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Protein tyrosine phosphorylation in cardiovascular system

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Abstract

Protein tyrosine phosphorylation is believed to play a central role in signaling pathways initiated by growth factor receptor activation. Recent studies have shown that various vasoactive peptides, in addition to eliciting a contractile response, also serve as growth factors for vascular smooth muscle and stimulate tyrosyl phosphorylation of several endogenous proteins. Some of these proteins have been identified and are similar to those stimulated by growth factor receptor activation. Furthermore, evidence is also accumulating to support an involvement of protein tyrosine phosphorylation, in acute action of groth factors and vasoactive peptides on smooth muscle contractility. This review will briefly summarize the recent work on vasoactive peptide-mediated protein tyrosine phosphorylation in cardiovascular tissues and its potential functional significance.

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Abbreviations

AII:

angiotensin II

AVP:

arginine vasopressin

DAG:

diacyl glycerol

EGF:

epidermal growth factor

EIF-4:

eukaryotic protein synthesis initiation factor-4

ERK:

extracellar signal regulated kinase

ET-1:

endothelin-1

FAK:

focal adhesion kinase

G-proteins:

guanyl nucleotide binding proteins

GRB-2:

growth factor receptor bound protein-2

IGF-1:

insulin-like growth factor-1

IP3 :

inositol 1,4,5 trisphosphate

IRS-1:

insulin receptor substrate-1

MAPK:

mitogenactivated protein kinase ERK, extracellular signal regulated kinase

MAPKK:

mitogen activated protein kinase kinase; also known as MEK, MAPK or, ERK kinase

PDGF:

platelet derived growth factor

PHAS-I:

phosphorylated heat and acid stable protein regulated by insulin

PKC:

protein kinase C

PLC:

phospholipase C

PMA:

phorobol-12-myristate acetate

PTK:

protein tyrosine kinase

PTPase:

protein tyrosine phosphatese

rsk:

ribosomal S6 kinases

shc:

src homology domain containing protein

SHR:

spontaneously hypertensive rat

SOS:

son of sevenless

WKY:

wistar kyoto

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  1. Research Group on Diabetes and Metabolic Regulation, Centre de Recherche/Hôtel-Dieu de Montréal Hospital, 3850 Saint-Urbain Street, H2W 1T8, Montréal, Québec, Canada

    Ashok K. Srivastava

  2. Department of Medicine, University of Montréal, H2W 1T8, Montréal, Québec, Canada

    Ashok K. Srivastava

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Srivastava, A.K. Protein tyrosine phosphorylation in cardiovascular system. Mol Cell Biochem 149, 87–94 (1995). https://doi.org/10.1007/BF01076567

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