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Albinism and auditory function in the laboratory mouse. II. Effects of acoustic priming and cross-fostering

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Abstract

Albino (c/c) and nonalbino (+/c and +/+) congenic C57BL/6J mice were examined for the effects of acoustic prestimulation (priming) on audiogenic seizures. While no genotypic-specific effects were noticed 1 day after priming, major effects were observed in separate groups of mice tested 5 days after priming. The c/c mice were most susceptible to audiogenic seizures, and no differences were observed between +/c and +/+ mice. While cross-fostering did not change this relationship, it provided protection for mice of all three genotypes. The interpretation that melanin offers protection from acoustic trauma is considered inconclusive because of the interaction of innate- and priming-induced audiogenic seizures in the +/c and c/c mice.

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Authors and Affiliations

  1. Department of Psychology, University of California, Davis, California

    Mark M. Haythorn & Kenneth R. Henry

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  1. Mark M. Haythorn
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  2. Kenneth R. Henry
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Supported by NSF Grant GB31921 and PHS Grant NS11565-01 to the second author

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Haythorn, M.M., Henry, K.R. Albinism and auditory function in the laboratory mouse. II. Effects of acoustic priming and cross-fostering. Behav Genet 5, 321–329 (1975). https://doi.org/10.1007/BF01073202

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  • DOI: https://doi.org/10.1007/BF01073202

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