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Improved stability of the continuous production of acetone-butanol by Clostridium acetobutylicum in a two-stage process

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Abstract

A stable continuous culture has been maintained for 30 days at a high 20 g/l solvent concentration. This substantial increase in the stability of the continuous culture ofClostridium acetobutylicum at the maximal solvent level was achieved by using a two-stage process with a dilution rate of 0.1 h−1 in the first fermentor and 0.04 h−1 in the second fermentor. The two-stage continuous fermentation allows an optimal growth of cells and induction of solvent metabolism in the first stage, and a maximal production yield of solvents in the second stage.

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Authors and Affiliations

  1. Laboratoire des Sciences du Génie Chimique, CNRS-ENSIC-ENSAIA Institut National Polytechnique de Lorraine, 1, rue Grandville, 52042, Nancy Cedex, France

    C. Godin & J. M. Engasser

Authors
  1. C. Godin
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  2. J. M. Engasser
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Godin, C., Engasser, J.M. Improved stability of the continuous production of acetone-butanol by Clostridium acetobutylicum in a two-stage process. Biotechnol Lett 10, 389–392 (1988). https://doi.org/10.1007/BF01087434

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  • DOI: https://doi.org/10.1007/BF01087434

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