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Significance of cytoplasmic fatty acid-binding protein for the ischemic heart

  • Cellular Fatty Acid-Binding Proteins II
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Abstract

Ischemia of the heart is accompanied by the tissue accumulation of long-chain fatty acids and their metabolic derivatives such as β-hydroxy fatty acids and fatty acyl-CoA and acyl-L-carnitine esters. These substances might be detrimental for proper myocardial function. Previously, it has been suggested that intracellular lipid binding proteins like cytoplasmic fatty acid-binding protein (FABP) and acyl-CoA binding protein (ACBP) may bind these accumulating fatty acyl moieties to prevent their elevated levels from potentially harmful actions. In addition, the suggestion has been made that the abundantly present FABP may scavenge free radicals which are generated during reperfusion of the ischemic heart. However, these protective actions are challenged by the continuous physico-chemical partition of fatty acyl moieties between FABP and membrane structures and by the rapid release of FABP from ischemic and reperfused cardiac muscle. Careful evaluation of the available literature data reveals that at present no definite conclusion can be drawn about the potential protective effect of FABP on the ischemic and reperfused heart. Biochem123: 167–173, 1993)

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Abbreviations

FABP:

Fatty Acid-Binding Protein

ACBP:

Acyl-CoA Binding Protein

MDGI:

Mammary-Derived Growth Inhibitor

CK:

Creatine Kinase

LDH:

Lactate Dehydrogenase

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Authors and Affiliations

  1. Department of Physiology, Cardiovascular Research Institute Maastricht (CARIM), University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands

    Jan F. C. Glatz, Michaël M. Vork & Ger J. van der Vusse

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  1. Jan F. C. Glatz
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  2. Michaël M. Vork
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  3. Ger J. van der Vusse
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Glatz, J.F.C., Vork, M.M. & van der Vusse, G.J. Significance of cytoplasmic fatty acid-binding protein for the ischemic heart. Mol Cell Biochem 123, 167–173 (1993). https://doi.org/10.1007/BF01076489

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