Abstract
An electron microscopic investigation was undertaken on adult fasted ferrets in order to clarify the acute gastric mucosal, morphologic response to orally ingested acetylsalicylic acid. A single, clinically relevant dose (10 mg/kg) was administered and gastric surface responses were studied by scanning electron microscopy, and differential early, cytologic responses of the glandular cells were evaluated by transmission electron microscopy. Gastric bleeding was derived from minute, surface erosions morphologically indistinct from stress-type erosions. Parietal cells underwent drug-specific changes and chief cells, nonspecific degenerative changes. Mucous epithelial cells were disrupted only in localized regions, and tight junctions between surface epithelial cells remained intact. The order of decreasing cellular sensitivity to this acute (10–45 min) exposure to HCl-acidified aspirin solution was: parietal cells, chief cells, and surface epithelial cells. Argentaffin cells and mucous neck cells were resistant.
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This study was supported in part by the William H. Rorer Gastroenterology Research Fund.
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Pfeiffer, C.J., Weibel, J. The gastric mucosal response to acetylsalicylic acid in the ferret. Digest Dis Sci 18, 834–846 (1973). https://doi.org/10.1007/BF01073333
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DOI: https://doi.org/10.1007/BF01073333