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Membrane—vanadium interaction: A toxicokinetic evaluation

  • Part II: Biochemical and Physiological Studies
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Abstract

Vanadium is an important trace metal widely distributed in environment. Interaction of vanadate with skeletal muscle sarcolemma and basement membrane has been focussed. Scatchard analysis indicated the presence of more than one binding site for vanadate. Vanadate inhibits sarcolemmal and intestinal brush border membrane enzymes in a non-competitive manner. Membrane-vanadium interaction may lead to several structural and functional changes. The binding of vanadium to basement membrane may have some protective role.

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Authors and Affiliations

  1. Biomembrane Division, Industrial Toxicology Research Centre, M.G. Marg, Post Box No. 80, 226 001, Lucknow, India

    Raj K. Upreti

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  1. Raj K. Upreti
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Upreti, R.K. Membrane—vanadium interaction: A toxicokinetic evaluation. Mol Cell Biochem 153, 167–171 (1995). https://doi.org/10.1007/BF01075934

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  • DOI: https://doi.org/10.1007/BF01075934

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