Skip to main content
SpringerLink
Log in

Mannitol and glucose

Effects on gastric acid secretion and endogenous gastric inhibitory polypeptide (GIP)

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P<0.05) between 30 and 120 min and there was a significant inhibition (P<0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r=0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P<0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Day JJ, Komarov SA: Glucose and gastric secretion. Am J Dig Dis 2:527–531, 1939

    Google Scholar 

  2. Konturek S, Grossman MI: Effect of perfusion of intestinal loops with acid, fat, or dextrose on gastric secretion. Gastroenterology 49:481–489, 1965

    PubMed  Google Scholar 

  3. Shay H, Gershon-Cohen J, Fels SS, Siplet H: Concerning the influence of glucose on the response of the human stomach to test meals. Am J Dig Dis 9:363–367, 1942

    Google Scholar 

  4. Sircus W: Studies on the mechanism in the duodenum inhibiting gastric secretion. Q J Exp Physiol 43:114–133, 1958

    Google Scholar 

  5. Pederson RA, Brown JC: Inhibition of histamine, pentagastrin and insulin-stimulated canine gastric secretion by pure “gastric inhibitory polypeptide”. Gastroenterology 62:393–399, 1972

    PubMed  Google Scholar 

  6. Villar HV, Fender HR, Rayford PL, Bloom SR, Ramus NI, Thompson JC: Suppression of gastrin release and gastric secretion by gastric inhibitory polypeptide (GIP) and vasoactive intestinal polypeptide (VIP). Ann Surg 184:97–102, 1976

    PubMed  Google Scholar 

  7. Polak JM, Bloom SR, Kuzio M, Brown JC, Pearce AGE: Cellular localization of gastric inhibitory polypeptide in the duodenum and jejunum. Gut 14:284–288, 1973

    PubMed  Google Scholar 

  8. O'Dorisio TM, Cataland S, Stevenson M, Mazzaferri EL: Gastric inhibitory polypeptide (GIP): Intestinal distribution and stimulation by amino acids and medium chain triglycerides. Am J Dig Dis 16:865–872, 1976

    Google Scholar 

  9. Cataland S, Crockett SE, Brown JC, Mazzaferri EL: Gastric inhibitory polypeptide (GIP): Stimulation by oral glucose in man. J Clin Endocrinol Metab 39:223–228, 1974

    PubMed  Google Scholar 

  10. Sirinek KR, Crockett SE, Mazzaferri EL, Cataland S, Thomford NR: Release of gastric inhibitory polypeptide: Comparison of glucose and fat as stimuli. Surg Forum 25:361–363, 1974

    PubMed  Google Scholar 

  11. Brown JC, Dryburgh JR, Ross SA, Dupré J: Identification and actions of gastric inhibitory polypeptide. Rec Prog Horm Res 31:491–497, 1975

    Google Scholar 

  12. Martin EW,Jr, Sirinek KR, Spaeth JT, O'Dorisio TM, Cataland S, Thomford NR: The peak gastric acid response of the Heidenhain pouch to pentagastrin. A new concept. Rev Surg 34:293–294, 1977

    PubMed  Google Scholar 

  13. Hirschowitz BI, Sachs G: Pentagastrin in the gastric fistula dog. Gastroenterology 56:456–467, 1969

    PubMed  Google Scholar 

  14. Wheeler MH, Prescott RJ, Prescott HPM: Antral and duodenal acidification: Effect on pentagastrin-stimulated acid secretion in the dog. Am J Surg 128:331–335, 1974

    PubMed  Google Scholar 

  15. Nakajima S, Magee DF: Inhibition of Heidenhain pouch pepsin secretion by commercial cholecystokinin and duodenal fat in dogs. Ann Surg 180:243–246, 1974

    PubMed  Google Scholar 

  16. Kuzio M, Dryburgh JR, Malloy KM, Brown JC: Radioimmunoassay for gastric inhibitory polypeptide. Gastroenterology 66:357–364, 1974

    PubMed  Google Scholar 

  17. Thomas FB, Mazzaferri EL, Crockett SE, Mekhjian HS, Grumer HD, Cataland S: Stimulation of secretion of gastric inhibitory polypeptide and insulin by intraduodenal amino acid perfusion. Gastroenterology 70:523–527, 1976

    PubMed  Google Scholar 

  18. Colton T: Statistics in Medicine, 1st ed. Boston, Little, Brown, 1974

    Google Scholar 

  19. Anderson S, Nilsson G, Uvans B: Effect of acid in proximal and distal duodenal pouches on gastric secretory responses to gastrin and histamine. Acta Physiol Scand 71:368–378, 1967

    PubMed  Google Scholar 

  20. Boden G, Essa N, Owen OE, Reichle FA: Effect of intraduodenal administration of HCI and glucose on circulating immunoreactive secretin and insulin concentrations. J Clin Invest 53:1185–1193, 1974

    PubMed  Google Scholar 

  21. Svensson SO, Emås S: Effect of duodenal acidification on pentagastrin-stimulated acid secretion in Pavlov pouch cats. Scand J Gastroenterology Suppl 42, 11:55–59, 1976

    Google Scholar 

  22. Sum PT, Preshaw RM: Intraduodenal glucose infusion and pancreatic secretion in man. Lancet 2:340–341, 1967

    PubMed  Google Scholar 

  23. Unger RH, Ohneda A, Valverde I, Eisentrout AM, Exton J: Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose. J Clin Invest 47:48–65, 1968

    PubMed  Google Scholar 

  24. Hirschowitz BI, O'Leary DK: Dose dependence of insulin-stimulated gastric secretion. Am J Dig Dis 9:379–397, 1964

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, Division of Endocrinology and Metabolism, The Ohio State University, Columbus, Ohio

    Thomas M. O'Dorisio MD, James T. Spaeth MD, Edward W. Martin Jr. MD, Kenneth R. Sirinek MD, Neil R. Thomford MD, Ernest L. Mazzaferri MD & Samuel Cataland MD

  2. Department of Surgery, The Ohio State University, 410 West Tenth Avenue, 43210, Columbus, Ohio

    Thomas M. O'Dorisio MD, James T. Spaeth MD, Edward W. Martin Jr. MD, Kenneth R. Sirinek MD, Neil R. Thomford MD, Ernest L. Mazzaferri MD & Samuel Cataland MD

Authors
  1. Thomas M. O'Dorisio MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. James T. Spaeth MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Edward W. Martin Jr. MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kenneth R. Sirinek MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Neil R. Thomford MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ernest L. Mazzaferri MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Samuel Cataland MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

This study was supported in part by the Bremer Foundation 521532-7308, The National Institute of Arthritis and Metabolic Disease 5T01-AM05118-19, National Cancer Institute 5F22 CA00776-03, and the J.A. Hartford Foundation, and Clinical Associate Physician Award (RR-34).

Rights and permissions

Reprints and permissions

About this article

Cite this article

O'Dorisio, T.M., Spaeth, J.T., Martin, E.W. et al. Mannitol and glucose. Digest Dis Sci 23, 1079–1083 (1978). https://doi.org/10.1007/BF01072882

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01072882

Keywords

Search

Navigation