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Anticholinesterase properties of methyl-(ω-alkoxyalkoxy)-phosphoryloxylupinanes, N-[methyl-(ω-alkoxyalkoxy)-phosphoryloxyethyl]anabasines, and their methiodides

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A study was made of the reaction of acetylcholinesterase and butyrylcholinesterase with some methyl-(ω-alkoxyalkoxy)phosphoryloxylupinanes and N-[methyl-(ω-alkoxyalkoxy)phosphoryloxyethyl]anabasines, and with the corresponding methiodides and dimethiodides.

  2. 2.

    The studied compounds are reversible inhibitors, whose activity depends both on the presence and position of a hydrophilic oxygen atom in the alkoxyl group.

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Literature cited

  1. M. Kh. Bekanov, Dissertation, Moscow (1974).

  2. N. N. Godovikov, A. A. Abduvakhabov, Kh. A. Aslanov, S. A. Auelbekov, M. I. Kabachnik, and A. S. Sadykov, Zh. Obshch. Khim.,44, 687 (1974).

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  3. J. L. Webb, Enzyme and Metabolic Inhibitors, Academic Press (1963).

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Authors and Affiliations

  1. A. N. Nesmeyanov Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, Moscow

    A. A. Abduvakhabov, O. Kh. Kholbekov, S. A. Auelbekov & N. N. Godovikov

  2. Institute of Bioorganic Chemistry of the Academy of Sciences of the Uzbek SSR, Tashkent

    A. A. Abduvakhabov, O. Kh. Kholbekov, S. A. Auelbekov & N. N. Godovikov

Authors
  1. A. A. Abduvakhabov
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  2. O. Kh. Kholbekov
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  3. S. A. Auelbekov
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  4. N. N. Godovikov
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2606–2609, November, 1981.

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Abduvakhabov, A.A., Kholbekov, O.K., Auelbekov, S.A. et al. Anticholinesterase properties of methyl-(ω-alkoxyalkoxy)-phosphoryloxylupinanes, N-[methyl-(ω-alkoxyalkoxy)-phosphoryloxyethyl]anabasines, and their methiodides. Russ Chem Bull 30, 2164–2166 (1981). https://doi.org/10.1007/BF01094649

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  • DOI: https://doi.org/10.1007/BF01094649

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