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The influence of prednisolone on hepatic function in normal subjects

Effects on galactose elimination capacity, sulfobromophthalein transport maximum and storage capacity, andd-glucaric acid output

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Abstract

In view of the importance of liver tests in the follow-up of patients under treatment with corticosteroid hormones, 20 mg of prednisolone were given by mouth to normal volunteers for 4 days and hepatic function was assessed before and during treatment. Despite significant falls in plasma cortisol and serum bilirubin concentrations, the galactose elimination capacity, the BSP tests, and the urinaryd-glucaric acid output remained essentially unchanged. Consequently no pharmacological effect of this corticosteroid hormone on the examined tests could be detected.

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References

  1. Peterson RE: Metabolism of adrenocorticosteroids in man. Ann NY Acad Sci 82:846–853, 1959

    Google Scholar 

  2. Sandberg AA, Slaunwhite WR: Differences in metabolism of prednisolone-C14 and cortisol-C14. J Clin Endocrin 17:1040–1050, 1957

    Google Scholar 

  3. Tygstrup N: Determination of the hepatic elimination capacity (Lm) of galactose by single injection. Scand J Clin Lab Invest 18 (Suppl 95):118–125, 1966

    Google Scholar 

  4. Imesch B, Häcki W, Bircher J: Was misst die BSP-Retention? Schweiz Med Wochenschr 103:397–403, 1973

    Google Scholar 

  5. Wheeler HO, Meltzer JI, Bradley SE: Biliary transport and hepatic storage of sulfobromophthalein sodium in the unanesthetized dog, in normal man, and in patients with hepatic disease. J Clin Invest 39:1131–1144, 1960

    Google Scholar 

  6. Preisig R, Williams R, Sweeting J, Bradley SE: Changes in sulfobromophthalein transport and storage by the liver during viral hepatitis in man. Am J Med 40:170–183, 1966

    Google Scholar 

  7. Hjelm M: A methodological study of the enzymatic determination of galactose in human whole blood, plasma and erythrocytes with galactose oxidase. Clin Chim Acta 15:87–96, 1967

    Google Scholar 

  8. Michaëlsson M, Nosslin B, Sjölin S: Plasma bilirubin determination in the newborn infant. A methodological study with special reference to the influence of hemolysis. Pediatrics 35:925–931, 1965

    Google Scholar 

  9. Clark BR, Rubin RT, Poland RE: Modification of new fluorometric method for serum and urine cortisol. Biochem Med 5:177–179, 1971

    Google Scholar 

  10. Szasz G: A kinetic photometric method for serum γ-glutamyl transpeptidase. Clin Chem 15:124–136, 1969

    Google Scholar 

  11. Richterich R: Klinische Chemie. Basel, S Karger Verlag, 1971

    Google Scholar 

  12. Marsh CA: Metabolism of D-glucuronolactone in mammalian systems. Biochem J 86:77–86, 1963

    Google Scholar 

  13. Diem K, Lentner C: Wissenschaftliche Tabellen. Documenta Geigy. Basel, JR Geigy AG, 1968

    Google Scholar 

  14. Hunter J, Maxwell JD, Carella M, Stewart DA, Williams R: Urinary D-glucaric acid excretion as a test for hepatic enzyme induction in man. Lancet 1:572–575, 1971

    Google Scholar 

  15. Williams R, Hunter J, Maxwell JD: Measurement of hepatic enzyme induction in man. Use ofd-glucaric acid excretion test. The Liver. Quantitative Aspects of Structure and Function. Basel, S Karger Verlag, 1973, pp 224–231

    Google Scholar 

  16. Gans JH, McEntee K: Comparative effects of prednisolone and thyroid hormone on bile secretion in the dog. Am J Physiol 201:577–581, 1961

    Google Scholar 

  17. Macarol V, Morris TQ, Baker KJ, Bradley SE: Hydrocortisone choleresis in the dog. J Clin Invest 49:1714–1723, 1970

    Google Scholar 

  18. Zsigmond G, Solymoss B: Effect of spironolactone, pregnenolone-16α-carbonitrile and cortisol on the metabolism and biliary excretion of sulfobromophthalein and phenol-3,6-dibromophthalein disulfonate in rats. J Pharmacol Exp Ther 183:499–507, 1972

    Google Scholar 

  19. Keiding S, Andreasen PB, Fauerholdt L: Effect of phenobarbital induction on galactose elimination capacity in the rat. Biochem Pharmacol 22:2293–2297, 1973

    Google Scholar 

  20. Simmons CJ, Davis M, Dordoni B, Williams R: Urinaryd-glucaric acid assay by an improved enzymatic procedure. Clin Chim Acta 51:47–51, 1974

    Google Scholar 

  21. Remmer H: Die Verstärkung der Abbaugeschwindigkeit von Evipan durch Glykokortikoide. Arch Exper Path Pharmakol 233:184–191, 1958

    Google Scholar 

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Authors and Affiliations

  1. Chemisches Zentrallabor, Inselspital, Berne

    A. Weiersmüller MD, J. P. Colombo MD &  J. Bircher MD

  2. Department of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH-3010, Berne, (Switzerland)

    A. Weiersmüller MD, J. P. Colombo MD &  J. Bircher MD

Authors
  1. A. Weiersmüller MD
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  2. J. P. Colombo MD
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  3. J. Bircher MD
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Supported by the Swiss National Foundation for Scientific Research.

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Weiersmüller, A., Colombo, J.P. & Bircher, J. The influence of prednisolone on hepatic function in normal subjects. Digest Dis Sci 22, 424–428 (1977). https://doi.org/10.1007/BF01071890

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  • DOI: https://doi.org/10.1007/BF01071890

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