Skip to main content
SpringerLink
Log in

Endogenous hypergastrinemia and cell proliferation in the fundic mucosa in dogs

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

Endogenous hypergastrinemia (P<0.01) was produced in 4 dogs with a Heidenhain pouch through surgical exclusion of the pyloric antrum. This was followed by acid hypersecretion and increased DNA synthesis and mitotic activity (P<0.01) in the mucosa of the Heidenhain pouch. The acid hypersecretion induced by histamine in beeswax in 4 other dogs did not increase the proliferative parameters in the pouch mucosa of the latter. A positive correlation (r=0.84,P<0.01) was found between the serum gastrin levels and the DNA synthesis index values measured in the 4 animals before antral exclusion, after antral exclusion, and after antrectomy. These data support the hypothesis that the trophic effect of gastrin on the fundic mucosa can be elicited by physiological doses of endogenous hormone.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Crean GP, Rumsey RDE, Hogg DF et al.: Experimental hyperplasia of the gastric mucosa. The Physiology of Gastric Secretion. LS Semb, J Myren (eds.) Oslo, Universitätsforlaget, 1968, pp 82–85

    Google Scholar 

  2. Crean GP, Marshall MW, Rumsey RDE: Parietal cell hyperplasia induced by the administration of pentagastrin to rats. Gastroenterology 57:147–155, 1969

    Google Scholar 

  3. Johnson LR, Aures D, Yuen L: Pentagastrin induced stimulation of protein synthesis in the gastro-intestinal tract. Am J Physiol 217:251–254, 1969

    Google Scholar 

  4. Willems G, Vansteenkiste Y, Limbosch JM: Stimulating effect of gastrin on cell proliferation kinetics in canine fundic mucosa. Gastroenterology 62:583–589, 1972

    Google Scholar 

  5. Miller LR, Jacobson ED, Johnson LR: Effect of pentagastrin on gastric mucosal cells grown in tissue culture. Gastroenterology 64:254–267, 1973

    Google Scholar 

  6. Lichtenberger L, Miller LR, Erwin DN et al.: Effect of pentagastrin on adult rat duodenal cells in culture. Gastroenterology 65:242–251, 1973

    Google Scholar 

  7. Willems G and Lehy T: Radioautographic and quantitative studies on parietal and peptic cell kinetics in the mouse. A selective effect of gastrin on parietal cell proliferation. Gastroenterology 69:416–426, 1975

    Google Scholar 

  8. Willems G, Vansteenkiste Y, Smets P: Effects of food ingestion on the cell proliferation kinetics in the canine fundic mucosa. Gastroenterology 61:323–327, 1971

    Google Scholar 

  9. Willems G, Vansteenkiste Y, Smets P: Cell proliferation in the mucosa of Heidenhain pouches after feeding in dogs. Am J Dig Dis 17:671–674, 1972

    Google Scholar 

  10. Johnson LR, Lichtenberger LM, Copeland EM, Dudrick SJ, Castro GA: Action of gastrin on gastrointestinal structure and function. Gastroenterology 68:1184–1192, 1975

    Google Scholar 

  11. Code CF, Varco RL: Prolonged action of histamine. Am J Physiol 137:225–233, 1942

    Google Scholar 

  12. Willems G, Galand P, Chretien J: Autoradiographic studies on cell population kinetics in dog gastric and rectal mucosa. A comparison between in vitro and in vivo methods. Lab Invest 23:635–639, 1970

    Google Scholar 

  13. Hunter WM, Greenwood FC: Preparation of 131-iodine labelled human growth hormone of high specific activity. Nature 194:495–496, 1962

    Google Scholar 

  14. Yalow RS, Berson SA: Size and charge distinctions between endogenous human plasma gastrin in peripheral blood and heptadecapeptide gastrins. Gastroenterology 58:609–615, 1970

    Google Scholar 

  15. Lehy T, Bonnefond A, Dubrasquet M et al.: Comparative effects of antrocolic transposition and antrectomy on fundic mucosa and acid secretion of the rat. Gastroenterology 64:421–428, 1973

    Google Scholar 

  16. Nasca S, Mignon M, Gramatica L, Accary JP, Bonfils S: Secretin effect on gastrin in dogs with chronic antral stimulation. Am J Physiol 228:1175–1181, 1975

    Google Scholar 

  17. Nilson G, Simon J, Yalow RS, Berson SA: Plasma gastrin and gastric acid responses to sham feeding and feeding in dogs. Gastroenterology 63:51–59, 1972

    Google Scholar 

  18. Lichtenberger L, Johnson LR: A possible role of gastrin in the ontogenic development of the small intestine. Am J Physiol 227:390–395, 1974

    Google Scholar 

  19. Dockray GJ, Debas HT, Walsh JT, Grossman MI: Molecular forms of gastrin in antral mucosa and serum of dogs. Proc Soc Exp Biol Med 149:550–553, 1975

    Google Scholar 

  20. Johnson LR, Guthrie P: Secretin inhibition of gastrin stimulated deoxyribonucleic acid synthesis. Gastroenterology 67:601–606, 1974

    Google Scholar 

  21. Johnson LR, Guthrie P: Effect of cholecystokinin and 16.16-Dimethylprostaglandin E2 on RNA and DNA of gastric and duodenal mucosa. Gastroenterology 70:59–65, 1976

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratories for Experimental Surgery and Laboratory of Pathology, Vrije Universiteit Brussel, Brussels, Belgium

    G. Willems MD, W. Gepts MD & A. Bremer MD

  2. Université Libre de Bruxelles, Brussels, Belgium

    G. Willems MD, W. Gepts MD & A. Bremer MD

Authors
  1. G. Willems MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Gepts MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Bremer MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Willems, G., Gepts, W. & Bremer, A. Endogenous hypergastrinemia and cell proliferation in the fundic mucosa in dogs. Digest Dis Sci 22, 419–423 (1977). https://doi.org/10.1007/BF01071889

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01071889

Keywords

Search

Navigation