The American Journal of Digestive Diseases

, Volume 22, Issue 4, pp 333–339 | Cite as

The association of heartburn with gastritis

  • Nicholas A. Volpicelli
  • John H. Yardley
  • Thomas R. Hendrix
Original Articles


Esophageal, fundal, antral, and duodenal mucosal biopsies from 10 patients with heartburn were compared with biopsies from 18 patients with dyspepsia but without heartburn or radiographic or endoscopic evidence of peptic, ulcer disease, gastric retention, or esophageal stricture. There was a highly significant correlation between heartburn and antral gastritis and duodenitis (P<0.01). It is suggested that histologic reflux changes are determined by the severity of reflux and reparative potential of the esophageal mucosa. Heartburn, on the other hand, is more related to the nature of the refluxed fluid. The fluid most likely to induce heartburn is one containing duodenal fluid, which is also believed to be an important cause of antral gastritis.


Public Health Gastritis Dyspepsia Esophageal Stricture Esophageal Mucosa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Digestive Disease Systems, Inc. 1977

Authors and Affiliations

  • Nicholas A. Volpicelli
    • 1
  • John H. Yardley
    • 1
  • Thomas R. Hendrix
    • 1
  1. 1.Department of Medicine and PathologyThe Johns Hopkins University School of MedicineBaltimore

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