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Therapy with gastrin antibody in the Zollinger-Ellison syndrome

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Abstract

The therapeutic effectiveness of parenterally administered rabbit antigastrin antibody was evaluated in a patient with the Zollinger-Ellison syndrome who had a fasting serum gastrin level of 3020 pg/ml and a basal gastric acid secretion of 48.9 mEq/hr. Control globulin reduced gastric secretion to 32 mEq/hr. Gastrin antibody reduced it further to 8.7 mEq/hr. Betazole hydrochloride which was given 75 min after administration of gastrin antibody stimulated acid secretion to 57.2 mEq/hr. One day later basal acid secretion was uninhibited although some antibody activity was present in the patient's serum. The results suggested that gastrin antibody acutely inhibited basal but not betazole-stimulated secretion.

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Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology, University of Texas Medical Branch, 77550, Galveston, Texas

    William S. Hughes MD, John B. Hughes MD & Stephan E. Ritzmann MD

Authors
  1. William S. Hughes MD
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  2. John B. Hughes MD
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  3. Stephan E. Ritzmann MD
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Additional information

A portion of this paper was presented to the Gastroenterology session of the American Federation for Clinical Research, Southern Section, January 25, 1973.

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Hughes, W.S., Hughes, J.B. & Ritzmann, S.E. Therapy with gastrin antibody in the Zollinger-Ellison syndrome. Digest Dis Sci 21, 201–204 (1976). https://doi.org/10.1007/BF01095891

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  • DOI: https://doi.org/10.1007/BF01095891

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