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Levels of superoxide dismutase mRNA in rat lens: Effect of aging

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Abstract

Superoxide dismutase, the enzyme catalyzing the dismutation of O2 •− to H2O2 is known to be present in various ocular and nonocular tissues. In this communication we have determined the gene expression of this enzyme in rat lenses. The investigations have been conducted as a function of age using RNase protection assay. Thesein vitro assays for the corresponding mRNA suggested that the transcription of the gene is age variant, increasing as a function of age. The levels were significantly lower in the young lenses in comparison to the older lenses. (Mol Cell Biochem152: 175–178, 1995)

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Authors and Affiliations

  1. Department of Ophthalmology, University of Maryland at Baltimore, 10 S. Pine Street, 21201, Baltimore, MD, USA

    P. S. Devamanoharan, R. Farrell & S. D. Varma

Authors
  1. P. S. Devamanoharan
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  2. R. Farrell
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  3. S. D. Varma
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Devamanoharan, P.S., Farrell, R. & Varma, S.D. Levels of superoxide dismutase mRNA in rat lens: Effect of aging. Mol Cell Biochem 152, 175–178 (1995). https://doi.org/10.1007/BF01076080

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  • DOI: https://doi.org/10.1007/BF01076080

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