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Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog

The American Journal of Digestive Diseases volume 23, pages 781–788 (1978)Cite this article

Abstract

The interaction between motilin and somatostatin on gastrointestinal motor activity was studied in fasted, unanesthetized dogs. Contractions of the stomach, duodenum, jejunum, and ileum were recorded with extraluminal strain gage force transducers. Motilin initiated a pattern of contractile activity which closely resembled phase III of the interdigestive motor complex. Somatostatin delayed the onset of the motilin response and reduced motor activity in the stomach and the jejunum. During somatstatin infusion the motilin-induced contractile pattern did not migrate to the jejunum. The cycle of natural interdigestive motor complexes was also interrupted by somatostatin. Somatostatin alters natural and motilin-induced interdigestive migrating motor complexes of the canine gastrointestinal tract.

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References

  1. Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch EF: Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol 11(Suppl 39):93–110, 1976

    PubMed  Google Scholar 

  2. Wingate DL, Ruppin H, Green WER, Thompson HH, Domschke W, Wunsch E, Demling L, Ritchie HD: Motilin-induced electrical activity in the canine gastrointestinal tract. Scand J Gastroenterol 11(Suppl 39):111–118, 1976

    Google Scholar 

  3. Bloom SR, Mortimer CH, Thorner MO, Besser GM, Hall R, Gomez-Pan A, Roy VM, Russell RCG, Coy DH, Kastin AJ, Schally AV: Inhibition of gastrin and gastric acid secretion by growth hormone release inhibiting hormone. Lancet 2:1106–1109, 1974

    PubMed  Google Scholar 

  4. Konturek SJ, Tasler J, Obtulowicz W, Coy DH, Schally AV: Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion. J Clin Invest 58:1–6, 1976

    PubMed  Google Scholar 

  5. Mitznegg P, Bloom SR, Domschke W, Domschke S, Wunsch E, Demling L: Pharmacokinetics of motilin in man. Gastroenterology 72:413–416, 1977

    PubMed  Google Scholar 

  6. Ito S, Yamada Y, Kobayashi S: Immunohistochemical demonstration of somatostatin-positive cells in the canine gut. Tohoku J Exp Med 121:85–90, 1977

    PubMed  Google Scholar 

  7. Dubois PM, Paulin C, Dubois MP: Gastrointestinal somatostatin cells in the human fetus. Cell Tissue Res 166:179–184, 1976

    PubMed  Google Scholar 

  8. Polak JM, Pearse AGE, Heath CM: Complete identification of endocrine cells in the gastrointestinal tract using semi-thin sections to identify motilin cells in human and animal intestine. Gut 16:225–229, 1975

    PubMed  Google Scholar 

  9. Bass P, Wiley JN: Contractile force transducer for recording muscle activity in unanesthetized animals. J Appl Physiol 32:567–570, 1972

    PubMed  Google Scholar 

  10. Szurszewski JH: A migrating electric complex of the canine small intestine. Am J Physiol 217:1757–1763, 1969

    PubMed  Google Scholar 

  11. Carlson GM, Bedi BS, Code CF: Mechanism of propagation of intestinal interdigestive myoelectric complex. Am J Physiol 222:1027–1030, 1972

    PubMed  Google Scholar 

  12. Code CF, Marlett JA: The interdigestive myo-electric complex of the stomach and small bowel of dogs. J Physiol 246:289–309, 1975

    PubMed  Google Scholar 

  13. Carlson GM, Ruddon RW, Hug CC, Bass P: Effects of nicotine on gastric antral and duodenal contractile activity in the dog. J Pharmacol Exp Ther 172:367–376, 1970

    PubMed  Google Scholar 

  14. Ormsbee HS III, Bass P: Gastroduodenal motor gradients in the dog after pyloroplasty. Am J Physiol 230:389–397, 1976

    PubMed  Google Scholar 

  15. Itoh Z, Aizawa I, Takeuchi S, Couch EF: Hunger contractions and motilin. Proceedings of the 5th International Symposium on Gastrointestinal Motility, Herentals, Belgium. G Vantrappen (ed.). Typoff Press, 1976, pp 48–55

  16. Marik F, Code CF: Control of the interdigestive myoelectric activity in dogs by the vagus nerves and pentagastrin. Gastroenterology 69:387–395, 1975

    PubMed  Google Scholar 

  17. Weisbrodt NW, Copeland EM, Moore EP, Kearley RW, Johnson LR: Effect of vagotomy on electrical activity of the small intestine of the dog. Am J Physiol 228:650–654, 1975

    PubMed  Google Scholar 

  18. Weisbrodt NW, Copeland EM, Kearley RW, Moore EP, Johnson LR: Effects of pentagastrin on electrical activity of small intestine of the dog. Am J Physiol 227:425–429, 1974

    PubMed  Google Scholar 

  19. Ormsbee HS, III, Mir SS: The role of the cholinergic nervous system in the gastrointestinal response to motilinin vivo. Gastrointestinal Motility in Health and Disease. Proceedings of the 6th International Symposium on Gastrointestinal Motility, Lancaster, England. HL Duthie (ed.). MTP Press Ltd, 1978 pp. 113–124

  20. Guillemin R: Somatostatin inhibits the release of acetylcholine induced electrically in the myenteric plexus. Endocrinology 99:1653–1654, 1976

    PubMed  Google Scholar 

  21. Strunz U, Domschke W, Mitznegg P, Domschke S, Schubert E, Wunsch E, Jaeger E, Demling L: Analysis of the motor effects of 13-norleucine motilin on the rabbit, guinea pig, rat, and human alimentary tractin vitro. Gastroenterology 68:1485–1491, 1975

    PubMed  Google Scholar 

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Affiliations

  1. Assistant Professor of Surgery, Department of Surgery, University of Maryland, School of Medicine, 22 South Greene Street, Box 85, 21201, Baltimore, Maryland

    Herbert S. Ormsbee III PhD, Stewart L. Koehler Jr MD & Gordon L. Telford MD

Authors
  1. Herbert S. Ormsbee III PhD
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  2. Stewart L. Koehler Jr MD
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  3. Gordon L. Telford MD
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Supported by a grant from the Bressler Research Fund, University of Maryland, School of Medicine.

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Ormsbee, H.S., Koehler, S.L. & Telford, G.L. Somatostatin inhibits motilin-induced interdigestive contractile activity in the dog. Digest Dis Sci 23, 781–788 (1978). https://doi.org/10.1007/BF01079786

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  • DOI: https://doi.org/10.1007/BF01079786

Keywords

  • Gastrointestinal Tract
  • Motor Activity
  • Strain Gage
  • Contractile Activity
  • Force Transducer