Abstract
Because of the possibility that immunoglobulin E (IgE) is important in the pathophysiology of the human gut, we measured IgE (by radial radioimmunodiffusion) in sera of patients with various gastrointestinal diseases. IgE concentrations were normal in 71 patients with giardiasis, amebiasis, chronic ulcerative colitis, regional enteritis, chronic liver diseases, or nontropical sprue; concentrations were above the normal range in 2 of 7 patients infested with intestinal roundworms. IgE was undetectable in 2 patients with an associated deficiency of IgA and gluten-sensitive enteropathy and in 3 patients with generalized hypogammaglobulinemia, giardiasis, and malabsorption. This study of IgE in serum provides no evidence of activation of the IgE immunologic system in the disorders studied, other than in roundworm infestations. The findings contribute evidence, however, that IgE deficiency is common in immunodeficiency-related gut disorders, although the pathogenetic significance of the IgE deficit remains uncertain.
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References
Ishizaka K, Ishizaka T: Identification of γE antibodies as carrier of reaginic activity. J Immunol 99:1187–1198, 1967
Ishizaka K: Human reaginic antibodies. Ann Rev Med 21:187–200, 1970
Tada T, Ishizaka K: Distribution of γ E-forming cells in lymphoid tissues of the human and monkey. J Immunol 104:377–387, 1970
Heiner DC, Rose B: Elevated levels of γ E (IgE) in conditions other than classical allergy. J Allergy Clin Immunol 45:30–42, 1970
Johansson SGO, Mellbin T, Vahlquist B: Immunoglobulin levels in Ethiopian preschool children with special reference to high concentrations of immunoglobulin E (IgND). Lancet 1:1118–1121, 1968
Rosenberg EB, Polmar SH, Whalen GE: Increased circulating IgE in trichinosis. Ann Intern Med 75:575–578, 1971
Rosenberg EB, Whalen GE, Bennich H, Johansson SGO: Increased circulating IgE in a new parasitic disease—human intestinal capillariasis. N Engl J Med 283:1148–1149, 1970
Tomioka H, Ishizaka K: Mechanisms of passive sensitization: II. Presence of receptors of IgE on monkey mast cells. J Immunol 107:971–978, 1971
Murray M, Jarret WFH, Jennings FW: Mast cells and macromolecular leak in intestinal immunological reactions. Immunology 21:17–31, 1971
Mann JG, Brown WR, Kern F Jr: The subtle and variable clinical expression of gluten-induced enteropathy (adult celiac disease, nontropical sprue). Am J Med 48:357–366, 1970
Brown WR, Butterfield D, Savage D, Tada T: Clinical, microbiological and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders. Gut 13:441–449, 1972
Merrill D, Hartley TF, Claman HN: Electroimmunodiffusion (EID): a simple rapid method for quantitation of immunoglobulins in dilute biological fluids. J Lab Clin Med 69:151–159, 1967
Ishizaka K, Newcomb RW: Presence of γ E in nasal washings and sputum of asthmatic patients. J Allergy Clin Immunol 46:197–204, 1970
Rowe DS, Tackett L, Bennich H, Ishizaka K, Johansson SGO, Anderson SG: A research standard for human immunoglobulin E. Bull WHO 43:609–611, 1970
Kumar L, Newcomb RW, Ishizaka K, Middleton E, Hornbrook MM: IgE levels in sera of children with asthma. Pediatrics 47:848–856, 1972
Cramer H: Mathematical Methods of Statistics. Ninth edition. Princeton University Press, 1961, p 183
Remington RD, Schork MA: Statistics with Application to the Biological and Health Sciences. Englewood Cliffs, Prentice-Hall Inc, 1970, pp 313–315
Spitz E, Gelfand EW, Sheffer AL, Austen KF: Serum IgE in clinical immunology and allergy. J Allergy Clin Immunol 49:337–347, 1972
Ogawa M, Berger PA, McIntyre OR, Clendenning WE, Ishizaka K: IgE in atopic dermatitis. Arch Dermatol 103:575–580, 1971
Hogarth-Scott RS, Johansson SGO, Bennich H: Antibodies to Toxocara in the sera of visceral larva migrans patients: the significance of raised levels of IgE. Clin Exp Immunol 5:619–625, 1969
Brandborg LL, Tankersley CB, Gottlieb S, Barancik M, Sartor VE: Histological demonstration of mucosal invasion byGiardia lamblia in man. Gastroenterology 52:143–150, 1967
Waldmann TA, Polmar SH, Balestra ST, Jost MC, Bruie RM, Terry WD: Immunoglobulin E in immunologic deficiency diseases: II. Serum IgE concentrations of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wiskott-Aldrich syndrome J Immunol 109:304–310, 1972
Mietens C, Johansson SGO: Quantitative bestimmung von IgE als beitrag zur bedeutung allergischer reaktionen bei cöliakie. Monatsschr Kinderheilkd 119:332–333, 1971
Asquith P, Thompson RA, Cooke WT: Serum immunoglobulins in adult coeliac disease. Lancet 2:129–131, 1969
Hobbs JR, Hepner GW, Douglas AP, Crabbé PA, Johansson SGO: Immunological mystery of coeliac disease. Lancet 2:649–650, 1969
Jewell DP, Truelove SC: Reaginic hypersensitivity in ulcerative colitis. Gut 13:903–906, 1972
Watson DW, Bolt RJ: Immune mechanisms and ulcerative colitis. Prog Gastroenterol 1:391–411, 1968
Rider AJ, Moeller H: Hypersensitivity factors in ulcerative colitis. JAMA 183:545–546, 1963
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This work was supported by Research Funds and Training Grant in Gastroenterology TR 110 from the Denver Veterans Administration Hospital, and by the John A. Hartford Foundation, Inc.
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Brown, W.R., Lansford, C.L. & Hornbrook, M. Serum immunoglobulin E (IgE) concentrations in patients with gastrointestinal disorders. Digest Dis Sci 18, 641–645 (1973). https://doi.org/10.1007/BF01072034
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DOI: https://doi.org/10.1007/BF01072034