Abstract
Infusion of a test solution of gelatin into the proximal jejunum of 5 patients with Billroth II anastomoses with no suspected pancreatic disease produced a mean hydrolysis of 46.2%±4.9 SD of the infused gelatin to dialyzable peptides. In 3 patients with Billroth II anastomoses and chronic pancreatitis, the mean hydrolysis was 16%±2.6 SD. In 5 normal subjects and 7 patients with chronic pancreatitis and no prior surgery, the mean intraduodenal gelatin hydrolysis was 72.4%±9.1 SD and 9.0%±3.6 SD, respectively. These preliminary studies indicate that the gelatin infusion test may be of value in assessing pancreatic function in patients with Billroth II anastomoses in whom a secretin test cannot be performed.
Similar content being viewed by others
References
Cerda JJ, Brooks FP, Prockop DJ: Intraduodenal hydrolysis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes. Gastroenterology 54:358–365, 1968
Kivirikko KI, Laitinen O, Prockop DJ: Modifications of a specific assay for hydroxyproline in urine. Anal Biochem 19:249–255, 1967
Kiekens R, Lundh G: Intestinal digestion and absorption after Billroth II gastrectomy. Acta Chim Scand 113:349–356, 1957
Everson TC: Experimental comparison of protein and fat assimilation after Billroth I, Billroth II, and segmental type of subtotal gastrectomy. Surgery 36:525–537, 1954
Author information
Authors and Affiliations
Additional information
This study was supported in part by Training Grant TI-AM-5462-04 from the National Institutes of Health and a Clinical Investigator Award, Veterans Administration, Washington, DC.
Rights and permissions
About this article
Cite this article
Toskes, P.P., Cerda, J.J. The value of the gelatin infusion test in the diagnosis of pancreatic exocrine insufficiency in patients with Billroth II anastomoses. Digest Dis Sci 18, 147–150 (1973). https://doi.org/10.1007/BF01073160
Issue Date:
DOI: https://doi.org/10.1007/BF01073160