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Intrinsic factor secretion in the gastric juice in diabetes mellitus

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Abstract

The secretion of intrinsic factor (IF) in the gastric juice was studied in the basal and maximally stimulated gastric secretion of 40 insulin-dependent, unselected diabetic patients and 28 normal control subjects matched for age and sex. The pattern of IF secretion was studied in relation to a) the presence of intrinsic factor antibodies and parietal cell antibodies in the serum and b) the pattern of gastric secretion with respect to volume, pH, and amount of hydrochloric acid. It has been shown that the incidence of IF deficiency is significantly higher in diabetic patients than in normal control subjects. Impaired secretion of IF is more pronounced in the basal than in the maximally stimulated secretion in diabetic patients. Deficiency of IF among diabetics is often, but not always, associated with circulating IF antibodies in the serum. It is suggested that impaired IF secretion resulting from atrophic gastritis in diabetes mellitus might not necessarily be associated with autoimmunity against IF.

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Authors and Affiliations

  1. Professorial Medical Unit of the Evangelismos Hospital, 35 Homirou Street, T. 135, Athens, Greece

    T. Kanaghinis MD (Assistant Professor of Medicine), N. Iatromanolakis MD, D. Ikkos MD, P. Gatsou BSc & C. Gardikas MD, PhD

  2. Radioisotope Laboratory of the Evangelismos Hospital, 35 Homirou Street, T. 135, Athens, Greece

    T. Kanaghinis MD (Assistant Professor of Medicine), N. Iatromanolakis MD, D. Ikkos MD, P. Gatsou BSc & C. Gardikas MD, PhD

Authors
  1. T. Kanaghinis MD
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  2. N. Iatromanolakis MD
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  3. D. Ikkos MD
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  4. P. Gatsou BSc
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  5. C. Gardikas MD, PhD
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Kanaghinis, T., Iatromanolakis, N., Ikkos, D. et al. Intrinsic factor secretion in the gastric juice in diabetes mellitus. Digest Dis Sci 18, 85–91 (1973). https://doi.org/10.1007/BF01073150

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  • DOI: https://doi.org/10.1007/BF01073150

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