Abstract
The clinical significance of lactose malabsorption and the individual sensitivity to lactose were investigated in 20 patients with verified lactose malabsorption. Thirteen patients were relieved of all symptoms while seven improved only on a lactose-free diet. The healthy patients did not experience any symptoms following provocation with lactose-free milk but following provocation with increasing amounts of lactose, the tendency to diarrhea and abdominal discomfort increased considerably. Three patients experienced discomfort after provocation with only 5 g lactose. On provocation with increasing amounts of lactose the seven patients who had not recovered also developed increased abdominal discomfort but none of them developed increased tendency to diarrhea. It is concluded that, in addition to lactose malabsorption, these patients must suffer from irritable colon with tendency to constipation.
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Andersson H, Dahlqvist A, Dotevall G, Isaksson B: Dietary treatment of lactose intolerance in adults. Intestinal Enzyme Deficiencies and Their Nutritional Implications. B Borgström, A Dahlqvist, L Hambræus (eds). Stockholm, Almqvist & Wiksell, 1973, pp 81–86
Bayless TM, Rosensweig NS: A racial difference in incidence of lactase deficiency. JAMA 197:968–972, 1966
Bedine MS, Bayless TM: Intolerance of small amounts of lactose by individuals with low lactase levels. Gastroenterology 65:735–743, 1973
Bessey OA, Lowry OH, Brock MJ: A method for the rapid determination of alcaline phosphatase with five cubic millimeters of serum. J Biol Chem 164:321–329, 1946
Cook GC, Kajubi SK: Tribal incidence of lactase deficiency in Uganda. Lancet 1:725–729, 1966
Dahlqvist A: Assay of intestinal disaccharidases. Anal Biochem 22:99–107, 1968
Dunphy JV, Littman A, Hammond JB, Forstner G, Dahlqvist A, Crane RK: Intestinal lactase deficit in adults. Gastroenterology 49:12–21, 1965
Gudmand-Høyer E: Lactose malabsorption in patients operated upon for peptic ulcer. Scand J Gastroenterol 4:705–711, 1969
Gudmand-Høyer E, Thesis: Specifik lactose malabsorption in adults. Copenhagen, Århus, Ødense, FADL's forlag, 1971
Gudmand-Høyer E, Dahlqvist A, Jarnum S: The clinical significance of lactose malabsorption. Am J Gastroenterol 53:460–473, 1970
Gudmand-Høyer E, Jarnum S: The diagnosis of lactose malabsorption. Scand J Gastroenterol 3:129–139, 1968
Gudmand-Høyer E, McNair A, Jarnum S: Lactosemalabsorption i Vestgrønland. Ugeskr Læg 135:169–172, 1973
Jussila J, Launiala K, Garbatow O: Lactase deficiency on a lactose-free diet in patients with unspecific abdominal complaints. Acta Med Scand 186:217–222, 1969
Leichter J: Comparison of whole milk and skimmilk with aqueous lactose solution in lactose tolerance testing. Am J Clin Nutr 26:393–396, 1973
Littman A: Isolated lactase deficit in the adult. A present view. JAMA 195:954–955, 1966
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with Folin phenol reagent. J Biol Chem 193:265–275, 1951
Skala I, Lamacora V: Diets in lactose intolerance. Nutr Metab 13:200–206, 1971
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This investigation was supported by The Danish Medical Research Council and The Danish Hospital Foundation for Medical Research, Region of Copenhagen, Faroe Islands and Greenland.
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Gudmand-Høyer, E., Simony, K. Individual sensitivity to lactose in lactose malabsorption. Digest Dis Sci 22, 177–181 (1977). https://doi.org/10.1007/BF01072273
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DOI: https://doi.org/10.1007/BF01072273