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Functional and genetic analysis of annexin VI

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Abstract

This study is concerned with the determination of the function of the 68kDa calcium-binding protein, annexin VI. Studies on the structure and regulation of the gene include a detailed analysis of annexin VI expressed heterologously in human A431 carcinoma cells. We have recently discovered that annexin VI is subject to a novel growth dependent post-translational modification. Interestingly, the protein exerts a negative effect on A431 cells. This effect was manifested as a partial reversal of the transformed phenotype. We are currently exploring the hypothesis that the post-translational modification of annexin VI is required for sub-cellular targeting, and that correct localisation within the cell is essential for function.

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  1. Department of Physiology, University College London, Gower Street, WC1E 6BT, London, UK

    Helena C. Edwards & Stephen E. Moss

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  1. Helena C. Edwards
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Edwards, H.C., Moss, S.E. Functional and genetic analysis of annexin VI. Mol Cell Biochem 149, 293–299 (1995). https://doi.org/10.1007/BF01076591

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