients or a different pathophysiology in children and adults remains to be elucidated.

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References

  1. Clarkson AR (1987) Henoch-Schönlein purpura and IgA nephropathy: to separate or unify? In: Clarkson AR (ed) IgA nephropathy. Nijhoff, Boston, pp 39–46

    Google Scholar 

  2. Le Savre PH, Digeon M, Bach JF (1982) Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48: 61–69

    PubMed  Google Scholar 

  3. Woodroffe AJ, Gormly AA, McKenzie PE, Wotton AM, Thompson AJ, Seymour AE, Clarkson AR (1980) Immunologic studies in IgA nephropathy. Kidney Int 18: 366–374

    PubMed  Google Scholar 

  4. Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G (1982) Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schönlein nephritis. Correlation with clinical and histologic signs of activity. Clin Nephrol 18: 230–239

    PubMed  Google Scholar 

  5. Bergér J, Yaneva H, Nabarra B, Barbanel C (1975) Recurrence of mesangial deposition of IgA after renal transplantation. Kidney Int 7: 232–241

    PubMed  Google Scholar 

  6. Levy M, Moussa RA, Habib R, Gagnadoux MF, Broyer M (1982) Anaphylactoid purpura nephritis and transplantation (abstract). Kidney Int 22: 326

    Google Scholar 

  7. Cederholm B, Wieslander J, Bygren P, Heinegård D (1988) Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy. Proc Natl Acad Sci USA 85: 4865–4868

    PubMed  Google Scholar 

  8. Cederholm B, Bygren P, Wieslander J, Heinegård D (1986) Patients with IgA nephropathy have circulating anti-basement membrane antibodies reacting with structures common to collagen I, II and IV. Proc Natl Acad Sci USA 83: 6151–6155

    PubMed  Google Scholar 

  9. Aperia A, Bergstrand A, Broberger O, Linné T, Wasserman J (1979) Renal functional changes in acute glomerulonephritis in children. A one-year follow-up. Acta Paediatr Scand 68: 173–180

    PubMed  Google Scholar 

  10. Linné T, Aperia A, Broberger O, Bergstrand A, Bohman SO, Rekola S (1982) Course of renal function in IgA glomerulonephritis in children and adolescents. Acta Paediatr Scand 71: 735–743

    PubMed  Google Scholar 

  11. Linné T, Aperia A, Broberger O, Bergstrand A, Bohman SO, Wasserman J (1983) Renal function and biopsy changes during the course of Henoch-Schönlein glomerulonephritis. Acta Paediatr Scand 72: 97–104

    PubMed  Google Scholar 

  12. Vogel K, Paulsson M, Heinegård D (1984) Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon. Biochem J 223: 587–597

    PubMed  Google Scholar 

  13. Wood G, Rucker M, Davis JW, Entwistle R, Anderson B (1980) Interaction of plasma fibronectin with selected cryoglobulins. Clin Exp Immunol 40: 358–364

    PubMed  Google Scholar 

  14. Engvall E, Ruoslahti E, Miller E (1978) Affinity of fibronectin to collagens of different genetic types and to fibrinogen. J Exp Med 147: 1584–1595

    PubMed  Google Scholar 

  15. Sinico RA, Fornasieri A, Oreni N, Benuzzi S, D'Amico G (1986) Polymeric IgA rheumatoid factor in idiopathic IgA mesangial nephropathy (Berger's disease). J Immunol 137: 536–541

    PubMed  Google Scholar 

  16. Rifai A, Small P, Teague P, Ayoub E (1979) Experimental IgA nephropathy. J Exp Med 150: 1161–1173

    PubMed  Google Scholar 

  17. Cosio F, Bakaletz A (1987) Role of fibronectin on the clearance and tissue uptake of antigen and immune complexes in rats. J Clin Invest 80: 1270–1279

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Nephrology, University Hospital of Lund, S-221 85, Lund, Sweden

    Bo Cederholm & Per Bygren

  2. Department of Paediatrics, Karolinska Institute, St. Göran's Hospital, Stockholm, Sweden

    Tommy Linne

  3. Biocarb AB, Lund, Sweden

    Jörgen Wieslander

  4. Department of Physiological Chemistry, University of Lund, Lund, Sweden

    Bo Cederholm & Dick Heinegård

Authors
  1. Bo Cederholm
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  2. Tommy Linne
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  3. Jörgen Wieslander
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  4. Per Bygren
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  5. Dick Heinegård
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Cederholm, B., Linne, T., Wieslander, J. et al. Fibronectin-immunoglobulin complexes in the early course of IgA and Henoch-Schönlein nephritis. Pediatr Nephrol 5, 200–204 (1991). https://doi.org/10.1007/BF01095952

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  • DOI: https://doi.org/10.1007/BF01095952

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