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Potential inhibitors of colon carcinogenesis

  • National Large-Bowel Cancer Project — First Workshop on Large-Bowel Cancer (Part I)
  • Workshop in Colon Cancer—Plenary Session Paper
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

This paper deals with two categories of inhibitory processes which diminish the neoplastic effects of chemical carcinogens on the host. The first involves a group of antioxidants. Intake of these compounds by the host will inhibit the neoplastic response to a substantial variety of chemical carcinogens. Included are BHA and BHT, two antioxidants extensively used as food additives. The second relates to the microsomal mixed-function oxidase system. Induction of increased activity of this system protects against a diverse group of chemical carcinogens. The nature and quantity of diet consumed are of considerable importance in determing the activity of at least certain reactions of the mixed-function oxidase system metabolizing chemical carcinogens in the small intestine. In terms of interpreting epidemiological data, as well as in determining elements in the environment of benefit to the host, it is important to take into account inhibitors and inhibitory systems of chemical carcinogenesis.

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, 55455, Minneapolis, Minnesota

    Lee W. Wattenberg MD

Authors
  1. Lee W. Wattenberg MD
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Additional information

This work was supported by US Public Health Service Grant CA 15638 from The National Cancer Institute.

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Wattenberg, L.W. Potential inhibitors of colon carcinogenesis. Digest Dis Sci 19, 947–953 (1974). https://doi.org/10.1007/BF01076221

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  • DOI: https://doi.org/10.1007/BF01076221

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