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Reduced plasma fibrinogen, serum peroxides, lipids, and apolipoproteins after a 3-week vegetarian diet

Abstract

The influence of a 3-week vegetarian diet and fasting on serum concentration of peroxides, lipids, apolipoproteins, and plasma fibrinogen was studied in ten middle-aged fibromyalgia/fibrositis patients (eight women, two men). Mean serum peroxide concentration (estimated as thiobarbituric acid reacting substances) was reduced from 3.60±0.14 to 2.82±0.15 umol/l (p=0.01) and plasma fibrinogen from 3.33±0.25 to 2.74±0.15 g/l (p=0.02). Serum total cholesterol fell from 6.61±0.50 to 4.83±0.35 mmol/l (p<0.0001), apolipoprotein B from 1.77±0.14 to 1.31±0.11 g/l (p<0.0001), and apolipoprotein A from 1.41±0.09 to 1.23±0.05 g/l (p=0.03). High density lipoprotein cholesterol concentration also decreased somewhat (from 1.26±0.09 to 1.07±0.04 mmol/l,p=0.03) An atherogenic index, reflecting the balance between low and high density lipoproteins, was reduced by 31% (from 5.74±0.79 to 3.97±0.60,p=0.02). The results suggest that vegetarian diet/fasting may have a beneficial influence on the concentration of serum peroxides and plasma fibrinogen concentration, and on the serum level of several lipoprotein-related coronary risk factors.

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References

  1. Kannel WB, Wolf PA, Castelli WP, D'Agostino RB (1987) Fibrinogen and risk of cardiovascular disease. The Framingham study. JAMA 258: 1183–1186

    Google Scholar 

  2. Høstmark AT, Bjerkedal T, Kierulf P, Flaten H. Ulshagen K (1988) Fish oil and plasma fibrinogen. B Med J 297: 180–181

    Google Scholar 

  3. Haglund O, Luostarinen R, Wallin R, Wibell L, Saldeen T (1991) The effects of fish oil on triglycerides, cholesterol, fibrinogen and malondialdehyde in humans supplemented with vitamin E J Nutr 121: 165–169

    Google Scholar 

  4. Stringer MD, Gørøg PG, Freeman A, and Kakkar VV (1989) Lipid peroxides and atherosclerosis. B med J 298: 281–284

    Google Scholar 

  5. Hubel CA, Roberts JM, Taylor RN, Musci TJ, Rogers GM, McLaughlin MK (1989) Lipid peroxidation in pregnancy: New perspectives on preeclampsia. Am J Obstet Gynecol 161: 1025–1034

    Google Scholar 

  6. Høstmark AT, Osland A, Simonsen S, Levorstad K (1990) Lipoprotein-related coronary risk factors in patients with angiographically defined coronary artery disease: relation to number of stenosed arteries. J Int Med 228: 317–321

    Google Scholar 

  7. Kosugi H, Kojima T, Kikugawa K (1989) Thiobarbituric acid-reactive substances from peroxidized lipids. Lipids 24: 873–881

    Google Scholar 

  8. Clauss A (1957) Gerinnerungsphysiologische Schnellmetode zur Bestimmung des Fibrinogens. Acta Haematol (Basel) 17: 237–246

    Google Scholar 

  9. Høstmark AT (1982) Physical activity and plasma lipids. Scand J Soc Med (Suppl) 29: 83–91

    Google Scholar 

  10. Paffenbarger RS, Hyde RT (1984) Exercise in prevention of coronary heart disease. Prev. Med 13: 3–22

    Google Scholar 

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Høstmark, A.T., Lystad, E., Vellar, O.D. et al. Reduced plasma fibrinogen, serum peroxides, lipids, and apolipoproteins after a 3-week vegetarian diet. Plant Food Hum Nutr 43, 55–61 (1993). https://doi.org/10.1007/BF01088096

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  • DOI: https://doi.org/10.1007/BF01088096

Key words

  • peroxides
  • fibrinogen
  • lipids
  • apolipoproteins
  • vegetarian diet
  • fibromyalgia patients