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Lymphotoxin in nonspecific inflammatory bowel disease lymphocytes

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Abstract

We have confirmed the finding that cell-free filtrates of disrupted, freshly obtained inflammatory bowel disease lymphocytes were cytotoxic in vitro for human colonic epithelial cells. Furthermore, we have shown that the properties of the cytotoxic factor in these filtrates conformed exactly to those described for lymphotoxin released by the incubation in vitro of inflammatory bowel disease lymphocytes with colonic target cells. In addition, the properties conformed very closely to those described by others in their characterization of lymphotoxin released by stimulation of lymphocytes in vitro by phytohemagglutinin except for the action of trypsin.

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Authors and Affiliations

  1. Mayo Clinic and Foundation, 55901, Rochester, Minn

    R. G. Shorter MD, FACP, K. A. Huizenga MD, R. J. Spencer MD & D. Weedon MB, BS, FRCPA

Authors
  1. R. G. Shorter MD, FACP
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  2. K. A. Huizenga MD
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  3. R. J. Spencer MD
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  4. D. Weedon MB, BS, FRCPA
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Additional information

This work was supported in part by Grant AM12808 from the National Institutes of Health, USPHS.

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Shorter, R.G., Huizenga, K.A., Spencer, R.J. et al. Lymphotoxin in nonspecific inflammatory bowel disease lymphocytes. Digest Dis Sci 18, 79–83 (1973). https://doi.org/10.1007/BF01073149

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  • DOI: https://doi.org/10.1007/BF01073149

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