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Studies on iron absorption

II. Transport mechanism of low molecular iron chelate in rat intestine

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Abstract

The mechanism of iron absorption was studied using ligated intestinal loops of rats. Low molecular iron chelate, stable at neutral pH, was used to prevent factors such as the physicochemical properties of iron salts from influencing intestinal absorption of iron. Mucosal uptake of radioiron ceased within 1 hour of the iron injection into jejunum, while net transport of iron from lumen to, carcass proceeded in proportion to time. Total iron absorption by duodenum jejunum, ileum, and rectum measured 8.2, 6.0, 5.0, and 5.1, while net transport of iron to carcass was 6.0, 1.2, 0.7, and 2.3 %/cm of intestinal length in 2 hours. Net transport of iron to carcass via duodenum was higher than via other intestinal segments. The amount of mucosal uptake and the net transport of iron from lumen to carcass increased proportionally depending on the amount of iron injected into duodenum and jejunum in the range of 20 to 1000 μg. Cycloheximide significantly inhibited the mucosal uptake of iron, but had no effect on the net transport of iron from lumen to carcass by duodenum and jejunum.

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Authors and Affiliations

  1. Eisai Research Laboratories 4 Koishikawa, Bunkyo-ku, Tokyo

    Kuniaki Terato BS, Yoshiko Hiramatsu BS &  Yoshio Yoshino MD

  2. Department of Nutrition, Nippon Medical School, Sendagi, Bunkyo-ku, 113, Tokyo, Japan

    Kuniaki Terato BS, Yoshiko Hiramatsu BS &  Yoshio Yoshino MD

Authors
  1. Kuniaki Terato BS
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  2. Yoshiko Hiramatsu BS
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  3. Yoshio Yoshino MD
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Terato, K., Hiramatsu, Y. & Yoshino, Y. Studies on iron absorption. Digest Dis Sci 18, 129–134 (1973). https://doi.org/10.1007/BF01073156

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