The American Journal of Digestive Diseases

, Volume 21, Issue 4, pp 281–285 | Cite as

Serum bile acids in alcoholic liver disease

Comparison with histological features of the disease
  • Hyman J. Milstein
  • Joseph R. Bloomer
  • Gerald Klatskin
Original Articles


Fasting serum bile acids were measured by gas-liquid chromatography in 64 patients with alcoholic liver disease and compared with histological features in their percutaneous liver biopsy specimens. Total bile acid concentrations were normal (<2 μg/ml) or minimally increased in 6 patients in whom fatty infiltration was the only hepatic lesion. In the remaining 58 patients with more severe histological lesions, levels were increased in 93%, whereas serum bilirubins were elevated in only 43%. Chenodeoxycholic acid was usually the predomonant serum bile acid, regardless of the degree of necrosis or connective tissue change in the biopsy specimen. Only small amounts of the secondary bile acids, deoxycholic acid and lithocholic acid, were detected. Levels of these secondary bile acids did not correlate with histological features.


Bile Acid Biopsy Specimen Histological Feature Alcoholic Liver Disease Hepatic Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Digestive Disease Systems, Inc. 1976

Authors and Affiliations

  • Hyman J. Milstein
    • 1
  • Joseph R. Bloomer
    • 1
  • Gerald Klatskin
    • 1
  1. 1.Yale University School of MedicineNew Haven

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