Abstract
The hypocholesterolemic effect of dietary proteins could not be related to their vegetal or animal origin and seemed correlated to their different amino acids proportions. Comparing rats fed soy protein diet to those fed casein diet for 45 days, we observed a decrease of serum HDL cholesterol levels. Furthermore sequential centrifugation showed a decrease of HDL2–3 fraction and especially apolipoprotein E in the serum of soy protein fed rats. The sodium phytate, added to the diet, did not change the metabolism of sterols.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abell LL, Levy BB, Brodie BB, Kendall FE (1952) A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem 195:357–366
Bazzano G (1969) Hypocholesterolemic effect of glutamic acid in the Mongolian gerbil. Proc Soc Exp Biol Med 131:1463–1465
Carroll KK, Giovanetti PM, Huff MW, Moase O, Roberts DCK, Wolfe BM (1978) Hypocholesterolemic effect of substituting soybean protein for animal protein in the diet of healthy young women. Am J Clin Nutr 31:1312–1321
Czarnecki SK, Kritchevsky D (1979) The effect of dietary proteins on Lipoprotein metabolism and atherosclerosis in rabbits. J Am Oil Chem Soc 56:388 A
Folch J, Lees M, Stanley GHS (1957) A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497–509
Forsythe WA, Miller ER, Hill GM, Romsos DR, Simpson RC (1980) Effects of dietary protein and fat sources on plasma cholesterol parameters, LCAT activity and amino acid levels and on tissue lipid content of growing pigs. J Nutr 110:2467–2479
Grove TH (1979) Effect of reagent PH on determination of high-density lipoprotein cholesterol by precipitation with sodium phosphotungstate-magnesium. Clin Chem 25:560–564
Hodges RE, Krehl WA, Stome DB, Lopez A (1967) Dietary carbohydrates and low cholesterol diets: effects on serum lipids. Am J Clin Nutr 20:198–208
Huff MW, Carroll KK (1980) Effects of dietary proteins and amino acid mixtures on plasma cholesterol levels in rabbits. J Nutr 110:1676–1685
Katan MB, Vroomen L, Hermus RJ (1980) Reduction of casein-induced hypercholesterolemia and atherosclerosis in rabbits and rats by dietary glycine. VII International Symposium on Drugs Affecting Lipid Metabolism, Milan
Klevay LM (1977) Hypocholesterolemia due to sodium phytate. Nutr Reports Intern 15:587–595
Nagata Y, Tanaka K, Sugano M (1981) Further studies on the hypocholesterolemic effect of soya-bean protein in rats. Br J Nutr 45:233–241
Roberts DCK, Huff MW, Caroll KK (1979) Plasma lipoprotein changes in suckling and weanling rabbits fed semi-purified diets. Lipids 14:566–571
Röschlau P Von, Bernt E, Gruber W (1974) Enzymatische Bestimmung des gesamt Cholesteryls in Serum. Z Klin Chem Klin Biochem 12:226
Sautier C, Doucet C, Flament C, Lemonnier D (1979) Effects of soy protein and saponins on serum, tissue and feces steroids in rat. Atherosclerosis 34:233–241
Sirtori CR, Agradi E, Conti F, Mantero O, Gatti E (1977) Soybean protein diet in the treatment of type II hyperlipoproteinaemia. Lancet I:275–277
Weber A (1972) The quantitative determination of fecal bile acids in children by the enzymatic method. Clin Chim Acta 39:524–531
Weber K, Osborn M (1969) The reliability of molecular weight determination of dodecylsulfate-polyacrylamide gel electrophoresis. J Biol Chem 224:4406–4412
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Sautier, C., Dieng, K., Flament, C. et al. The influence of four dietary proteins and sodium phytate on the metabolism of cholesterol and the lipoproteins in rat. Plant Food Hum Nutr 33, 193–199 (1983). https://doi.org/10.1007/BF01091308
Issue Date:
DOI: https://doi.org/10.1007/BF01091308