Skip to main content
SpringerLink
Log in

Cancer in chronic ulcerative colitis

Diagnostic role of segmental colonic lavage

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Saline colonic lavage in 74 patients with chronic ulcerative colitis was performed utilizing a commercially available dental irrigating unit through a polyethylene catheter in the biopsy channel of a colonoscope or through a sigmoidoscope via a lavage-aspirating double-lumen probe. Six patients were found with colonic carcinoma. Two diagnoses of malignancy were established by cytologic smears and cell block alone. Two patients had positive mucosal biopsies and cell block. One patient with a hepatic flexure carcinoma and a second patient with a malignancy proximal to a left colon stricture were missed by these techniques. Considering the established proclivity for carcinoma in these patients, it is felt that segmental lavage in areas of stricture, grossly distorted mucosa, or endoscopically inaccessible areas represents a valuable adjunct in the diagnosis of carcinoma in chronic ulcerative colitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rosenquist H, Ohrling H, Lagercrantz R, et al: Ulcerative colitis and carcinoma coli. Lancet 1:906–908, 1959

    Google Scholar 

  2. Slaney G, Brooke BN: Cancer in ulcerative colitis. Lancet 2:694–698 1959

    Google Scholar 

  3. Edling NPG, Eklof O: Distribution of malignancy in ulcerative colitis. Gastroenterology 41:465–466, 1961

    Google Scholar 

  4. Edwards FC, Truelove SC: The course and prognosis IV: Carcinoma of the colon. Gut 5:15–22, 1964

    Google Scholar 

  5. Goldgraber MG, Kirsner JB: Carcinoma of the colon in ulcerative colitis. Cancer 17:657–665, 1964

    Google Scholar 

  6. MacDougall IPM: The cancer risk in ulcerative colitis. Lancet 2:655–658, 1964

    Google Scholar 

  7. de Dombal FT, Watts JM, Watkinson G, et al: Local complications of ulcerative colitis: Stricture, pseudo-polyposis and carcinoma of colon and rectum. Br Med J 1:1442–1445, 1966

    Google Scholar 

  8. De Vroede GJ, Taylor WF, Sauer WG, et al: Cancer risk and life expectancy of children with ulcerative colitis. N Engl J Med 285:17–21, 1971

    Google Scholar 

  9. Cook MG, Goligher JC: Carcinoma and epithelial dysplasis complicating ulcerating colitis. Gastroenterology 68:1127–1136, 1975

    Google Scholar 

  10. Truelove SC: Ulcerative colitis beginning in childhood. N Engl J Med 285:51–52, 1972

    Google Scholar 

  11. Counsell PB, Dukes CE: The association of chronic ulcerative colitis and carcinoma of the rectum and colon. Br J Surg 39:485–495, 1952

    Google Scholar 

  12. Goulston SJM, McGovern VJ: The value of rectal biopsies. Med J Aust 1:1234–1238, 1972

    Google Scholar 

  13. Hinton JM: Risk of malignant change in ulcerative colitis. Gut 7:427–432, 1966

    Google Scholar 

  14. Katz S, Sherlock P, Winawer SJ: Rectcolonic exfoliative cytology: A new approach. Am J Dig Dis 17:1109–1116, 1972

    Google Scholar 

  15. Katz S, Sherlock P, Winawer SJ: Irrigating device for gastrointestinal cytology. Gastrointest Endoscop 18:184, 1972

    Google Scholar 

  16. Katz S, Katzka I, Platt N: Exfoliative cytology in diagnosing cancer in ulcerative colitis. Gastroenterology 66:A-67/721, 1974

    Google Scholar 

  17. Morson BP, Pang LSC: Rectal biopsy as an aid to cancer control in ulcerative colitis. Gut 8:423–434, 1967

    Google Scholar 

  18. Teague RH, Read AE: Polyposis in ulcerative colitis. Gut 16:792–795, 1975

    Google Scholar 

  19. Evans DJ, Pollock DJ: In situ and invasive carcinoma of colon in patient with ulcerative colitis. Gut 13:556–571, 1972

    Google Scholar 

  20. Myrvold HE, Kock NG, Ahren CHR: Rectal biopsy and precancer in ulcerative colitis. Gut 15:301–304, 1975

    Google Scholar 

  21. Baddington MM, Truelove SC: Abnormal epithelial cells in ulcerative colitis. Br Med J 1:1318–1321, 1956

    Google Scholar 

  22. Galambos JT, Massey BW, Klayman MI, et al: Exfoliative cytology in chronic ulcerative colitis. Cancer 9:152–159, 1956

    Google Scholar 

  23. Raskin HF, Pletickat S: The cytologic diagnosis of cancer of the colon. Acta Cytol 8:131–138, 1964

    Google Scholar 

  24. Deschner EE, Long FC, Katz S: Autoradiographic method for an expanded assessment of colonic cytology. Acta Cytol 17:435–438, 1973

    Google Scholar 

  25. Fenoglio CM, Pascal RR: Adenomatous epithelium, intrapithelial anaplasia and invasive carcinoma in ulcerative colitis. Am J Dig Dis 13 556–562, 1973

    Google Scholar 

  26. Bleiberg H, Mainguet P, Galand P, et al: Cell renewal in the human rectum: In vitro autoradiography study on active ulcerative colitis. Gastroenterology 64:383–390, 1973

    Google Scholar 

  27. Eastwood GL, Trier JS: Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis. Gastroenterology 64:383–390, 1973

    Google Scholar 

  28. Xavier RG, Prolla JC, Bemvenutti GA, et al: Tissue cytogenetic studies in chronic ulcerative colitis and carcinoma of the colon. Cancer 34:684–695, 1975

    Google Scholar 

  29. Winawer SJ, Fleisher M, Melamed M, et al: Cytologic immunological (CEA) and isotope labeling studies based on gastrointestinal endoscopic lavage. Gastroenterology 66:A-146/800, 1974

    Google Scholar 

  30. Zamchek N: Carcinoembryonic antigen: Quantitative variations in circulating levels in benign and malignant digestive tract diseases. Adv Intern Med 19:413–433, 1974

    Google Scholar 

  31. Lewis B, Morson BC, Feruary AW, et al: Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change. Gut 12:1679, 1971

    Google Scholar 

  32. Filipe IM: Value of a study of the mucosubstances in rectal biopsies from patients with carcinoma of the rectum and lower sigmoid in the diagnosis of premalignant mucosa. J Clin Pathol 25:123–128, 1972

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Medicine and Pathology, Long Island Jewish-Hillside Medical Center, 1300 Union Turnpike, 11040, New Hyde Park, New York

    S. Katz MD, I. Katzka MD, N. Platt MD, E. O. Hajdu MD & E. Bassett MD

  2. Departments of Medicine and Pathology, North Shore University Hospital, Manhasset, New York

    S. Katz MD, I. Katzka MD, N. Platt MD, E. O. Hajdu MD & E. Bassett MD

  3. Departments of Medicine and Pathology, Cornell University Medical College, New York City, New York

    S. Katz MD, I. Katzka MD, N. Platt MD, E. O. Hajdu MD & E. Bassett MD

Authors
  1. S. Katz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Katzka MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. Platt MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. O. Hajdu MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Bassett MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Katz, S., Katzka, I., Platt, N. et al. Cancer in chronic ulcerative colitis. Digest Dis Sci 22, 355–364 (1977). https://doi.org/10.1007/BF01072194

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01072194

Keywords

Search

Navigation